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Compound · clinical trials

HRS-4642 clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 12 trials in our China register that name HRS-4642 as an intervention. Synced 25 Sep 2026
12Current trials
9Recruiting now
6Lead sponsors
1Country register
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

HRS-4642 is named as an intervention in 12 current clinical trials in our China register. 9 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Jiangsu HengRui Medicine Co., Ltd (3). The most-studied condition is Pancreatic Cancer.

Trials by status

  • Recruiting975%
  • Not yet open18%
  • Active, closed217%

Trials by phase

  • Phase 2758%
  • Phase 1/2433%
  • Phase 118%
01

Clinical trials of HRS-4642

12 trials
StudyPhaseStatusLead sponsorRegisters
Exploratory Platform Research on Precision Therapy of Advanced Pancreatic Cancer
NCT06547736 · ClinicalTrials.gov ↗ · Pancreatic Cancer
Phase 2 Recruiting Fudan University China
HRS-4642 in Combination With AG for Neoadjuvant and Adjuvant Treatment of Pancreatic Cancer
NCT06587061 · ClinicalTrials.gov ↗ · Pancreatic Cancer
Phase 2 Recruiting Ruijin Hospital China
A Study of HRS-4642 Monotherapy or in Combination With Adebrelimab in the Treatment of Advanced Biliary Tract Tumors.
NCT06620848 · ClinicalTrials.gov ↗ · Biliary Tract Cancer
Phase 2 Recruiting Shanghai Zhongshan Hospital China
HRS-4642 With Nimotuzumab and Chemotherapy for First-line Treatment of Advanced Pancreatic Cancer Patients
NCT06770452 · Metastatic Pancreatic Carcinoma
Phase 2 Recruiting Zhejiang University China
An Exploratory Clinical Study of HRS-4642 in Combination With Immunotherapy and Chemotherapy for Pancreatic Cancer
NCT06938282 · ClinicalTrials.gov ↗ · Pancreatic Cancer
Phase 2 Recruiting Shanghai Zhongshan Hospital China
HRS-4642 in Combination With Gemcitabine and Albumin-bound Paclitaxel and Adebrelimab for Neoadjuvant and Adjuvant Treatment of Pancreatic Cancer
NCT07131514 · ClinicalTrials.gov ↗ · Pancreatic Cancer
Phase 2 Recruiting Ruijin Hospital China
HRS-4642 in Combination With Nimotuzumab and Chemotherapy for BRPC With KRAS G12D Mutation
NCT07240766 · ClinicalTrials.gov ↗ · Borderline Resectable Pancreatic Adenocarcinoma
Phase 2 Recruiting Zhejiang University China
Exploratory Clinical Study of HRS-4642 Combined With Adebrelimab in the Treatment of Advanced Pancreatic Ductal Adenocarcinoma
NCT06427239 · ClinicalTrials.gov ↗ · Pancreatic Cancer
Phase 1/2 Recruiting Fudan University China
HRS-4642 Combination With Other Antitumor Therapies in Patients With Solid Tumors
NCT07296341 · ClinicalTrials.gov ↗ · Locally Advanced or Metastatic Pancreatic Cancer With
Phase 1/2 Recruiting Shanghai Hengrui Pharmaceutical Co., Ltd. China
An Open-Label, Multicenter, Phase IB/II Clinical Study of HRS-7172 in Combination With Antitumor Therapy in Participants With Solid Tumors
NCT07806058 · ClinicalTrials.gov ↗ · Pancreatic Cancer
Phase 1/2 Not yet open Jiangsu HengRui Medicine Co., Ltd. China
A Study of HRS-4642 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation
NCT06385678 · ClinicalTrials.gov ↗ · Advanced KRAS G12D Mutant Solid Tumors
Phase 1/2 Active, closed Jiangsu HengRui Medicine Co., Ltd. China
Phase I Study of HRS-4642 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation
NCT05533463 · ClinicalTrials.gov ↗ · Advanced KRAS G12D Mutant Solid Tumors
Phase 1 Active, closed Jiangsu HengRui Medicine Co., Ltd. China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with HRS-4642

6 conditions
Pancreatic Cancer6Advanced KRAS G12D Mutant Solid Tumors2Metastatic Pancreatic Carcinoma1Biliary Tract Cancer1Borderline Resectable Pancreatic Adenocarcinoma1Locally Advanced or Metastatic Pancreatic Cancer With1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Jiangsu HengRui Medicine Co., Ltd.3
Zhejiang University2
Shanghai Zhongshan Hospital2
Fudan University2
Ruijin Hospital2
Shanghai Hengrui Pharmaceutical Co., Ltd.1
04

By country register

RegisterTrialsRecruiting
Clinical trials in China129

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about HRS-4642 trials

How many clinical trials are testing HRS-4642?

12 current trials in our China register name HRS-4642 as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are HRS-4642 trials recruiting patients?

Yes. 9 of the 12 trials are recruiting: 9 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors HRS-4642 clinical trials?

Jiangsu HengRui Medicine Co., Ltd (3), Zhejiang University (2), Shanghai Zhongshan Hospital (2) and Fudan University (2), among 6 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how HRS-4642 works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how HRS-4642 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists HRS-4642 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.