Brain Imaging Study on Biomarkers for Chronic Back Pain

Inclusion Criteria: Chronic pain participant inclusion criteria: 1. 18-75 years of age 2. Right-handed 3. Meet the classification criteria of chronic low back pain (having low back pain for more than 6 months), as determined by a physician and documented in the participant's medical record. 4. At least 4/10 clinical pain on the Brief Pain Inventory Scale on average during the two weeks prior to enrollment 5. Comfortable completing (reading and writing) questionnaires and tasks with English language instructions Healthy participant inclusion criteria: 1. 18 - 75 years of age 2. Right-handed 3. Comfortable completing (reading and writing) questionnaires and tasks with English language instructions Exclusion Criteria: Chronic pain participant exclusion criteria: 1. History of cardiac, respiratory, or nervous system disease that may interfere with participation in the study or cause heightened potential for adverse outcome. For example: asthma or claustrophobia 2. Presence of any contraindications to MRI scanning. For example: cardiac pacemaker, metal implants, fear of closed spaces, pregnancy Healthy participant exclusion criteria: 1. Acute or chronic pain 2. History of cardiac, respiratory, or nervous system disease that, in the investigator's judgment and by asking the participant about their comfort level and ability, precludes participation in the study because of a heightened potential for adverse outcome. For example: asthma or claustrophobia 3. Presence of any contraindications to MRI scanning. For example: cardiac pacemaker, metal implants, fear of closed spaces, pregnancy