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Clinical Trials in Brazil / NCT07463859
Recruiting Not applicable

Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitus

NCT07463859 · tracked via the Priya Life Science Brazil tracker
Sponsor
University of Sao Paulo
Phase
Not applicable
Started
2026-04-02
Last updated
2026-03-16

Condition(s) studied

Type 2 DiabetesHalitosisPeriodontitis

Investigational drug(s) / intervention(s)

Scaling and root planingPhotodynamic Therapy with Conventional Methylene Blue

Scaling and root planing: Mechanical removal of biofilm in periodontal pockets and tongue

Photodynamic Therapy with Conventional Methylene Blue: Antimicrobial photodynamic therapy in periodontal pockets and tongue

Study summary

The goal of this clinical trial is to evaluate the effectiveness of periodontal treatment associated with the use of a tongue scraper, compared with the same treatment combined with antimicrobial photodynamic therapy (aPDT), in reducing halitosis in individuals with periodontal disease and type 2 diabetes mellitus. The main question it aims to answer is: aPDT treatment is more effective in treating halitosis? aPDT treatment is more effective in periodontitis? Researchers will compare aPDT treatment to conventional treatment (scaling and root planning and tongue scraper) to see if aPDT has additional effects in reducing halitosis and improving periodontal health.

* Participants will be asked to visit the clinic once a week for exam and treatment during 1 month.
* After active treatment they will be asked to come to maintenance and control visits once a month until 6 months.

Eligibility

Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria: * Patients diagnosed with type 2 diabetes mellitus according to the 2019 WHO criteria * Stage 3 or 4 periodontitis * No periodontal treatment in the previous 12 months * a minimum of 20 remaining teeth. Exclusion Criteria: * Smokers * Alcohol-dependent individuals * Pregnant or lactating women * Patients with renal disorders * Patients using medications that affect the periodontium

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Bauru School of Dentistry Bauru São Paulo Recruiting

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Effects of Periodontitis on Heart Rate Variability Active, not recruiting
Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and Telangiectasias Active, not recruiting

Other trials for the same condition

iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic Diseases Recruiting
Effects of Periodontitis on Heart Rate Variability Active, not recruiting
Periodontitis Treatment and Heart Failure Active, not recruiting
A Study to Identify and Characterize Patients With Type 2 Diabetes Mellitus for Possible Participation in Ongoing or Future Type 2 Diabetes Mellitus Clinical Studies Recruiting
Assessment of Tooth Mobility After Non-surgical Periodontal Treatment Followed by Tooth Splinting Enrolling by invitation
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07463859 on ClinicalTrials.gov ↗ ← All trials in Brazil