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Clinical Trials in Canada / NCT03255408
Recruiting Phase 1/2

Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia

NCT03255408 · tracked via the Priya Life Science Canada tracker
Sponsor
University of Calgary
Phase
Phase 1/2
Started
2023-01-01
Last updated
2026-05-01

Condition(s) studied

Obstructive Sleep Apnea of AdultHypoxia, BrainSleep ApneaSleep DisorderStrokeBlood PressureEndothelial DysfunctionOxidative Stress

Investigational drug(s) / intervention(s)

Drug Lowering Cerebral Blood Flow (CBF) and Normoxia SleepDrug Lowering CBF and Intermittent Hypoxia SleepPlacebo and Normoxia SleepPlacebo and Intermittent Hypoxia Sleep

Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep: The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Normoxia Exposure

Drug Lowering CBF and Intermittent Hypoxia Sleep: The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Intermittent Hypoxia (IH) Exposure

Placebo and Normoxia Sleep: The study participants will take Placebo and sleep under Normoxia Exposure

Placebo and Intermittent Hypoxia Sleep: The study participants will take Placebo and sleep under Intermittent Hypoxia (IH) Exposure

Study summary

A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).

Eligibility

Sex
ALL
Min age
18 Years
Max age
45 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Healthy adults * 18 - 45 years of age * Living in Calgary for the past one year * Have no medical condition or should not be taking any blood pressure medications. * The participant should not be lactose intolerant Exclusion Criteria: * Cerebrovascular, cardio-respiratory, renal and metabolic diseases * Bleeding disorders and upper gastrointestinal diseases e.g. peptic ulcer disease * Pregnancy, obese and sleep-disordered breathing * Drug allergies to non-steroidal anti-inflammatories * Currently smoking

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
University of Calgary Calgary Alberta Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT03255408 on ClinicalTrials.gov ↗ ← All trials in Canada