Head and Neck CancerMultiparametric MRICervical Lymph NodeBone InvasionTumour RelapseTreatment Response
Study summary
The investigators aim to validate specific MRI parameters that could improve diagnostic accuracy of metastatic cervical lymph nodes in patients with a squamous cell carcinoma in the head and neck region. Moreover, we aim to explore specific MRI parameters that could improve diagnostic accuracy of bone invasion and tumour relapse, as well as predict treatment response and survival in this target population.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients who received a pretreatment multiparametric MRI according to a standardized protocol
* Histopathologically proven SCC in the HN region (affected group)
* Histopathologically proven Whartin tumour or pleomorphic adenoma in the HN region without malignant transformation (control group)
* Patients in whom a or multiple clearly distinguishable cervical lymph node(s) can be observed radiologically, and which can be correlated unambiguously with the pathology report
Exclusion Criteria:
* not fulfilling abovementioned criteria
* thyroid or skin cancer
* considerable artefact on MRI
* previously surgery, irradiation or chemotherapy in the HN region
Primary outcome measure(s)
discriminatory value of MRI perfusion curve between tumoural and non-tumoural cervical lymph nodes — preoperative MRI parameters will be considered validated if they enable differentiation between a metastatic cervical lymph node and a non-tumoural lymph node, as based on the final pathology report as the 'gold standard'
discriminatory value of MRI ADC value between tumoural and non-tumoural cervical lymph nodes — preoperative MRI parameters will be considered validated if they enable differentiation between a metastatic cervical lymph node and a non-tumoural lymph node, as based on the final pathology report as the 'gold standard'
discriminatory value of MRI D value between tumoural and non-tumoural cervical lymph nodes — preoperative MRI parameters will be considered validated if they enable differentiation between a metastatic cervical lymph node and a non-tumoural lymph node, as based on the final pathology report as the 'gold standard'
Trial sites (1)
Facility
City
Region
Status
Division of Maxillofacial Surgery, Department of Surgery, AZ Sint-Jan Brugge-Oostende AV
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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