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Clinical Trials in Brazil / NCT07663357
Recruiting Observational

Development of a Pharmacogenomic Panel for Early Detection of Chemotherapy- and Immunotherapy-Induced Cardiotoxicity.

NCT07663357 · tracked via the Priya Life Science Brazil tracker
Sponsor
Beneficência Portuguesa de São Paulo
Phase
Observational
Started
2026-05-11
Last updated
2026-06-23

Condition(s) studied

Cardiotoxicity

Study summary

To evaluate the use of a pharmacogenetic and pharmacoepigenetic panel for predicting chemotherapy- and immunotherapy-induced cardiotoxicity in cancer patients.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patients with a confirmed diagnosis of breast cancer who are scheduled to initiate treatment with anthracyclines and/or HER2-targeted therapies (anti-HER2 therapies). Exclusion Criteria: * Patients with a left ventricular ejection fraction (LVEF) \< 50%; * Patients who have undergone chemotherapy and/or radiotherapy within the previous year; * Patients with chronic kidney disease and a glomerular filtration rate (GFR) \< 30 mL/min/1.73 m²; * Patients with uncontrolled hypertension; * Patients with complex congenital heart disease.

Primary outcome measure(s)

Trial sites (6)

FacilityCityRegionStatus
Instituto do Câncer do Ceará Fortaleza Ceará Not Yet Recruiting
Complexo Hospitar HUOC/PROCAPE Recife Pernambuco Not Yet Recruiting
Universidade Federal de Santa Catarina Florianópolis Santa Catarina Not Yet Recruiting
Hospital Beneficente UNIMAR Marília São Paulo Not Yet Recruiting
FAMERP - Faculdade de Medicina de São José do Rio Preto São José do Rio Preto São Paulo Not Yet Recruiting
Hospital BP - A Beneficência Portuguesa de São Paulo São Paulo São Paulo Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07663357 on ClinicalTrials.gov ↗ ← All trials in Brazil