Stereotactic body radiotherapy: SBRT is a non-invasive treatment approach that delivers precise and highly conformal radiotherapy to the tumour with steep dose gradients that minimize exposure to the surrounding normal tissues.
Study summary
This is a multicenter, single arm phase II study of stereotactic body radiation therapy (SBRT) for patients with medically inoperable primary renal cell carcinoma (RCC).
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients ≥18 years old
* Newly diagnosed RCC by biopsy (preferred) or radiologic evidence of growth on surveillance over two consecutive assessments (6-12 months)
* Primary lesion \>3 cm, or recurrent lesion following local ablative therapy
* Medically inoperable or patient who refuses surgery following assessment by experienced urologist, and discussed in a multidisciplinary setting
* ECOG 0-2
* Written informed consent
* Participants must be able to understand the English-language or with the aid of a translator
Exclusion Criteria:
* Primary Lesion \>20cm
* Evidence of distant metastatic disease
* Previous abdominal RT in vicinity of kidney preventing definitive SBRT
* History of major radiosensitivity syndrome
* Second invasive malignancy within the past 3 years (excluding non-melanomatous skin cancer)
* Currently pregnant or lactating
Primary outcome measure(s)
Local Control at 2 years — 2 years Local control at 2 years defined as the absence of progression of disease of the treated primary kidney cancer using Responsive Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1)
Trial sites (1)
Facility
City
Region
Status
Sunnybrook Health Sciences
Toronto
Ontario
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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