Open Carpal Tunnel Release: All patients included in the cohort will undergo open carpal tunnel release as part of routine clinical care. The study does not assign the surgical procedure as an investigational intervention; however, it will observe clinical and ultrasonographic outcomes before and after surgery to assess prognostic factors.
Study summary
Carpal Tunnel Syndrome (CTS) is a common condition where pressure on the median nerve in the wrist causes pain, numbness, and weakness in the hand. Surgery to release the carpal tunnel is often performed to relieve these symptoms.
This study will evaluate the changes in the median nerve after surgery and how these changes relate to symptom improvement. Investigators will use ultrasound imaging to measure the nerve size before and at three and six months after surgery. Patients will also complete questionnaires about their symptoms and hand function, and undergo tests to assess strength and sensation.
The investigator's goal is to determine whether changes observed on ultrasound are associated with the rate of patient recovery. This may help doctors better monitor healing and improve care for people with CTS.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Clinical diagnosis of primary carpal tunnel syndrome (CTS), confirmed by characteristic symptoms, physical examination findings, and a cross-sectional area superior to 10 mm² in the ultrasonography baseline.
* Indication for open carpal tunnel release as part of routine clinical care.
Exclusion Criteria:
* Secondary CTS due to inflammatory arthritis, prior wrist trauma, or space-occupying lesions.
* History of previous carpal tunnel release in the affected hand.
* Concomitant peripheral neuropathies (e.g., diabetic polyneuropathy) or cervical radiculopathy
* Inability to undergo ultrasound assessment
Primary outcome measure(s)
Change in median nerve cross-sectional area (CSA) measured by high-resolution ultrasound — Baseline (preoperative) and at 3 and 6 months post-surgery The CSA of the median nerve will be assessed at two standardized locations: the carpal tunnel inlet and the carpal tunnel outlet. Measurements will be obtained using a high-frequency linear transducer (7-16 MHz) with the patient seated, forearm resting, and wrist in neutral position. The CSA will be calculated by manually tracing the inner border of the epineurium on transverse images. Assessments will be performed preoperatively and at three and six months postoperatively. The aim is to evaluate structural changes in the median nerve after carpal tunnel release and correlate them with clinical recovery.
Trial sites (1)
Facility
City
Region
Status
Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da FMUSP
São Paulo
São Paulo
Recruiting
More University of Sao Paulo General Hospital trials in Brazil
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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