Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals

NCT07026760 · tracked via the Priya Life Science Brazil tracker

Sponsor

Universidade Federal de Pernambuco

Phase

Phase 1

Started

2022-10-01

Last updated

2025-06-18

Condition(s) studied

Healthy Individuals

Investigational drug(s) / intervention(s)

Trans-spinal magnetic stimulation (90% MT + 1 Hz)Trans-spinal magnetic stimulation (100% MT + 1 Hz)Trans-spinal magnetic stimulation (110% MT + 1 Hz)Trans-spinal magnetic stimulation (90% + 10 Hz)Trans-spinal magnetic stimulation (100% MT + 10 Hz)Trans-spinal magnetic stimulation (110% MT + 10 Hz)Trans-spinal magnetic stimulation (90% MT + 25 Hz)Trans-spinal magnetic stimulation (100% MT + 25 Hz)Trans-spinal magnetic stimulation (110% MT + 25 Hz)

Trans-spinal magnetic stimulation (90% MT + 1 Hz): Low frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

Trans-spinal magnetic stimulation (100% MT + 1 Hz): Low frequency stimulation (1 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

Trans-spinal magnetic stimulation (110% MT + 1 Hz): Low frequency stimulation (1 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

Trans-spinal magnetic stimulation (90% + 10 Hz): High frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

Trans-spinal magnetic stimulation (100% MT + 10 Hz): High frequency stimulation (10 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

Trans-spinal magnetic stimulation (110% MT + 10 Hz): High frequency stimulation (10 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

Trans-spinal magnetic stimulation (90% MT + 25 Hz): High frequency stimulation (25 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

Trans-spinal magnetic stimulation (100% MT + 25 Hz): High frequency stimulation (25 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

Trans-spinal magnetic stimulation (110% MT + 25 Hz): High frequency stimulation (25 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

Study summary

This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEP), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

Eligibility

Sex

ALL

Min age

18 Years

Max age

40 Years

Healthy volunteers

Accepted

Healthy adults aged 18-40 years, of both sexes; right-handed (confirmed via the Edinburgh Handedness Inventory); and for women, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability. Exclusion Criteria: Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions that could interfere with assessments or interventions; or use of substances that alter nervous system excitability.

Primary outcome measure(s)

Cortical excitability — Baseline (T0), immediately post-stimulation (T1), and at 15 (T2) and 30 minutes (T3) after stimulation.
Cortical excitability will be assessed using motor-evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS) over the primary motor cortex (M1), specifically targeting the cortical representation of the first dorsal interosseous (FDI) muscle. The stimulation hotspot will be defined as the scalp location that elicits the largest and most consistent MEP amplitude at the lowest stimulation intensity. Single-pulse TMS will be delivered at 100% of the resting motor threshold (RMT). Paired-pulse TMS protocols will be used to evaluate intracortical inhibition (ICI) and intracortical facilitation (ICF), using a subthreshold conditioning stimulus set at 80% of RMT and a suprathreshold test stimulus set at 120% of RMT, with interstimulus intervals of 3 ms for ICI and 10 ms for ICF. MEP amplitudes will be recorded from the FDI muscle using bipolar surface electromyography (EMG). Signals will be digitized at 20,000 Hz (bandpass 5-10,000 Hz) for offlin

Trial sites (1)

Facility	City	Region	Status
Universidade Federal de Pernambuco	Recife	Pernambuco	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07026760 on ClinicalTrials.gov ↗ ← All trials in Brazil