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Bayer clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine and the EU Clinical Trials Information System (CTIS) — current trials in our USA, UK, China, India, Ireland and EU (CTIS) registers with Bayer as lead sponsor. Synced 26 Sep 2026
53Current trials
24Recruiting now
24Drugs in these trials
6Trial registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov and CTIS registry records · Last verified · Editorial standards
At a glance

Bayer is the lead sponsor of 53 current clinical trials in our USA, UK, China, India, Ireland and EU (CTIS) registers. 24 are recruiting patients now. The most common phase is Observational. The drugs named most often in its trials are Darolutamide, Finerenone and Pembrolizumab. The most-studied condition is Chronic Kidney Disease.

Company profile on this site (news, sites, medicines, approvals): Bayer AG (DE) →

ClinicalTrials.gov trials by status

  • Recruiting2449%
  • Not yet open510%
  • Active, closed2041%

Trials by phase

  • Observational2041%
  • Phase 11020%
  • Phase 3816%
  • Phase 2510%
  • Phase 1/236%
  • Phase 424%
  • Not applicable12%
01

Clinical trials sponsored by Bayer

49 on ClinicalTrials.gov
StudyPhaseStatusStartRegisters
A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy
NCT06854640 · Sepsis, Coagulopathy
Phase 1 Recruiting 2025-03 USA
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
NCT05457283 · Chronic Kidney Disease, Proteinuria, Children
Phase 3 Recruiting 2022-11 UK, USA, India
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
NCT04142437 · Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion
Observational Recruiting 2020-04 Ireland, UK, USA, China
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
NCT06452277 · Advanced Non-small Cell Lung Cancer, HER2 Mutation
Phase 3 Recruiting 2024-08 UK, USA, China
First-in-human Study of 225Ac-PSMA-Trillium (BAY 3563254) in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)
NCT06217822 · Advanced Metastatic Castration-resistant Prostate Cancer, Prostate Specific Membrane Antigen (PSMA) Expression
Phase 1 Recruiting 2024-03 UK, USA
A Study to Learn More About How Safe Darolutamide is and How Well it Works Under Real World Conditions When Taken in Addition to Standard Androgen Deprivation Therapy (ADT) in Indian Participants With High-risk Non-metastatic Castration-resistant Prostate Cancer (nmCRPC)
NCT05348876 · ClinicalTrials.gov ↗ · Non-metastatic Castration-resistant Prostate Cancer
Phase 4 Recruiting 2022-08 India
A Study to Learn About How Safe BAY3389934 is and How it Affects Blood Clotting When Given Alone or With Aspirin in Healthy Participants
NCT07652723 · Drug-drug Interaction
Phase 1 Recruiting 2026-05 USA
A Phase I Study of BAY3498264 Given Together With Sotorasib in Participants Who Have Advanced Solid Cancers With Specific Genetic Changes Called KRASG12C Mutation
NCT06659341 · Advanced Solid Tumors Harboring KRAS G12C Mutation
Phase 1 Recruiting 2024-11 UK
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
NCT06760819 · ClinicalTrials.gov ↗ · Advanced Solid Tumors, HER2 Mutation
Phase 2 Recruiting 2025-02 USA, China
A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine
NCT06772025 · Cardiac Surgery-associated Acute Kidney Injury
Not applicable Recruiting 2025-02 UK
A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation
NCT07535112 · Advanced/Metastatic Colorectal Adenocarcinoma
Drug: Cetuximab
Phase 1 Recruiting 2026-04 USA
A Study to Learn How Well a Combination of Darolutamide and Androgen Deprivation Therapy (ADT) Works as a Treatment Before Surgery for Men Who Have High-risk Localized Prostate Cancer.
NCT07450599 · ClinicalTrials.gov ↗ · High-risk Localized Prostate Cancer
Phase 2 Recruiting 2026-04 China
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
NCT07192952 · ClinicalTrials.gov ↗ · Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)
Phase 3 Recruiting 2026-06 UK, USA
An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a Paediatric Dosing Device is Used in Preterm Babies With Retinopathy of Prematurity in the United Kingdom (UK)
NCT06315556 · ClinicalTrials.gov ↗ · Retinopathy of Prematurity, Preterm Infants
Observational Recruiting 2024-03 UK
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
NCT07188805 · ClinicalTrials.gov ↗ · Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)
Phase 3 Recruiting 2025-11 UK, USA
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors
NCT06914128 · ClinicalTrials.gov ↗ · MTAP-deleted Solid Tumors
Phase 1/2 Recruiting 2025-03 UK, USA, China
A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer
NCT06764316 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma
Phase 1 Recruiting 2025-02 UK, USA, China
A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation
NCT07625215 · ClinicalTrials.gov ↗ · Atrial Fibrillation
Phase 2 Recruiting 2026-08 USA
A Study to Learn About Heart-Related Risks in Elderly Men With Advanced Prostate Cancer Treated With Enzalutamide or Darolutamide
NCT07672119 · ClinicalTrials.gov ↗ · Prostate Cancer
Observational Recruiting 2026-06 USA
A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications
NCT07330258 · ClinicalTrials.gov ↗ · Parkinson's Disease
Observational Recruiting 2026-07 USA
First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)
NCT05099172 · ClinicalTrials.gov ↗ · Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation
Phase 1/2 Recruiting 2021-10 USA, China
A Study to Learn About Real-world Utilization and Outcomes of Darolutamide and Other Androgen Receptor Pathway Inhibitors (ARPIs) for Newly Diagnosed Metastatic Hormone-sensitive Prostate Cancer (de Novo mHSPC) in US Urology Clinics
NCT07406282 · ClinicalTrials.gov ↗ · Prostatic Neoplasms, Metastatic Hormone-Sensitive Prostate Cancer
Observational Recruiting 2025-07 USA
An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
NCT06278207 · ClinicalTrials.gov ↗ · Chronic Kidney Disease, Type 2 Diabetes Mellitus
Observational Recruiting 2024-05 USA
An Observational Study Conducted in China to Evaluate the Efficacy and Safety of Darolutamide in Combination With Androgen Deprivation Therapy (ADT) for Men With Non-metastatic Prostate Cancer That Progressed Following Prior Bicalutamide + ADT Treatment
NCT07538843 · ClinicalTrials.gov ↗ · Non-metastatic Castration-resistant Prostate Cancer
Observational Recruiting 2026-07 China
Post Approval Observational Study to Learn More About How Safe Octocog Alfa is and How Well it Works in Patients With Severe Hemophilia A in India
NCT07446010 · Hemophilia A
Observational Not yet open 2026-09 India
A Study of Darolutamide Plus Androgen Deprivation Therapy in Patients With Metastatic Hormone-sensitive Prostate Cancer in India
NCT07806591 · ClinicalTrials.gov ↗ · Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Observational Not yet open 2026-10 India
An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health
NCT05477953 · ClinicalTrials.gov ↗ · Chagas Disease
Observational Not yet open 2026-12 USA
Phase 1 Study in Healthy Adults to See How Sevabertinib Changes Metformin Levels in the Body
NCT07753252 · ClinicalTrials.gov ↗ · Healthy Participants
Phase 1 Not yet open 2026-08 USA
An Observational Study to Learn How Mirena and Other Progestogen Treatments Are Used for Endometrial Protection in Women 40+ With a Uterus in the United States Receiving Estrogen Therapy, and Their Respective Health Outcomes
NCT07795606 · ClinicalTrials.gov ↗ · Estrogen Therapy
Observational Not yet open 2026-08 USA
A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children
NCT02637687 · Solid Tumors Harboring NTRK Fusion
Phase 1/2 Active, closed 2015-12 Ireland, UK, USA, China
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria
NCT05196035 · ClinicalTrials.gov ↗ · Chronic Kidney Disease, Proteinuria
Phase 3 Active, closed 2022-03 UK, USA, India
The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema
NCT06075147 · Visual Impairment, Neovascular Age-related Macular Degeneration (nAMD), Diabetic Macula Edema (DME)
Observational Active, closed 2024-02 UK
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
NCT05587296 · ClinicalTrials.gov ↗ · Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes
Phase 3 Active, closed 2022-10 Ireland, UK
An Observational Study to Learn More About How Safe Finerenone is and How Well it Works in Indian People With Chronic Kidney Disease and Type 2 Diabetes in Routine Medical Practice
NCT06763146 · ClinicalTrials.gov ↗ · Chronic Kidney Disease, Type 2 Diabetes Mellitus
Observational Active, closed 2025-09 India
A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors
NCT05537740 · ClinicalTrials.gov ↗ · Advanced Solid Tumors
Phase 1 Active, closed 2022-10 UK, USA, China
A Study to Learn About How Well BAY 3401016 Works in Adults With Alport Syndrome
NCT07211685 · ClinicalTrials.gov ↗ · Alport Syndrome
Phase 2 Active, closed 2025-11 UK, USA, India, China
An Observational Study to Learn More About How Safe Vericiguat is and How Well it Works in Indian People With Chronic Heart Failure With Reduced Ejection Fraction and Worsening Chronic Heart Failure Under Real World Conditions
NCT06632483 · ClinicalTrials.gov ↗ · Chronic Heart Failure With Reduced Ejection Fraction, Worsening Chronic Heart Failure
Observational Active, closed 2025-09 India
A First-in-human Study to Learn How Safe the Study Drug BAY2965501 is, Find the Best Dose (Single Drug & Combination), How it Affects the Body, What Maximum Amount Can be Given, How it Moves Into, Through and Out of the Body, How it Acts on Different Tumors in Participants With Advanced Solid Tumors
NCT05614102 · ClinicalTrials.gov ↗ · Advanced Solid Tumors
Phase 1 Active, closed 2022-11 UK, USA, China
A Study to Learn How Men With Advanced Prostate Cancer Respond to Treatment With Darolutamide and Hormone Therapy, With or Without Chemotherapy, in Real-world Medical Practice
NCT07344779 · ClinicalTrials.gov ↗ · Metastatic Hormone-Sensitive Prostate Cancer
Observational Active, closed 2026-01 UK
RADIANT: A Study of Radium-223 Dichloride (Xofigo) vs Enzalutamide or Abiraterone (ARPIs, Androgen Receptor Pathway Inhibitors) in Patients With Prostate Cancer That Has Spread to the Bones (mCRPC, Metastatic Castration-Resistant Prostate Cancer)
NCT04597125 · ClinicalTrials.gov ↗ · Metastatic Castrate Resistant Prostate Cancer (mCRPC)
Phase 4 Active, closed 2020-11 UK
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
NCT04464226 · ClinicalTrials.gov ↗ · Cancer
Phase 3 Active, closed 2020-10 UK, USA, China
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
NCT05794906 · ClinicalTrials.gov ↗ · Biochemically Recurrent Prostate Cancer
Phase 3 Active, closed 2023-04 UK, USA, China
A Study to Learn How Safe the Study Treatment Actinium-225-macropa-pelgifatamab (BAY3546828) is, How it Affects the Body, How it Moves Into, Through and Out of the Body, and About Its Anticancer Activity in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)
NCT06052306 · ClinicalTrials.gov ↗ · Metastatic Castration-resistant Prostate Cancer
Phase 1 Active, closed 2023-09 UK
An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery
NCT06117891 · ClinicalTrials.gov ↗ · Unresectable Hepatocellular Carcinoma
Observational Active, closed 2023-11 USA, China
An Observational Study in the United States to Learn How Venous Thromboembolism, Disseminated Intravascular Coagulation, and Sepsis Are Related
NCT06765681 · ClinicalTrials.gov ↗ · Sepsis, Venous Thromboembolism, Disseminated Intravascular Coagulation
Observational Active, closed 2025-01 USA
A Study Called FINE-REAL to Learn More About the Use of the Drug Finerenone in a Routine Medical Care Setting
NCT05348733 · ClinicalTrials.gov ↗ · Chronic Kidney Disease, Type 2 Diabetes Mellitus
Observational Active, closed 2022-06 USA, China
A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described
NCT04122976 · ClinicalTrials.gov ↗ · Prostate Cancer
Observational Active, closed 2020-01 USA, China
Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A
NCT03932201 · ClinicalTrials.gov ↗ · Hemophilia A
Observational Active, closed 2019-10 USA
A Study of Continued Treatment With Regorafenib in Participants With Solid Tumors Who Have Participated in Other Bayer Studies
NCT06246643 · ClinicalTrials.gov ↗ · Solid Malignant Tumors
Phase 2 Active, closed 2024-01 China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

02

Bayer in the EU trials register (CTIS)

4 trials

Authorised or ongoing trials in the EU Clinical Trials Information System with Bayer as sponsor. Some are the same study as a ClinicalTrials.gov record above; the two registries share no common ID. Trials with a site in Ireland are listed first.

StudyPhaseStatusCountries
[22961] A placebo-controlled, parallel-group, double blind, randomized, multi-cohort Phase 2 study to investigate efficacy, safety, tolerability, pharmacodynamics and pharmacokinetics of BAY 3670549 in adult participants with atrial fibrillation.
2025-523807-31-00 · Cardiovascular Diseases
Phase 2 Ongoing Belgium, Netherlands, Germany + 4 more
(22597) A study to learn about how safe nitroglycerin is and how it affects the body when taken along with nurandociguat in people with coronary artery disease.
2025-522335-34-00 · CTIS ↗ · Cardiovascular Diseases
Phase 1 Authorised Germany, Bulgaria
(21467) A Phase 3, single-arm, open-label extension study to evaluate the safety of finerenone in addition to standard of care, in pediatric heart failure patients, from birth to 18 years of age, with left ventricular systolic dysfunction (LVSD)
2024-519830-22-00 · CTIS ↗ · Cardiovascular Diseases
Phase 3 Ongoing Czechia, Germany, Greece + 10 more
A study to learn how safe nurandociguat is when taken with sildenafil in men with arterial hypertension.
2025-522336-14-00 · CTIS ↗ · Cardiovascular Diseases
Phase 1 Authorised Germany
03

Drugs in Bayer trials

24 compounds

Drugs and biologicals named as interventions in these trials, with the number of this sponsor's trials that name each one. Placebos and generic comparators are excluded.

04

Conditions in Bayer trials

53 conditions
Chronic Kidney Disease5Advanced Solid Tumors3Type 2 Diabetes Mellitus3Proteinuria2Left Ventricular Systolic Dysfunction2Heart Failure (Pediatric)2Metastatic Hormone-Sensitive Prostate Cancer2Sepsis2Prostate Cancer2HER2 Mutation2Hemophilia A2Non-metastatic Castration-resistant Prostate Cancer2Solid Tumors Harboring NTRK Fusion1Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion1Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer1Hot Flashes1Advanced Non-small Cell Lung Cancer, HER2 Mutation1Children1Advanced Metastatic Castration-resistant Prostate Cancer1Prostate Specific Membrane Antigen (PSMA) Expression1Visual Impairment1Neovascular Age-related Macular Degeneration (nAMD)1Diabetic Macula Edema (DME)1Advanced Solid Tumors Harboring KRAS G12C Mutation1
05

By trial register

RegisterTrialsRecruiting
Clinical trials in USA3318
Clinical trials in UK2311
Clinical trials in China188
Clinical trials in India82
Clinical trials in Ireland31
EU register (CTIS)4—

A trial with sites in more than one country appears in each of those registers.

06

Other sponsors in Chronic Kidney Disease

SponsorTrials
Shandong Suncadia Medicine2
Shenzhen Salubris Pharmaceuticals2
Prokidney1
Yuanjun Yang1

Sponsors with the most current trials registered for this condition.

07

Questions about Bayer trials

How many clinical trials does Bayer sponsor?

Bayer is the lead sponsor of 49 current trials on ClinicalTrials.gov in our USA, UK, China, India and Ireland registers, and 4 authorised or ongoing trials in the EU register (CTIS), as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Bayer trials recruiting?

Yes. 24 of its 49 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Which drugs is Bayer testing?

Its current trials name 24 drugs and biologicals as interventions. The most frequent are Darolutamide (8), Finerenone (7), Pembrolizumab (3), Aflibercept (2) and BAY3389934 (2). The number in brackets is how many of its trials name each drug.

Does Bayer have clinical trials in Ireland?

Yes. 3 trials in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

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How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.