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Trackers› Clinical trials› Toronto
Clinical trial register · Canada

Clinical Trials in Toronto, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Canada and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6540 matching records held by the registry are in this view. Synced 26 Sep 2026, 19:55 UTC
6540
Studies in scope
all four open statuses
3515
Recruiting now
open to new participants
887
Lead sponsors
across recruiting studies
Top sites
Toronto 137 Hamilton 10 London 10 Calgary 10 Ottawa 9
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
University Health Network, Toronto344 Sunnybrook Health Sciences Centre137 AstraZeneca117 The Hospital for Sick Children80 Centre for Addiction and Mental Health71 Clear sponsor filter
Site location
Toronto137 Hamilton10 London10 Calgary10 Ottawa9
All 25 locations
Target enrolment
to

Trials with a site in Toronto

137 of 6540 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Canada
Start
Not yet open
Ketogenic Diet and Neuromodulation in Treatment Resistant Depression
NCT07376018Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Sunnybrook Health Sciences Centre
Not applicable
60
Toronto
2026-10
Not yet open
Better Access to and Integration of Mental Health and Addiction Services Through Navigation: A Mixed-Methods Adaptive Pragmatic Clinical Trial
NCT07707492Mental Health, Addictions, Patient Navigation, Health Services
Sunnybrook Health Sciences Centre
Not applicable
480
Greater Sudbury, Toronto
2026-10
Not yet open
Eary Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT)
NCT07191145Post Traumatic Headache
DrugEptinezumab
Sunnybrook Health Sciences Centre
Phase 3
80
Toronto
2026-09-30
Not yet open
CEST for Prostate Biopsy
NCT07785024Prostate Cancer Detection
Sunnybrook Health Sciences Centre
Not applicable
20
Toronto
2026-09
Recruiting
Goal-Directed Therapy to Reduce Kidney and Cardiovascular Risk in Diabetic Kidney Disease (GOLD-STANDARD)
NCT07434791Diabetic Kidney Disease (DKD), Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease
Sunnybrook Health Sciences Centre
Not applicable
100
Toronto
2026-08-26
Not yet open
Erector Spinae Plane vs Serratus Anterior Plane Catheter Infusions for Acute Pain Management in Patients With Traumatic Rib Fractures
NCT07756047Traumatic Rib Fracture(s), Traumatic Rib Fracture
Sunnybrook Health Sciences Centre
Not applicable
66
Toronto
2026-08-01
Recruiting
Safety and Feasibility of Next-Generation Dome Helmet (NGDH) for Focused Ultrasound Neuromodulation in Substance Use Disorder (SUD)
NCT07684976Substance Use Disorder (SUD)
Sunnybrook Health Sciences Centre
Not applicable
20
Toronto
2026-07
Recruiting
InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression
NCT06781697Treatment Resistant Depression
DrugKetamine
Sunnybrook Health Sciences Centre
Phase 3
31
Toronto
2026-05-03
Not yet open
Baseline Knowledge of Stress Urinary Incontinence Among Urogynecology Patients
NCT07553884Stress Urinary Incontinence (SUI)
Sunnybrook Health Sciences Centre
Observational
90
Toronto
2026-04-30
Recruiting
Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares
NCT07245732Rheumatoid Arthritis (RA)
Sunnybrook Health Sciences Centre
Phase 4
220
Toronto
2026-04
Recruiting
A Phase II Trial Evaluating Radiation Boost to Painful Spinal Metastases
NCT07478289Spine Metastasis
Sunnybrook Health Sciences Centre
Phase 2
108
Toronto
2026-04
Not yet open
A Dose Optimization Study of Enzalutamide in Elderly Patients With Advanced Prostate Cancer
NCT07512076Prostate Cancer Patients, Elderly Patients, Pharmacokinetic Study
Sunnybrook Health Sciences Centre
Phase 2
26
Toronto
2026-04
Active, closed
Dose-dEscalated MR-Guided Radiotherapy for Localized Prostate Cancer
NCT07674225Intermediate Risk Prostate Cancer (Diagnosis), Prostate Cancer
Sunnybrook Health Sciences Centre
Not applicable
24
Toronto
2026-03-22
Not yet open
Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial
NCT07479836Cardiac Arrest
Sunnybrook Health Sciences Centre
Not applicable
1,656
Toronto
2026-03
Recruiting
Evaluation of Intercostal Neuralgia in Patients With Chest Tube Insertion After Traumatic Rib Fracture
NCT07308587Intercostal Nerve Injury
Sunnybrook Health Sciences Centre
Observational
100
Toronto
2026-01-19
Recruiting
Comparing Virtual Reality Simulation to High Fidelity Simulation as an Educational Modality for Electroconvulsive Therapy Training: A Non-Inferiority Study
NCT07350278Education, Medical, Undergraduate, Electroconvulsive Therapy, Virtual Reality Simulation
Sunnybrook Health Sciences Centre
Not applicable
78
Toronto
2026-01-18
Not yet open
Pilot Feasibility Trial of a Peer Support Program for Trauma Survivors
NCT07275892Traumatic Injury, Burns, Amputation, Mental Health Outcomes
Sunnybrook Health Sciences Centre
Not applicable
49
Toronto
2026-01-01
Not yet open
Measuring Fluid Flow in the Brain Using Alcohol and MRI in Healthy Participants
NCT04608292Diagnostic Technics, Neurological
Sunnybrook Health Sciences Centre
Not applicable
10
Toronto
2026-01
Not yet open
Study Of Ultrasound Windows For Measuring Inferior Vena Cava Changes Before Cardiac Surgery
NCT07305051Perioperative Fluid Management, Hemodynamic Monitoring, Inferior Vena Cava Collapsibility Index, Cardiac Surgery Patients
Sunnybrook Health Sciences Centre
Observational
283
Toronto
2026-01
Recruiting
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
NCT07279740Alzheimer s Disease, Alzheimer Dementia (AD), Alzheimer Dementia, Alzheimer Disease
DrugMethylphenidate
Sunnybrook Health Sciences Centre
Phase 2
12
Toronto
2026-01
Recruiting
Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study
NCT07476781Solid Tumor Malignancies, Brain Metastasases, Leptomeningeal Disease (LMD), Central Nervous System
Sunnybrook Health Sciences Centre
Not applicable
60
Toronto
2025-12-12
Recruiting
The Use of Immersive 360-degree Video in Improving Spatial Orientation
NCT05894005Virtual Reality
Sunnybrook Health Sciences Centre
Not applicable
44
Toronto
2025-11-08
Recruiting
Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma
NCT07476794Glioblastoma
Sunnybrook Health Sciences Centre
Phase 2
118
Toronto
2025-11-01
Recruiting
Levetiracetam for Persons at Risk for Alzheimer's Disease
NCT07477431Hippocampal Hyperactivation, Prodromal Alzheimer Disease
DrugLevetiracetam
Sunnybrook Health Sciences Centre
Phase 2
40
Toronto
2025-10-23
Recruiting
Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy in Symptomatic ICAD
NCT06714526Intracranial Atherosclerosis
DrugsTicagrelor·Clopidogrel·Aspirin
Sunnybrook Health Sciences Centre
Not applicable
100
Calgary, Toronto
2025-10-07
Recruiting
Analysis of Clinical Outcomes in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Tremor
NCT07212244Essential Tremor, Essential Tremor, Movement Disorders
Sunnybrook Health Sciences Centre
Observational
240
Toronto
2025-10
Recruiting
Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Treatment Refractory Obsessive Compulsive Disorder (OCD)
NCT07704632OCD, Obsessive-Compulsive Disorder (OCD), Obsessive-Compulsive Disorder
Sunnybrook Health Sciences Centre
Not applicable
20
Toronto
2025-09-23
Recruiting
Assessment of Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Disorders of Consciousness
NCT07694258Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
Sunnybrook Health Sciences Centre
Not applicable
10
Toronto
2025-09-10
Recruiting
UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4
NCT07459101Glioblastoma (GBM), Astrocytoma, Grade IV
Sunnybrook Health Sciences Centre
Not applicable
60
Toronto
2025-09-10
Recruiting
Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for Refractory Anorexia Nervosa With Comorbid Obsessive Compulsive Disorder or Major Depressive Disorder
NCT07113665Anorexia Nervosa (DSM-IV Revised Criteria)
Sunnybrook Health Sciences Centre
Phase 1
10
Toronto
2025-08
Recruiting
rTMS for Youth Inpatients With Depression
NCT07140575Major Depression Moderate, Feasibility Studies
Sunnybrook Health Sciences Centre
Not applicable
30
Toronto
2025-08
Recruiting
Using Cannabis to Treat Restless Legs Syndrome
NCT06863740Restless Leg Syndrome (RLS)
DrugCannabis oil
Sunnybrook Health Sciences Centre
Not applicable
30
Toronto
2025-07-25
Recruiting
Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases
NCT07162246Brain (Nervous System) Cancers, Brain Metastasases, SRS
Sunnybrook Health Sciences Centre
Phase 2
60
Toronto
2025-07-14
Recruiting
Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression
NCT07094789Treatment-Resistant Depression, Treatment-resistant Depression (TRD)
Sunnybrook Health Sciences Centre
Not applicable
20
Toronto
2025-07-11
Recruiting
Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression
NCT07108257Treatment-Resistant Depression, Bipolar Depression
Sunnybrook Health Sciences Centre
Not applicable
10
Toronto
2025-06-25
Recruiting
Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy
NCT07179328GBM, Glioblastoma Multiforme (GBM), Glioblastoma Multiforme of Brain, Glioblastoma Multiforme Glioma
DrugDefinity for (Perflutren Lipid Microsphere)
Sunnybrook Health Sciences Centre
Phase 1
10
Toronto
2025-06-04
Recruiting
A Randomized Neuroimaging Trial of Psilocybin in Depression
NCT06072898Depressive Disorder, Major Depressive Disorder
DrugPsilocybin
Sunnybrook Health Sciences Centre
Phase 2
50
Toronto
2025-05-28
Recruiting
Life Following Excision of Neuroendocrine Tumors
NCT06981455Neuroendocrine (NE) Tumors, Neuroendocrine Tumor GEP Grade 1-3
Sunnybrook Health Sciences Centre
Observational
246
Toronto
2025-04-28
Active, closed
Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS)
NCT07193953Amyotrophic Lateral Sclerosis, ALS
DrugDefinity for (Perflutren Lipid Microsphere)
Sunnybrook Health Sciences Centre
Phase 1
6
Toronto
2025-04-15
Recruiting
The HEROES Trial: Hyperbaric Oxygen Therapy for Endometriosis-Related Pain
NCT06579040Endometriosis-related Pain
Sunnybrook Health Sciences Centre
Not applicable
64
Toronto
2025-04-08
Recruiting
OURA Ring Wearable Testing in MDS Patients: a Feasibility and Discovery Pilot Study
NCT06270771MDS, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, RARS-T
Sunnybrook Health Sciences Centre
Observational
60
Toronto
2025-03-20
Recruiting
Topical Betamethasone Versus Moisturizer in Preventing Radiation Dermatitis in Large-Breasted Patients Treated in the Prone Position
NCT06915857Breast Cancer, Radiation Dermatitis
Sunnybrook Health Sciences Centre
Phase 3
276
Toronto
2025-02-26
Active, closed
Priming CBT With rTMS for OCD
NCT06840951Obsessive Compulsive Disorder (OCD)
Sunnybrook Health Sciences Centre
Phase 1
10
Toronto
2025-02-05
Not yet open
CPAP Randomized Controlled Trial
NCT06773416Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
Sunnybrook Health Sciences Centre
Not applicable
206
Toronto
2025-02
Recruiting
Comparing Cardiac Chamber Measurements: TTE vs. TEE Under Anesthesia
NCT06715371Heart Chambers
Sunnybrook Health Sciences Centre
Observational
114
Toronto
2025-01-27
Recruiting
Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible
NCT06055257Osteoradionecrosis, Osteoradionecrosis of Jaw, Osteoradionecrosis of the Mandible
DrugTocopherol
Sunnybrook Health Sciences Centre
Phase 3
24
Toronto
2025-01-16
Recruiting
qEEG Brain Signature of Depression & Neuromodulation-induced Recovery
NCT06719427Major Depressive Diorder
Sunnybrook Health Sciences Centre
Phase 1
100
North York, Toronto
2025-01-06
Recruiting
Deep Brain Stimulation for Refractory PTSD
NCT06705296PTSD
Sunnybrook Health Sciences Centre
Phase 1
20
Toronto
2024-11-01
Recruiting
DBS for Cognitive Deficits After Traumatic Brain Injury
NCT06818864TBI Traumatic Brain Injury
Sunnybrook Health Sciences Centre
Phase 1
10
Toronto
2024-11-01
Recruiting
Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)
NCT06423716Knee Osteoarthritis
DrugDuloxetine
Sunnybrook Health Sciences Centre
Phase 4
150
Toronto
2024-11-01
Recruiting
I-CARE: A Pilot Study of Cognitive Behavioural Therapy(CBT) for Mood and Anxiety Disorders
NCT06532500Mood Disorders, Anxiety Disorders
Sunnybrook Health Sciences Centre
Not applicable
50
Toronto
2024-10-24
Recruiting
Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Breast Cancer
NCT06185972Breast Cancer
DrugDefinity
Sunnybrook Health Sciences Centre
Phase 2
200
Toronto
2024-07-25
Recruiting
MRI-Guided Ultrasound Stimulated Microbubbles Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer
NCT06633601Breast Cancer
DrugDefinity
Sunnybrook Health Sciences Centre
Phase 1
30
Toronto
2024-07-01
Recruiting
Quantitative and Repetitive TMS in ALS - Recruiting for Stage 2
NCT05983211Amyotrophic Lateral Sclerosis
Sunnybrook Health Sciences Centre
Not applicable
15
Toronto
2024-05-01
Recruiting
Sleep Apnea and Cognition in Older Adults
NCT06423118Sleep, Cognition, Aging
Sunnybrook Health Sciences Centre
Observational
300
Toronto
2024-04-09
Not yet open
Three-Dimensional Ultrasound Imaging and Spectroscopy for Characterizing Breast Masses
NCT06175078Breast Cancer, Breast Masses
Sunnybrook Health Sciences Centre
Observational
200
Toronto
2024-04
Not yet open
Three-Dimensional Ultrasound and Spectroscopy as Early Indicators of Breast Cancer Response to Neoadjuvant Treatment
NCT06193122Breast Cancer
Sunnybrook Health Sciences Centre
Observational
200
Toronto
2024-04
Recruiting
Improving Sexual Quality of Life - Randomized Trial of Two vs Five MRI Guided SABR Treatments for Prostate Cancer
NCT05600400Prostate Cancer, Cancer of Prostate, Prostate Adenocarcinoma
Sunnybrook Health Sciences Centre
Not applicable
144
Toronto
2024-03-01
Active, closed
Efficacy Study With StrataXRT for the Prophylaxis of Radiation Dermatitis in Adjuvant Breast Radiation Treatment in Large Breasted Women Using a Prone Technique
NCT06865131Breast Cancer, Radiation Dermatitis
Sunnybrook Health Sciences Centre
Not applicable
20
Toronto
2024-02-14
Active, closed
Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments
NCT06082518Post COVID-19 Condition, Post-COVID-19 Syndrome, Post-COVID Syndrome, COVID-19
Sunnybrook Health Sciences Centre
Not applicable
40
Toronto
2024-01-02
Recruiting
Pilot Study of Dose Escalation in Prostate Radiotherapy Using the MR-Linac (DESTINATION-MRL)
NCT06177093Prostate Cancer
Sunnybrook Health Sciences Centre
Not applicable
20
Toronto
2023-12-11
Recruiting
MRI Screening for Brain Metastases Among Patients With Triple Negative or HER2+ Stage II or III Breast Cancer
NCT06247449Breast Cancer
Sunnybrook Health Sciences Centre
Not applicable
100
Toronto
2023-11-29
Recruiting
Evaluating Simplified Layered Consent for Clinical Trials
NCT06168474Staphylococcus Aureus Bacteremia
Sunnybrook Health Sciences Centre
Not applicable
346
Calgary, Hamilton, Ottawa, Toronto, Montreal, Québec
2023-11-28
Recruiting
Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study
NCT06016387HER2-positive Breast Cancer, LMD
DrugsTucatinib·Trastuzumab·Capecitabine
Sunnybrook Health Sciences Centre
Phase 2
30
Ottawa, Toronto
2023-11-25
Active, closed
Screening Using Portable Electronic Recorders for Sleep Apnea in Hypertensive At-Risk Populations (SUPER-SHARP Trial)
NCT05918120Obstructive Sleep Apnea, Hypertension
Sunnybrook Health Sciences Centre
Not applicable
190
Toronto
2023-11-13
Recruiting
UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture
NCT05865327Rib Fractures, Rib Fracture Multiple, Rib; Fracture, With Flail Chest, Pain
Sunnybrook Health Sciences Centre
Not applicable
24
Toronto
2023-10-23
Recruiting
Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents
NCT05867472Intensive Care Units, Pediatric, Anesthetics, Inhalation, Mechanically Ventilated, Critically Ill Children
DrugIsoflurane Inhalant Product
Sunnybrook Health Sciences Centre
Phase 3
60
Hamilton, London, Toronto
2023-10-10
Active, closed
Lung Ultrasound Versus Chest Radiography for Detection of Pneumothorax
NCT06022081Pneumothorax
Sunnybrook Health Sciences Centre
Not applicable
60
Toronto
2023-09-27
Recruiting
Cannabidiol Medication Intervention Trial
NCT06014424Alzheimer Disease
Sunnybrook Health Sciences Centre
Phase 2
40
Calgary, London, Toronto, Whitby
2023-09-27
Recruiting
Interleaved TMS-fMRI in Ultra-treatment Resistant Depression
NCT05813093Major Depressive Disorder
Sunnybrook Health Sciences Centre
Not applicable
88
Toronto
2023-09-27
Recruiting
MRI Guided Closed-loop TMS-EEG
NCT06050603Normal Physiology, Amnestic Mild Cognitive Impairment
Sunnybrook Health Sciences Centre
Not applicable
160
Toronto
2023-09-07
By invitation
Magnetic Stimulation as a Treatment for Female Urinary Incontinence
NCT05952258Stress Urinary Incontinence, Urgency Urinary Incontinence, Mixed Urinary Incontinence
Sunnybrook Health Sciences Centre
Not applicable
220
Toronto
2023-09-01
Recruiting
Alternative Dosing Of Niraparib To Decrease Dose Interruption In First Line Maintenance Treatment For Ovarian Cancer
NCT05961124Ovarian Cancer, Stage III Ovarian Cancer, Stage IV Ovarian Cancer, High Grade Ovarian Serous Adenocarcinoma
DrugNiraparib
Sunnybrook Health Sciences Centre
Phase 2
40
Toronto
2023-08-21
Active, closed
Simulation for Operating Room Ergonomics
NCT05541354Occupational Injuries
Sunnybrook Health Sciences Centre
Observational
28
Toronto
2023-08-18
Active, closed
A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver
NCT05677113Colorectal Cancer, Liver Metastases
Sunnybrook Health Sciences Centre
Phase 2
115
Hamilton, London, Ottawa, Toronto
2023-08-01
Recruiting
CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee
NCT05828810Revision Total Hip Arthroplasty (RTHA), Revision Total Knee Arthroplasty
Sunnybrook Health Sciences Centre
Not applicable
400
Barrie, Greater Sudbury, Toronto
2023-07-25
Active, closed
Incidence of Adductor Canal Catheter Dislodgment
NCT05961085Total Knee Arthroplasty
Sunnybrook Health Sciences Centre
Observational
100
Toronto
2023-07-10
Active, closed
UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3)
NCT05720078Glioblastoma Multiforme, Adult
Sunnybrook Health Sciences Centre
Not applicable
70
Toronto
2023-04-01
Active, closed
Oropharyngeal Exercises to Treat Obstructive Sleep Apnea
NCT05678088Obstructive Sleep Apnea
Sunnybrook Health Sciences Centre
Not applicable
45
Toronto
2023-03-28
Recruiting
The Holographic Standardized Patient
NCT05729802Medical Emergencies, Educational Problems, Simulation of Physical Illness
Sunnybrook Health Sciences Centre
Not applicable
40
Toronto
2023-03-01
Recruiting
Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy
NCT05129748Ototoxic Hearing Loss
DrugsSodium Thiosulfate·Mannitol
Sunnybrook Health Sciences Centre
Phase 2
92
Toronto
2023-02-15
Recruiting
rTMS for Apathy Clinical Trial
NCT05561205Alzheimer Disease, Apathy in Dementia, Dementia, Mild Behavioural Impairment
DrugMethylphenidate
Sunnybrook Health Sciences Centre
Not applicable
10
Toronto
2023-02-09
Active, closed
PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled Trial
NCT05466838Pancreatic Insufficiency
Sunnybrook Health Sciences Centre
Not applicable
166
Hamilton, Kingston, London, Ottawa, Toronto
2023-01-06
Active, closed
UNITy-BasED MR-Linac Adaptive Simultaneous Integrated Hypofractionated Boost Trial for High Grade Glioma in the Elderly
NCT05565521Glioblastoma Multiforme, Adult, Glioblastoma, IDH-mutant
Sunnybrook Health Sciences Centre
Phase 2
55
Toronto
2022-12-13
Active, closed
Combination of Olaparib and Navitoclax in Women with HGSC and TNBC
NCT05358639High Grade Serous Carcinoma, Triple Negative Breast Cancer, Ovarian Cancer
DrugsNavitoclax·Olaparib
Sunnybrook Health Sciences Centre
Phase 1
36
Toronto, Montreal
2022-11-09
Active, closed
A Study of StrataXRT in the Prevention of Radiation Dermatitis in Breast Cancer Patients
NCT05594498Breast Cancer, Radiation Dermatitis
Sunnybrook Health Sciences Centre
Not applicable
45
Toronto
2022-10-13
Active, closed
Effect of a Pre-operative Internet-based Educational Video on Post Operative Opioid Consumption
NCT05202080Patient Empowerment
Sunnybrook Health Sciences Centre
Not applicable
220
Toronto
2022-09-20
Recruiting
CEST in Low-grade Glioma Study
NCT05996653Low-grade Glioma
Sunnybrook Health Sciences Centre
Not applicable
100
Toronto
2022-08-12
Active, closed
The TEACH (Texting After ACS Discharge) Pilot Randomized Trial
NCT05628337Coronary Artery Disease
Sunnybrook Health Sciences Centre
Not applicable
241
Toronto
2022-06-16
Recruiting
MRI-Guided Focused Ultrasound Radiosensitization for Patients With Malignant Melanoma and Non Melanoma Skin Cancer
NCT05620290Melanoma
DrugDefinity
Sunnybrook Health Sciences Centre
Phase 1
20
Toronto
2022-06-15
Recruiting
Comparing Dual Mini-fragment Plating to Single Precontoured Plating of Acute Midshaft Clavicle Fractures Trial
NCT05231343Clavicle Fracture
Sunnybrook Health Sciences Centre
Not applicable
66
Toronto
2022-04-04
Active, closed
HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT
NCT05078034Acute Hypoxemic Respiratory Failure
Sunnybrook Health Sciences Centre
Not applicable
200
Calgary, Edmonton, Hamilton, Kingston, London, Ottawa, Toronto
2022-03-17
Recruiting
Assessment of Quality of Life and Outcomes in Patients With Primary Renal Cell Carcinoma Treated With SBRT
NCT05023265Renal Cell Carcinoma
Sunnybrook Health Sciences Centre
Not applicable
70
Toronto
2022-02-08
Recruiting
Redesigning the Surgical Pathway (PROMoTE)
NCT05114876Delirium, Cognitive Impairment, Perioperative/Postoperative Complications, Cognitive Dysfunction
Sunnybrook Health Sciences Centre
Not applicable
260
Toronto
2021-12-13
Recruiting
Using Rectal Hydrogel Spacer for Salvage SABR in Prostate Cancer
NCT05597852Prostate Cancer
Sunnybrook Health Sciences Centre
Not applicable
10
Toronto
2021-11-30
Recruiting
Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)
NCT05079464Vascular Cognitive Impairment, Mild Cognitive Impairment
Sunnybrook Health Sciences Centre
Not applicable
64
Toronto
2021-11-22
Active, closed
Mindfulness-Based Interventions for OCD
NCT04914923Obsessive-Compulsive Disorder
Sunnybrook Health Sciences Centre
Not applicable
420
Hamilton, Toronto
2021-11-09
Recruiting
Harry Potter as a Novel Educational Paradigm to Improve Mental Wellness in Children: A Prospective Trial
NCT04770168Suicidal Ideation, Suicidal and Self-injurious Behavior, Suicide Attempt
Sunnybrook Health Sciences Centre
Not applicable
3,204
Toronto
2021-09-01
Recruiting
Effect of Nasal CPAP Versus NIPPV On Diaphragm Electrical Activity (Edi) In VLBW Preterm Infants
NCT06295484Preterm Birth, Premature Lungs, Respiratory Distress Syndrome in Premature Infant
Sunnybrook Health Sciences Centre
Not applicable
24
Toronto
2021-08-21
Recruiting
Integrated Patient Avatars for Guiding Systemic Therapy Treatments in Metastatic Breast Cancer Patients
NCT04608357Breast Cancer, Breast Neoplasms, Metastatic Breast Cancer, Cancer, Breast
Sunnybrook Health Sciences Centre
Observational
25
Toronto
2021-07-21
Active, closed
Stereotactic Body Radiotherapy (SBRT) Post Prostatectomy
NCT04848909Prostate Cancer
Sunnybrook Health Sciences Centre
Not applicable
30
Toronto
2021-06-03
Active, closed
Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia
NCT04624906Waldenstrom Macroglobulinemia
DrugsAcalabrutinib·Bendamustine·Rituximab
Sunnybrook Health Sciences Centre
Phase 2
63
Calgary, Edmonton, Vancouver, Halifax, Hamilton, Ottawa, Toronto, Laval
2021-03-02
Recruiting
Nabilone for Agitation Blinded Intervention Trial
NCT04516057Alzheimer Disease, Agitation
DrugNabilone
Sunnybrook Health Sciences Centre
Phase 3
112
Calgary, London, Toronto, Whitby
2021-02-01
Active, closed
Intermittent Androgen Deprivation Therapy With or Without Stereotactic Body Radiotherapy for Molecularly Identified Hormone Sensitive Oligometastatic Prostate Cancer
NCT04619069Prostate Cancer
Sunnybrook Health Sciences Centre
Phase 1/2
60
Toronto
2020-10-27
Active, closed
Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases
NCT03775330Brain Metastases
Sunnybrook Health Sciences Centre
Observational
126
Toronto
2020-10-20
Recruiting
2 Ablative RadioTherapy Treatments for Prostate Cancer
NCT04654338Prostate Cancer
Sunnybrook Health Sciences Centre
Phase 2/3
30
Toronto
2020-07-29
Active, closed
SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival
NCT04415060Covid19, Hypoxic Respiratory Failure
DrugIsoflurane Inhalant Product
Sunnybrook Health Sciences Centre
Phase 3
800
Edmonton, London, Ottawa, Toronto, Montreal, Québec, Sherbrooke
2020-06-15
Active, closed
Randomized Phase III Trial With Mepitel Film for the Prophylaxis of Radiation Dermatitis in Breast Cancer Patients
NCT04166799Breast Cancer, Radiation Dermatitis
Sunnybrook Health Sciences Centre
Not applicable
216
Toronto
2020-01-30
Active, closed
Characterizing MyMood Patterns of Use
NCT04664374Bipolar Disorder, Mood Disorders, Depression, Dysthymia
Sunnybrook Health Sciences Centre
Observational
400
Toronto
2020-01-06
Recruiting
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
NCT04289142Delirium, Cognitive Dysfunction, Cognition Disorder, Neurocognitive Disorders
Sunnybrook Health Sciences Centre
Phase 4
2,400
Vancouver, London, Toronto, Québec, Saskatoon
2019-12-01
Active, closed
Post-Prostatectomy Linac-Based Ultrahypofractionated Radiotherapy for Patients With Localized Prostate Cancer
NCT04067570SBRT, Radical Prostatectomy
Sunnybrook Health Sciences Centre
Not applicable
30
Toronto
2019-11-07
Recruiting
ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
NCT04335994Obstructive Sleep Apnea, Alzheimer Disease, Vascular Dementia, Mild Cognitive Impairment
Sunnybrook Health Sciences Centre
Not applicable
200
Toronto
2019-09-23
Recruiting
Clonal Hematopoiesis is a Risk Factor for Chemotherapy-Related Complications
NCT04053439Lymphoma, Chemotherapeutic Toxicity
Sunnybrook Health Sciences Centre
Observational
188
Toronto
2019-08-08
Active, closed
Laser Vaginal Treatment for GSM
NCT04042766Menopausal Urethral Atrophy, Vulvar Atrophy
Sunnybrook Health Sciences Centre
Not applicable
60
Toronto
2019-08-01
Recruiting
Pilot Study to Evaluate Photoacoustic Imaging in Head and Neck Cancer
NCT04428515Head and Neck Cancer
Sunnybrook Health Sciences Centre
Observational
50
Toronto
2019-04-23
Active, closed
MRI Screening Versus SYMptom-directed Surveillance for Brain Metastases Among Patients with Triple Negative or HER2+ MBC
NCT03881605Breast Neoplasm, Brain Metastases, Triple Negative Breast Cancer, HER2-positive Breast Cancer
Sunnybrook Health Sciences Centre
Not applicable
50
Toronto
2018-11-08
Active, closed
Laser Vaginal Treatment for SUI
NCT03671694Stress Urinary Incontinence
Sunnybrook Health Sciences Centre
Not applicable
144
Toronto
2018-09-19
Active, closed
Dexmedetomidine to Reduce the Incidence of POCD After Open Cardiac Surgery
NCT03480061Delirium, Postoperative Cognitive Dysfunction, Dexmedetomidine, Cognitive Impairment
Sunnybrook Health Sciences Centre
Phase 4
90
Toronto
2018-08-09
Recruiting
PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST)
NCT03559114Traumatic Brain Injury
DrugsFragmin·Dalteparin
Sunnybrook Health Sciences Centre
Phase 3
1,100
Calgary, Edmonton, Vancouver, Halifax, Hamilton, Kingston, Ottawa, Toronto
2018-07-19
Recruiting
Superior Capsular Reconstruction vs. Partial Repair for Massive Rotator Cuff Tears
NCT03617562Rotator Cuff Tear
Sunnybrook Health Sciences Centre
Not applicable
70
Toronto
2018-07-18
Recruiting
Use of Quantitative Ultrasound to Guide Adaptive Chemotherapy Among Women With Breast Cancer
NCT04050228Breast Cancer
Sunnybrook Health Sciences Centre
Not applicable
240
Toronto
2018-06-13
Recruiting
The Sunnybrook Type 2 Diabetes Study
NCT04455867Type 2 Diabetes, PreDiabetes
Sunnybrook Health Sciences Centre
Observational
500
Toronto
2017-12-21
Recruiting
Role of Hyperpolarized 13C-Pyruvate MR Spectroscopy in Patients With Intracranial Metastasis Treated With (SRS)
NCT03324360Brain Metastases
DrugHyperpolarized 13C-Pyruvate
Sunnybrook Health Sciences Centre
Phase 1
276
Toronto
2017-12-06
Recruiting
Photoacoustic Imaging for Characterizing Breast Masses and Breast Tumor Response to Neoadjuvant Chemotherapy
NCT04428528Breast Cancer
Sunnybrook Health Sciences Centre
Observational
100
Toronto
2017-02-13
Recruiting
Stereotactic Ablative Radiation Therapy for Abiraterone-Resistant, Oligoprogressive Metastatic Prostate Cancer
NCT04838899Oligoprogressive, Castration-Resistant Prostate Cancer
Sunnybrook Health Sciences Centre
Not applicable
30
Toronto
2016-07-16
Recruiting
Metabolic Imaging of the Heart Using Hyperpolarized (13C) Pyruvate Injection
NCT02648009Hypertension, Hypertrophy
Sunnybrook Health Sciences Centre
Phase 1
112
Toronto
2016-04
Active, closed
MRI Assisted Focal Boost With HDR Monotherapy for Prostate Cancer Patients
NCT02623933Prostate Cancer
Sunnybrook Health Sciences Centre
Not applicable
60
Toronto
2015-09-24
Recruiting
Ultrasound Spectroscopy as Early Indicators of Radiation Treatment Response in Prostate, Rectum and Head & Neck Cancers
NCT03908684Prostate Cancer, Head and Neck Cancer, Rectal Cancer
Sunnybrook Health Sciences Centre
Observational
320
Toronto
2014-12-17
Active, closed
The HeLiX (Hemorrhage During Liver Resection: traneXamic Acid) Trial
NCT02261415Cancer, Tumour, Surgery
DrugTranexamic Acid
Sunnybrook Health Sciences Centre
Phase 3
1,386
Calgary, Kelowna, Halifax, Hamilton, Kingston, London, Toronto, Montreal
2014-11
Active, closed
Tomosynthesis Mammographic Imaging Screening Trial
NCT02616432Breast Cancer
Sunnybrook Health Sciences Centre
Not applicable
3,065
Vancouver, Ottawa, Toronto
2014-10
Recruiting
Investigation of Ultrasound Imaging and Spectroscopy for Characterizing Breast Masses
NCT04050423Breast Cancer
Sunnybrook Health Sciences Centre
Observational
1,200
Toronto
2014-09-23
Recruiting
Ultrasound Imaging and Spectroscopy as Early Indicators of Locally-Advanced Breast Cancer Response
NCT04134780Breast Cancer
Sunnybrook Health Sciences Centre
Observational
150
Toronto
2014-08
Active, closed
Pilot Study of Whole Gland Salvage HDR Prostate Brachytherapy for Locally Recurrent Prostate Cancer
NCT02560181Prostate Cancer Recurrent
Sunnybrook Health Sciences Centre
Not applicable
30
Toronto
2014-08
Recruiting
Hepatic Arterial Infusion Chemotherapy in Patients With Inoperable Colorectal Cancer Liver Metastasis
NCT07764497Colorectal Adenocarcinoma Metastatic in the Liver, Liver Metastasis Colon Cancer, Liver Metastases From Colorectal Cancer, Liver Metastases of Colorectal Cancer
DrugFloxuridine
Sunnybrook Health Sciences Centre
Phase 2
200
Toronto
2014-07
Active, closed
Focal Salvage HDR Brachytherapy for the Treatment of Prostate Cancer
NCT01583920Prostate Cancer
Sunnybrook Health Sciences Centre
Not applicable
60
Toronto
2012-07
Recruiting
Ultrasound Imaging, Spectroscopy and Ultrasound Imaging of Vascular Blood Flow as Early Indicators of Breast Cancer Response to Neoadjuvant Treatment.
NCT00437879Breast Cancer Invasive
Sunnybrook Health Sciences Centre
Observational
600
Toronto
2008-12-17
Active, closed
The Sunnybrook Dementia Study
NCT01800214Dementia
Sunnybrook Health Sciences Centre
Observational
1,800
Toronto
1995-09
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Canadian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 30 September 2026. https://priyalifescience.com/clinical-trials-canada/city/toronto

Query this register directly
GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Canada and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,540 studies in total at the last sync on 26 Sep 2026, 19:55 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 137 of those studies with a site in Toronto that also match the filters currently applied.

How many clinical trials are recruiting in Toronto?

84 of the 137 studies on this page are recruiting new participants as of the 26 Sep 2026, 19:55 UTC sync. A further 14 have not yet opened recruitment, 38 are active but closed to new participants, and 1 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Toronto), 137 studies
PhaseStudiesRecruitingShare
Not applicable703851.1%
Observational241517.5%
Phase 2161211.7%
Phase 11298.8%
Phase 3966.6%
Phase 4432.9%
Phase 1/2100.7%
Phase 2/3110.7%

Most active sponsors

Lead sponsors with the most studies (Toronto)
Lead sponsorStudiesRecruiting
Sunnybrook Health Sciences Centre13784
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.