Drug Lowering Cerebral Blood Flow (CBF) and Normoxia SleepDrug Lowering CBF and Intermittent Hypoxia SleepPlacebo and Normoxia SleepPlacebo and Intermittent Hypoxia Sleep
Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep: The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Normoxia Exposure
Drug Lowering CBF and Intermittent Hypoxia Sleep: The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Intermittent Hypoxia (IH) Exposure
Placebo and Normoxia Sleep: The study participants will take Placebo and sleep under Normoxia Exposure
Placebo and Intermittent Hypoxia Sleep: The study participants will take Placebo and sleep under Intermittent Hypoxia (IH) Exposure
Study summary
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
Eligibility
Sex
ALL
Min age
18 Years
Max age
45 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Healthy adults
* 18 - 45 years of age
* Living in Calgary for the past one year
* Have no medical condition or should not be taking any blood pressure medications.
* The participant should not be lactose intolerant
Exclusion Criteria:
* Cerebrovascular, cardio-respiratory, renal and metabolic diseases
* Bleeding disorders and upper gastrointestinal diseases e.g. peptic ulcer disease
* Pregnancy, obese and sleep-disordered breathing
* Drug allergies to non-steroidal anti-inflammatories
* Currently smoking
Primary outcome measure(s)
Changes in cerebral blood flow and ventilatory chemoreflexes — ~18 months (from the starting time of recruiting study participants) The relationship between changes in cerebral blood flow (CBF) and ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses) before and after sleeping under normoxia and intermittent hypoxia exposure among healthy human study participants.
Cerebral blood flow responses and ventilatory chemoreflexes during sleep — ~18 months (from the starting time of recruiting study participants) The relationship between cerebral blood flow (CBF) changes and ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses) during sleep under normoxia and intermittent hypoxia exposure among healthy human study participants.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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