Comparative Effects Of Trichloroacetic Chemical Peel And Fractional Laser

Condition(s) studied

Investigational drug(s) / intervention(s)

35% TCA combined with croton oil peel: 3 sections every 30 days of 35% TCA combined with croton oil peel

Isolate 35% TCA peel: 3 sections every 30 days of isolate 35% TCA peel

Erbium-YAG laser: 3 sections every 30 days of Er-YAG laser

Neodymium -YAG laser Q-switched: 3 sections every 30 days of ND-YAG laser

Study summary

More than aesthetics, the search for orofacial harmonization treatments has increased when the negative emotional impact of some facial conditions such as melasma and acne scars is recognized. This study will evaluate the effects of chemical peels with 35% TCA (trichloroacetic acid) and two types of fractional laser in orofacial harmonization procedures. A sample of 100-120 participants at least 18 years of age, male or female, with complaints of melasma (n=36 to 40), acne scars (n=36 to 40) or facial wrinkles (n=36 to 40) will be recruited to underwent 3 consecutive treatment sections every 30 days. Besides clinical improvements, global satisfaction scale of the professional and the patient will be measured in addition to the impact of the treatment on the quality of life of the participants and the sensory experience in relation to pain. Pre- and pos-peeling home care will be provided to measure whether they influence results or not. The aim of this study is to identify the most appropriate treatment strategy for frequent complaints in clinical practice, and among them, the one that promotes the best experience, with the shortest recovery time and is cost-effective.

Eligibility

Primary outcome measure(s)

• Glogau scale — Baseline, 3 and 6 months
  Changes in Glogau scale (I to IV) for rejuvenation group. Higher values indicate worse aging conditions.
• Melasma index — baseline versus 3 months after treatment
  Changes in 1 to 6 scores of modified Melasma Area and Severity Index (mMASI). Higher values indicate worse melasma conditions.
• Acne Scars Index — Baseline versus 3 months after treatment
  Changes in Global 1 to 5 Scale for Acne Scar Severity (SCAR-S). Higher values indicate worse acne scars conditions.

Trial sites (2)

Other trials for the same condition