Splanchnic nerve neurolysis - 5 ml of absolute alcohol (100%)Celiac Plexus Neurolysis - 5 ml of absolute alcohol (100%)
Splanchnic nerve neurolysis - 5 ml of absolute alcohol (100%): Splanchnic neurolysis will be performed with 5 ml of absolute alcohol on each side at the level of the eleventh thoracic vertebra.
Celiac Plexus Neurolysis - 5 ml of absolute alcohol (100%): Celiac plexus neurolysis will be performed with 5 ml of absolute alcohol on each side at the level of the first lumbar vertebra.
Study summary
The neurolytic blocks of sympathetic chains are commonly used for the treatment of cancer-related pain. This study aims to compare celiac plexus neurolysis and splanchnic nerve neurolysis for the treatment of abdominal visceral pain and its influence on the quality of life of patients with cancer.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
Patients aged 18 years or older Presence of localized visceral pain in the upper abdomen originating from cancer of the stomach, duodenum, distal esophagus, ascending or transverse colon, liver, biliary tract, or pancreas
Ineffectiveness of analgesic treatment with third-step opioids according to the WHO analgesic ladder, including:
Opioids (≥ 60 mg/day of morphine equivalents) Antidepressants (tricyclic or dual-action), at any dosage Gabapentinoids, at any dosage Presence of side effects from analgesics that are difficult to manage with medication
Exclusion Criteria:
Presence of ascites Presence of deep vein thrombosis Presence of hepatic failure: Child-Pugh class B or C Presence of renal failure: estimated glomerular filtration rate (eGFR) \< 60 ml/min/1.73 m² Use of any anticoagulant medication
Clinical coagulation disorder, defined as:
INR \> 1.5 Prothrombin activity \< 70% or prothrombin time \> 13.5 seconds aPTT \> 40 seconds Cardiovascular failure: NYHA class III
Primary outcome measure(s)
PAIN SCORE — 1st Day Post-procedure; 15th Day Post-procedure; 30th Day Post-procedure; 2nd Month Post-procedure Pain will be assessed using the Numerical Rating Scale (NRS), a scale from 0 to 10 where: 0 indicates no pain and 10 indicates the worst possible pain.
Scores are typically categorized as:
Mild pain: 0-3 Moderate pain: 4-6 Severe pain: 7-10
Additionally, the Descriptive Verbal Scale will be used, with the following categories:
No pain Mild pain Moderate pain Severe pain.
Trial sites (1)
Facility
City
Region
Status
Instituto de Cancer Do Estado
São Paulo
São Paulo
More Instituto do Cancer do Estado de São Paulo trials in Brazil
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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