Evaluation of Pain Thresholds in Migraine Patients After Inhalation of Essential Oils: a Randomized Clinical Trial

NCT07493434 · tracked via the Priya Life Science Brazil tracker

Sponsor

University of Sao Paulo

Phase

Not applicable

Started

2025-03-13

Last updated

2026-03-25

Condition(s) studied

Migraine

Investigational drug(s) / intervention(s)

Lavander essential oilPeppermint essential oilLavandula angustifolia and Mentha PiperitaCoconut oil

Lavander essential oil: Lavander essential oil (Lavandula angustifolia) administered by inhalation. Six drops are applied via individual inhaler wick for inhalation during a 15- minute experimental session.

Peppermint essential oil: Peppermint essential oil (Mentha piperita) administered by inhalation. Six drops are applied via inhaler wick for inhalation during a 15-minute experimental session.

Lavandula angustifolia and Mentha Piperita: A combination of lavander (Lavandula angustifolia) and peppermint (Mentha piperita) essential oils administered by inhalation. Three drops of each administered via inhaler wick for inhalation during 15-minute experimental session.

Coconut oil: A placebo control solution consisting of coconut oil and distilled water adminstered by inhalation. Six drops of the mixture during a 15-minute experimental session.

Study summary

This study will test whether inhaling essential oils can change how sensitive people with migraine are to pressure pain. Participants will be allocated to inhale lavender, peppermint, a combination of both, or a control solution (distilled water with coconut oil). Each group will have 50 participants. The inhalation will last 15 minutes and will happen only once. Before and after the inhalation, we will measure how much pressure on certain areas of the head.

Eligibility

Sex

ALL

Min age

18 Years

Max age

60 Years

Healthy volunteers

Inclusion Criteria: * Adults aged 18-65 years * Diagnosis of episodic or chronic migraine according to the Internactional Classification of Headache Disorders (ICDH-3) * History of migraine for at least 1 year * Ability to understand and provide informed consent * Participants currently using or not using migraine preventive medication Exclusion Criteria: * Severe acute circulatory disorders * Diabetes melitus * Uncontrolled arterial hypertension * Fribromyagia * Anosmia or hyposmia * Known allergy or hypersensitivity to essential oils or their components * Pregnancy or breastfeeding

Primary outcome measure(s)

Pain pressure threshold — Baseline (pre- inhalation) and immediately after inhalation (within 15 minutes)
Pain pressure threshold mensured using a digital algometer at standardized craniofacial sites (masseter, temporalis, frontal, occipital and vertex) before and after inhalation of essential oils.

Trial sites (1)

Facility	City	Region	Status
Intitute of Psychiatry- Hospital das Clínicas, University of São Paulo	São Paulo	São Paulo

More University of Sao Paulo trials in Brazil

Performance of Next-X in Alveolar Ridge Preservation Recruiting

SBRT for Hepatocellular Carcinoma Patients With Partial Response to TACE Active, not recruiting

Evaluation of the Efficacy, Safety, and Tolerability of Lacosamide in Major Depressive Episodes of Bipolar Disorder Types I and II. Recruiting

Effects of Periodontitis on Heart Rate Variability Active, not recruiting

Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and Telangiectasias Active, not recruiting

Other trials for the same condition

Assessment of the Impact of Headache on the Employee Population of Libbs Pharmaceutical Ltd Enrolling by invitation

Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07493434 on ClinicalTrials.gov ↗ ← All trials in Brazil