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Clinical Trials in Brazil / NCT07774845
Recruiting Observational

Platelets and Plasma Lipids Relationship as a Biomarker and Potential Therapeutic Target of Thrombogenesis

NCT07774845 · tracked via the Priya Life Science Brazil tracker
Sponsor
University of Sao Paulo
Phase
Observational
Started
2026-03-05
Last updated
2026-08-19

Condition(s) studied

Cardio Vascular Disease

Study summary

The objective of this clinical trial is to compare the effect of two different lipid emulsion formulations versus no emulsion on platelet aggregation in individuals without a history of ischemic disease. The hypothesis of this study is:

Platelet aggregation is inversely associated with higher plasma lipid concentrations.

The researchers will compare platelet aggregation in the presence and absence of lipid nanoemulsions in vitro through three pathways using the agonists collagen, adenosine diphosphate, and arachidonic acid. The tests will be performed using light-transmission aggregometry. Various participant parameters, such as lipid profile, will be evaluated to analyze possible correlations with the observed results.

Participants must:

Meet the study's inclusion criteria; Sign the informed consent form; Report to the blood draw laboratory at InCor's AB on the scheduled date and time after fasting for at least 8 hours.

Eligibility

Sex
ALL
Min age
40 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * Men and women aged ≥ 40 years. * Willingness to sign the informed consent form. * Absence of known atherosclerotic disease Exclusion Criteria: * Use of antiplatelet agents. * Use of anticoagulants. * Use of lipid-lowering agents. * Use of oral hypoglycemic agents or insulin. * Known atherosclerotic disease. * Refusal to sign the informed consent form

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Heart Institute, University of São Paulo Medical School (InCor/HCFMUSP) São Paulo São Paulo Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07774845 on ClinicalTrials.gov ↗ ← All trials in Brazil