Weaning Approaches for Vasopressin in Sepsis

NCT07067866 · tracked via the Priya Life Science Brazil tracker

Sponsor

Hospital Nossa Senhora da Conceicao

Phase

Phase 3

Started

2025-10-01

Last updated

2026-01-02

Condition(s) studied

Septic Shock

Investigational drug(s) / intervention(s)

Titrated weaning of vasopressin.Abrupt weaning of vasopressin.

Titrated weaning of vasopressin.: The titrated group will follow the vasopressin weaning protocol used in the DOVSS study (reduction of 0.01 U/min per hour).

Abrupt weaning of vasopressin.: The abrupt group will discontinue the vasopressin infusion at the time of randomization, without dose titration.

Study summary

In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age over 18 years * Admitted to the Intensive Care Unit * Patients with vasopressor dependent sepsis * Receiving combined norepinephrine and vasopressin therapy Exclusion Criteria: * Withdrawal/reduction of vasopressin related to a plan of treatment limitation or palliative care * Withdrawal/reduction of vasopressin associated with the initiation of adrenaline or any other vasopressor

Primary outcome measure(s)

Hypotension within the first 24 hours — 24 hours
Incidence of hypotension with clinical repercussions within the first 24 hours after titrated reduction or abrupt withdrawal of vasopressin. Definition of hypotension with clinical repercussions: mean arterial pressure \< 60 mmHg, leading to: * administration of crystalloid/colloid bolus and/or * increase in norepinephrine dose and/or * reinitiation or increase in vasopressin dose.

Trial sites (1)

Facility	City	Region	Status
Hospital Nossa Senhora da Conceição	Porto Alegre	Rio Grande do Sul	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07067866 on ClinicalTrials.gov ↗ ← All trials in Brazil