Unimanual Versus Bimanual Motor Skill Learning in Acute and Chronic Stroke

Condition(s) studied

Investigational drug(s) / intervention(s)

REAplan®: motor skill learning with the REAplan® rehabilitation robot, to be performed with one or two arms

Dextrain® Manipulandum: motor skill learning with the Dextrain® Manipulandum dexterity tool to be performed with on or two hands

Study summary

To test the capacity of healthy individuals, chronic and acute stroke patients to learn and retain a complex unimanual or bimanual motor skill, trained on the neurorehabiliation robot REAplan® et the Dextrain® device. The goals are (1) to compare head-to-head bimanual versus unimanual motor learning (in the proximal and distal upper limb, UL) during the acute - early subactue stage of stroke with robotics and (2) to identify the neural substrates associated with (and deficits in) unimanual versus bimanual motor control (proximal and distal) after stroke by means of multimodal brain imaging.

Eligibility

Primary outcome measure(s)

• Unimanual/bimanual Speed/Accuracy Trade-off (SAT/bi-SAT) measured by the REAplan® robot — Change between baseline (Day 1) and after training (Day 3) and transfer from Day 3 to Day 1 on the untrained mode
  Unimanual/bimanual Speed/Accuracy Trade-off: mathematical computation of the relationship between speed and accuracy, in arbitrary units (SAT = speed (cm/s)/error (cm²).C, where C=1cm.s)
• bimanual Coordination factor (bi-CO) measured by the REAplan® robot — change between baseline (Day 1) and after training (Day 3)
  bimanual Coordination factor, mathematical measure of the phase coherence between speeds of both arms
• bi-Force, bimanual force measured by the REAplan® robot — change between baseline (Day 1) and after training (Day 3)
  bimanual forces, forces exerted in the wrong direction by each arm (Newtons)
• Root Mean Square Error (RMSE), bimanual root mean square error measured by the Dextrain® Manipulandum — change between baseline (Day 1) and after training (Day 3) and transfer between Day 3 and Day 1 on the untrained mode
  tracking error between the optimal trajectory between 2 targets and the actual trajectory
• bimanual Coordination factor (bi-CO) measured by the Dextrain(R) Manipulandum — change between baseline (Day 1) and after training (Day 3)
  bimanual Coordination factor, mathematical measure of the phase coherence between speeds of both hands
• Hold time measured by the Dextrain® Manipulandum — change between baseline (Day 1) and after training (Day 3) and transfer between Day 3 and Day 1 on the untrained mode
  The amount of time the cursor remains inside the target zone

Trial sites (1)

More University Hospital of Mont-Godinne trials in Belgium

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