Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy

Condition(s) studied

Investigational drug(s) / intervention(s)

vestibular test 1: videonystagmography

vestibular test 2: video head impulse test

vestibular evoked myogenic potentials: vestibular evoked myogenic potentials to measure the function of otolith organs

audiometry: tonal liminar audiometric thresholds

CT and MR imaging of temporal bone: Ct and MR imaging of temporal bone

p.P51S mutation: analysis of presence of p.P51S mutation in COCH

Study summary

In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well.

The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.

Eligibility

Primary outcome measure(s)

• CT and MR findings — at time of recruitment
  presence of focal sclerosis or signal loss on CT \& MR at one or more semicircular canals
• genetic test — at time of recruitment
  p.P51S mutation in COCH gene

Trial sites (1)

More Jessa Hospital trials in Belgium

Other trials for the same condition