Effects of Transcranial Direct Current Stimulation Associated With Neurofunctional Rehabilitation in Individuals With Spinocerebellar Ataxias

NCT06974149 · tracked via the Priya Life Science Brazil tracker

Sponsor

Federal University of Health Science of Porto Alegre

Phase

Not applicable

Started

2025-07-07

Last updated

2026-03-16

Condition(s) studied

Ataxias Espinocerebelares

Investigational drug(s) / intervention(s)

Neurofunctional Rehabilitationtranscranial direct current stimulationNeurofunctional Rehabilitationtranscranial direct current stimulation

Neurofunctional Rehabilitation: Neurofunctional Rehabilitation Protocol will consist of balance, motor coordination and gait exercises for 40 minutes and associated with tdcs

transcranial direct current stimulation: Transcranial direct current stimulation will be applied for 20 minutes at an intensity of 2 mA. The anode will be placed on the scalp over the cerebellar area (2 cm below the inion); the cathode, in turn, will be placed on the spinal column in the lumbar enlargement (2 cm below T11)

Neurofunctional Rehabilitation: Neurofunctional Rehabilitation Protocol will consist of balance, motor coordination and gait exercises for 40 minutes and associated with tdcs

transcranial direct current stimulation: Transcranial direct current stimulation will be applied for 30 seconds at an intensity of 2 mA. The anode will be placed on the scalp over the cerebellar area (2 cm below the inion); the cathode, in turn, will be placed on the spinal column in the lumbar enlargement (2 cm below T11). However the electrodes will be kept for 20 minutes to mask the stimulation

Study summary

The aim of this study is to evaluate the effects of . Transcranial direct current stimulation (tDCS) combined with neurofunctional rehabilitation on disease severity in individuals with neurodegenerative ataxias. The study will compare whether the Neurofunctional Rehabilitation Protocol combined with real tDCS will bring better results in reducing disease severity compared to the neurofunctional rehabilitation protocol combined with simulated tDCS.

Eligibility

Sex

ALL

Min age

18 Years

Max age

90 Years

Healthy volunteers

Inclusion Criteria: * Diagnosis of spinocerebellar ataxias; * Walking independently or with aids; Exclusion Criteria: * Metal implants in the brain or spinal column and Cochlear implants; * Pregnant women

Primary outcome measure(s)

Scale for the Assessment and Rating of Ataxia (SARA) — baseline, at the end of 5 ,10 and 20 sessions and follow up ( 2 and 4 months)
The severity of ataxia will be assessed using the Ataxia Rating and Assessment (SARA) scale, which consists of eight items: gait, posture, sitting, speech, finger-chasing, nose-finger test, rapid alternation of hand movements, and lower limb coordination. The higher the score, the greater the severity of the disease.

Trial sites (1)

Facility	City	Region	Status
Neurocer	Porto Alegre	Rio Grande do Sul

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06974149 on ClinicalTrials.gov ↗ ← All trials in Brazil