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Trackers› Clinical trials› USA
Clinical trial register · United States · industry-sponsored

Industry-sponsored studies with a US investigative site

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9110 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 22 Sep 2026, 03:16 UTC
9110
Studies in scope
industry-sponsored, all four open statuses
4947
Recruiting now
open to new participants
2198
Lead sponsors
across recruiting studies
Top states
California 5292 Florida 4393 Illinois 2478 Georgia 2343 Arizona 2230
Narrow the register
Recruitment status
Phase
Lead sponsor
AstraZeneca299 Novartis Pharmaceuticals202 Eli Lilly and Company190 Merck Sharp & Dohme LLC183 AbbVie172
State
California5292 Florida4393 Illinois2478 Georgia2343 Arizona2230
All 51 states
Target enrolment
to
9110 of 9110 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Recruiting
ASSURE WCD Clinical Evaluation - Post Approval Study (ACE-PAS)
NCT05135403Sudden Cardiac Arrest
Kestra Medical Technologies, Inc.
Observational
5,179
Washington
2021-11-20
Active, closed
Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas
NCT04924608Neurofibromatosis 1, Plexiform Neurofibroma (PN)
AstraZeneca
Phase 3
145
Florida, Maryland, Missouri, New York
2021-11-19
Active, closed
A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer
NCT05091567Small-Cell Lung Cancer
Hoffmann-La Roche
Phase 3
660
Georgia, Illinois, Maine, Massachusetts, Michigan, New York, Ohio, Rhode Island
2021-11-18
Active, closed
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)
NCT05130450Familial Chylomicronemia Syndrome
Ionis Pharmaceuticals, Inc.
Phase 3
60
California, Florida, Illinois, Kansas, New York, Pennsylvania
2021-11-18
Active, closed
Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis
NCT05134441Multiple Sclerosis
Immunic AG
Phase 3
1,121
Arizona, California, Florida, Illinois
2021-11-18
Recruiting
CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
NCT05143996Relapsed/Refractory Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
Cullinan Therapeutics Inc.
Phase 1
60
Alabama, California, Florida, Georgia, Massachusetts, New York, North Carolina, Ohio
2021-11-18
Active, closed
Safety, Tolerability, and Immunogenicity of MenABCWY Administered on Different Dosing Schedules in Healthy Adolescents
NCT05087056Meningitis, Meningococcal
GlaxoSmithKline
Phase 2
312
Arizona, California, Georgia, Indiana, Montana, North Carolina
2021-11-18
Recruiting
Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitors
NCT05145127Hemophilia A, Hemophilia B
Pfizer
Phase 3
245
Iowa, New York, Pennsylvania, Washington
2021-11-17
Active, closed
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
NCT04958265Atypical Hemolytic Uremic Syndrome
Hoffmann-La Roche
Phase 3
41
Colorado, Nebraska, New Jersey
2021-11-17
Recruiting
First in Human Study of TORL-1-23 in Participants With Advanced Cancer
NCT05103683Advanced Solid Tumor, Ovarian Cancer, Endometrial Cancer, NSCLC
TORL Biotherapeutics, LLC
Phase 1
90
California, Kentucky, Minnesota, New York, Ohio, Texas, Virginia
2021-11-17
Active, closed
Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT05089734Non-Small Cell Lung Cancer
Gilead Sciences
Phase 3
603
Alaska, Arizona, California, Colorado, Florida, Illinois, Iowa, Kansas
2021-11-17
Recruiting
Knee Related Subchondral Bone Lesions Treated With IOBP
NCT05314608Subchondral Cyst
Arthrex, Inc.
Observational
100
Colorado, Florida, Maryland, Ohio, Pennsylvania
2021-11-17
Active, closed
A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
NCT04812925Primary Immune Thrombocytopenia
argenx
Phase 3
173
Arkansas, District of Columbia, Indiana, Iowa, Oklahoma
2021-11-17
Active, closed
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
NCT04988295Carcinoma, Non-Small-Cell Lung
Janssen Research & Development, LLC
Phase 3
776
Alabama, Arizona, California, Colorado, Florida, Georgia, Mississippi, Nebraska
2021-11-17
Active, closed
A Study of Lu AF82422 in Participants With Multiple System Atrophy
NCT05104476Multiple System Atrophy
H. Lundbeck A/S
Phase 2
64
California, Colorado, Florida, Illinois, Massachusetts, Minnesota, Nebraska, New York
2021-11-16
Active, closed
Clinical Trial of MED HF10™ Spinal Cord Stimulation for the Treatment of Chronic Pain
NCT06897280Chronic, Intractable Back Pain and/or Leg Pain
Nevro Corp
Phase 4
25
Kansas
2021-11-16
Active, closed
A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders
NCT05112861Age-Related Macular Degeneration, Neovascular Age-related Macular Degeneration, Wet Macular Degeneration, BRVO - Branch Retinal Vein Occlusion
Outlook Therapeutics, Inc.
Phase 3
120
Illinois, Maryland, Pennsylvania
2021-11-15
Active, closed
Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Previously Treated Patients With Metastatic, Radio-active Iodine Refractory BRAF V600E Mutation Positive Differentiated Thyroid Cancer
NCT04940052Differentiated Thyroid Cancer (DTC)
Novartis Pharmaceuticals
Phase 3
153
Illinois, Massachusetts
2021-11-15
Active, closed
Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures
NCT04851717Pediatric ALL
Acacia Pharma Ltd
Phase 2/3
100
California, Massachusetts, Minnesota, Pennsylvania, Texas
2021-11-15
Recruiting
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
NCT04819841Sickle Cell Disease
Kamau Therapeutics
Phase 1/2
15
California, Missouri, New York, Ohio
2021-11-15
Active, closed
A Study of TAK-007 in Adults With Relapsed or Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)
NCT05020015Relapsed or Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)
Takeda
Phase 2
27
Alabama, California, District of Columbia, Florida, Georgia, Illinois, Michigan, New York
2021-11-12
Active, closed
Efficacy and Safety of Frexalimab (SAR441344) in the Treatment of Systemic Lupus Erythematosus
NCT05039840Systemic Lupus Erythematosus
Sanofi
Phase 2
109
Alabama, Arizona, California, Florida, New Mexico, New York, Oklahoma, Tennessee
2021-11-10
Recruiting
Ceribell Delirium Data Collection Study
NCT04962815Delirium
Ceribell Inc.
Observational
200
California, Florida, Iowa, Missouri, New Jersey, North Carolina, Pennsylvania
2021-11-10
Recruiting
A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
NCT05130437Propionic Acidemia
ModernaTX, Inc.
Phase 1/2
50
California, Michigan, New York, North Carolina, Pennsylvania, Texas
2021-11-09
Recruiting
(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
NCT04996875Advanced Systemic Mastocytosis (AdvSM), SM With an Associated Hematologic Neoplasm (SM-AHN), Mast Cell Leukemia (MCL), Aggressive Systemic Mastocytosis (ASM)
Cogent Biosciences, Inc.
Phase 2
140
Alabama, Arizona, California, Florida, Georgia, Illinois, Massachusetts, New York
2021-11-09
Recruiting
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
NCT05065216Acute Stroke, Ischemic Stroke, Stroke
DiaMedica Therapeutics Inc
Phase 2/3
728
Alabama, California, Florida, Georgia, Illinois, Kansas, Louisiana, Massachusetts
2021-11-07
Active, closed
A Study of NDI 1150-101 in Patients With Solid Tumors
NCT05128487Solid Tumor, Renal Cell Carcinoma (Kidney Cancer), Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma, Non-Small Cell Lung Cancer
Nimbus Saturn, Inc.
Phase 1/2
106
Arizona, Connecticut, District of Columbia, Florida, Kentucky, Maryland, Michigan, Minnesota
2021-11-05
Active, closed
Open-Label Study of 18F-mFBG for Imaging Myocardial Sympathetic Innervation
NCT04535193Cardiovascular Diseases
Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)
Phase 1/2
10
New York
2021-11-05
Active, closed
A Study of the Safety and Tolerability in Participants With PIK3CA-related Overgrowth Spectrum or Proteus Syndrome Who Are Being Treated With Miransertib (MK-7075) in Other Studies (MK-7075-006)
NCT04980872PIK3CA-Related Overgrowth Spectrum (PROS)/Proteus Syndrome (PS)
Merck Sharp & Dohme LLC
Phase 2
60
Georgia, Massachusetts, Ohio, Texas, Washington
2021-11-02
Active, closed
Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression
NCT05163041Advanced Solid Tumor
BicycleTx Limited
Phase 1/2
200
Iowa, New York, Ohio, Pennsylvania, Texas, Virginia
2021-11-02
Active, closed
Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia
NCT04994717Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL)
Amgen
Phase 3
303
California, Florida, Ohio, South Carolina, Texas
2021-11-02
Active, closed
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
NCT05121844Weight Loss, Metabolic Syndrome, Pre-diabetes, Central Obesity
Signos Inc
Not applicable
31,187
California
2021-11-02
Active, closed
Prospective Decision Impact Clinical Utility Trial of KidneyIntelX
NCT05198284Diabetic Kidney Disease, Chronic Kidney Diseases, Chronic Kidney Disease Stage 1, Chronic Kidney Disease Stage 2
Renalytix AI, Inc.
Observational
2,000
New York
2021-11-01
Recruiting
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
NCT05005403Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Micro Satellite Stable Colorectal Cancer, Gastric/Esophageal Cancer
AbbVie
Phase 1
694
California, Illinois, Indiana, Kentucky, Michigan, Minnesota, Nebraska, North Carolina
2021-11-01
Active, closed
Electrical Muscle Stimulation with 1064 Nm Diode Laser and RF/PEMF for Non-invasive Body Contouring and Fat Reduction.
NCT05256771Fat Reduction, Muscle Tone Increased
Venus Concept
Not applicable
36
California, New Jersey, Tennessee
2021-11-01
Active, closed
Cinrebafusp Alfa in Combination With Ramucirumab and Paclitaxel in HER2-High Gastric or GEJ Adenocarcinoma and in Combination With Tucatinib in HER2-Low Gastric or GEJ Andenocarinoma
NCT05190445HER2-positive Gastric Cancer
Pieris Pharmaceuticals, Inc.
Phase 2
80
California, Maryland, New York, Texas
2021-11-01
Active, closed
Desara ® One Single Incision Sling 522 Study
NCT04772131Stress Urinary Incontinence
Caldera Medical, Inc.
Not applicable
300
Arizona, Florida, Idaho, Indiana, Kentucky, Massachusetts, Missouri, Nevada
2021-11-01
Active, closed
Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy
NCT05112237Cardiomyopathy
Tenaya Therapeutics
Observational
200
Arkansas, California, Colorado, Delaware, Florida, Missouri, New York, Ohio
2021-11-01
Active, closed
Decision Impact Trial of KidneyIntelX
NCT04791358Diabetic Kidney Disease
Renalytix AI, Inc.
Observational
1,500
New York
2021-11-01
Active, closed
Cone Beam Breast CT for Breast Cancer Screening
NCT05036096Breast Cancer
Koning Corporation
Not applicable
1,024
Florida, Georgia, Tennessee
2021-10-30
Active, closed
A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors
NCT05117476Advanced Solid Tumor, NSCLC
Cullinan Therapeutics Inc.
Phase 1
440
Alabama, California, Florida, Massachusetts, Michigan, New Jersey, New York, North Carolina
2021-10-29
Active, closed
AlloSure Lung Assessment and Metagenomics Outcomes Study
NCT05050955Lung Transplant Infection, Lung Transplant; Complications, Lung Transplant Failure and Rejection
CareDx
Observational
550
Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Maryland
2021-10-29
Recruiting
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
NCT04981119Solid Tumor, Adult, Colorectal Cancer, Non Small Cell Lung Cancer, Pancreatic Cancer
A2 Biotherapeutics Inc.
Observational
500
Arizona, California, Florida, Massachusetts, Minnesota, Missouri, New York, Ohio
2021-10-29
Recruiting
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT
NCT04862468Thrombosis, Deep Vein, Iliofemoral; Thrombosis
Mercator MedSystems, Inc.
Phase 2
80
California, Connecticut, Florida, Georgia, Louisiana, Maryland, New Jersey, New York
2021-10-29
Active, closed
A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations
NCT05048797Locally Advanced or Metastatic Non-Small Cell Lung Cancer
AstraZeneca
Phase 3
454
Alaska, California, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania
2021-10-28
Active, closed
Savolitinib Plus Durvalumab Versus Sunitinib and Durvalumab Monotherapy in MET-Driven, Unresectable and Locally Advanced or Metastatic PRCC
NCT05043090Papillary Renal Cell Carcinoma
AstraZeneca
Phase 3
148
Massachusetts, New York
2021-10-28
Active, closed
A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma
NCT04712097Relapsed or Refractory Follicular Lymphoma
Hoffmann-La Roche
Phase 3
478
California, Georgia, Indiana, Maryland, Michigan, Missouri, New York, North Carolina
2021-10-27
Active, closed
Pyrocarbon Clinical Follow-up Study
NCT05049993Osteoarthritis of the Shoulder, Avascular Necrosis, Traumatic Arthritis
Stryker Trauma and Extremities
Observational
76
Colorado, Florida, Louisiana, Maryland, Minnesota, Missouri, North Carolina, Oregon
2021-10-27
Active, closed
Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants
NCT04988386Amyloid Cardiomyopathy, Transthyretin-Related
Eidos Therapeutics, a BridgeBio company
Phase 3
389
California, Colorado, Illinois, Maryland, Massachusetts, Minnesota, Missouri, New York
2021-10-27
Recruiting
Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-cell Lymphoma
NCT04989803Relapsed and/or Refractory B-cell Lymphoma
Kite, A Gilead Company
Phase 1/2
247
Arizona, California, Florida, Georgia, Illinois, Kentucky, Maryland, Minnesota
2021-10-27
Active, closed
ARX788 in HER2-positive, Metastatic Breast Cancer Subjects (ACE-Breast-03)
NCT04829604HER2 Positive Metastatic Breast Cancer
Ambrx, Inc.
Phase 2
72
California, Georgia, Illinois, Kentucky, Maryland, Massachusetts, Missouri, Nebraska
2021-10-26
Active, closed
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus
NCT04963296Systemic Lupus Erythematosus
Hoffmann-La Roche
Phase 3
303
Alabama, Arkansas, California, Florida, Michigan, New York, North Carolina, Ohio
2021-10-26
Recruiting
Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis
NCT04833894Generalized Myasthenia Gravis
argenx
Phase 2/3
12
Illinois, North Carolina, Virginia
2021-10-26
Recruiting
First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)
NCT05099172Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation
Bayer
Phase 1/2
400
Arizona, California, Georgia, Maryland, Massachusetts, Michigan, New York, Tennessee
2021-10-25
Active, closed
Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors
NCT04337177Solid Tumors, Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma
Valent Technologies, LLC
Phase 1
20
Arizona, California, District of Columbia, Georgia, Indiana, Missouri, North Carolina, Ohio
2021-10-25
Active, closed
Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
NCT05113251Breast Neoplasms, Breast Cancer, HER2-positive Early Breast Cancer
AstraZeneca
Phase 3
927
Arkansas, California, Connecticut, Indiana, Kentucky, Louisiana, Minnesota, Nevada
2021-10-25
Active, closed
Harmony TPV Post-Approval Study
NCT05077774Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
Medtronic Cardiovascular
Not applicable
174
Alabama, California, Colorado, Florida, Illinois, Massachusetts, Michigan, Missouri
2021-10-25
By invitation
Long-term Safety Extension Study of OLZ/SAM in Pediatric Subjects
NCT04987229Bipolar I Disorder, Schizophrenia
Alkermes, Inc.
Phase 3
236
Alabama, Arkansas, California, District of Columbia, Florida, Georgia, Illinois, Indiana
2021-10-22
Recruiting
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
NCT04929223Metastatic Colorectal Cancer
Hoffmann-La Roche
Phase 1
542
Alabama, Arizona, California, Colorado, Connecticut, Florida, Illinois, Louisiana
2021-10-22
Active, closed
A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET
NCT05050942Gastro-enteropancreatic Neuroendocrine Tumor
Camurus AB
Phase 3
332
Arizona, California, Colorado, Florida, Kentucky, Louisiana, Massachusetts, Minnesota
2021-10-22
Active, closed
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
NCT04861259Atypical Hemolytic Uremic Syndrome
Hoffmann-La Roche
Phase 3
83
California, Colorado, Georgia, Missouri, Ohio, Texas
2021-10-22
Active, closed
A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors
NCT04857372Mesothelioma
Novartis Pharmaceuticals
Phase 1
137
California, Illinois, Massachusetts, Ohio, Texas
2021-10-21
Recruiting
Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease
NCT05045482Hepatic Impairment, Cirrhosis, Cholestatic Liver Disease
Zydus Therapeutics Inc.
Phase 1
30
Indiana
2021-10-21
Active, closed
Osteosarcoma Maintenance Therapy With OST31-164
NCT04974008Bone Cancer
Emerald Clinical Inc.
Phase 2
39
California, Colorado, Connecticut, Delaware, Florida, Georgia, Illinois, Maryland
2021-10-21
Active, closed
Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)
NCT05082454Aortic Valve Disease
JOTEC GmbH
Observational
108
Pennsylvania, Texas, Virginia
2021-10-20
Active, closed
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
NCT05198674Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
Medtronic Vascular
Not applicable
1,899
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2021-10-20
Recruiting
ConsideRAte Study - Splenic Stimulation for RA
NCT05003310Rheumatoid Arthritis
Galvani Bioelectronics
Not applicable
28
Alabama, California, Maryland, New York, Oregon, Pennsylvania, Texas
2021-10-19
By invitation
Multi-Center Clinical Database of Infants for the Investigation of Early Nutrition Biomarkers
NCT05049655Infant Development
ByHeart
Observational
2,000
Alabama, Arizona, Arkansas, Idaho, Ohio, South Carolina, Tennessee, Utah
2021-10-19
Active, closed
Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain
NCT04809376Osteoarthritis, Knee
Paradigm Biopharmaceuticals USA (INC)
Phase 2/3
602
Arizona, California, Florida, Illinois, Kansas, Louisiana, Nevada, South Carolina
2021-10-19
Active, closed
A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer
NCT04958239Neoplasms
Boehringer Ingelheim
Phase 1
151
Arizona, California, North Carolina, South Dakota, Texas
2021-10-18
Recruiting
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
NCT05123482Breast Cancer, Biliary Tract Carcinoma, Ovarian Cancer, Endometrial Cancer
AstraZeneca
Phase 1/2
460
California, Louisiana, Maryland, Massachusetts, Missouri, New Mexico, New York, North Carolina
2021-10-18
Active, closed
A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)
NCT05104866Breast Cancer
AstraZeneca
Phase 3
732
California, Florida, Georgia, Massachusetts, Michigan, New York, Ohio, Oregon
2021-10-18
Active, closed
A Long-term Extension Study of Ustekinumab in Pediatric Participants
NCT05092269Crohn Disease, Colitis, Ulcerative, Arthritis, Psoriatic
Janssen Research & Development, LLC
Phase 3
159
Georgia, New York, North Carolina, Virginia
2021-10-18
By invitation
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs
NCT04930289Interstitial Lung Disease, COPD, Cystic Fibrosis, Pulmonary Fibrosis
Paragonix Technologies
Observational
3,500
Arizona, California, Florida, Maryland, Massachusetts, New York, North Carolina, Pennsylvania
2021-10-15
Active, closed
A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma
NCT05083169Multiple Myeloma
Janssen Research & Development, LLC
Phase 3
587
Alabama, California, Connecticut, Georgia, Massachusetts, Michigan, Ohio, Pennsylvania
2021-10-14
Recruiting
US National OCS Liver Perfusion (OLP) Registry
NCT05940857Liver Transplant
TransMedics
Observational
100,000
Alabama, Arizona, California, Florida, Georgia, Kentucky, Massachusetts, Michigan
2021-10-14
Active, closed
OCS Liver Perfusion (OLP) Post-Approval Registry
NCT05074160Liver Transplant
TransMedics
Observational
166
Alabama, California, Georgia, Massachusetts, Michigan, Nebraska, North Carolina, Texas
2021-10-14
Active, closed
Study of Vimseltinib for Tenosynovial Giant Cell Tumor
NCT05059262Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor, Diffuse
Deciphera Pharmaceuticals, LLC
Phase 3
123
California, Colorado, Kansas, Massachusetts, Minnesota, New York, North Carolina, Ohio
2021-10-14
Active, closed
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
NCT05029882Non-Small Cell Lung Cancer, Advanced Solid Tumors, Gastroesophageal Adenocarcinoma, Colorectal Cancer
AbbVie
Phase 1
520
California, Colorado, Connecticut, Illinois, Indiana, Louisiana, Michigan, New York
2021-10-13
By invitation
SPI-1005 Treatment in Moderate COVID-19 Patients
NCT04484025Covid19, Corona Virus Infection, Coronavirus, Coronavirus Infection
Sound Pharmaceuticals, Incorporated
Phase 2
60
Connecticut, Idaho, Kansas, Missouri, North Carolina, Texas
2021-10-12
Recruiting
PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR
NCT04889872Aortic Stenosis, Calcific, Aortic Valve Stenosis
Edwards Lifesciences
Not applicable
2,250
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Idaho
2021-10-12
Active, closed
A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
NCT04895696Systemic Lupus Erythematosus
Beeline Medicines Corporation
Phase 2
248
Alabama, California, Florida, Georgia, Illinois, Kentucky, Louisiana, Maryland
2021-10-11
Recruiting
STRIVE Post-Market Registry Study
NCT04302272Emphysema
Olympus Corporation of the Americas
Observational
150
Arizona, California, Florida, Illinois, Louisiana, Maryland, Massachusetts, Mississippi
2021-10-09
Active, closed
A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
NCT04931342Ovarian Cancer
Hoffmann-La Roche
Phase 2
176
California, Missouri, North Carolina, Ohio, Oklahoma, Texas, Virginia, Washington
2021-10-07
Active, closed
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP
NCT04971226Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive
Novartis Pharmaceuticals
Phase 3
405
Colorado, Florida, Kentucky, Massachusetts, North Carolina, Oregon, South Dakota, Tennessee
2021-10-06
Active, closed
Study Evaluating the Safety and Efficacy of Islatravir in Combination With Lenacapavir in Virologically Suppressed People With HIV
NCT05052996HIV-1 Infection
Gilead Sciences
Phase 2
142
California, Colorado, District of Columbia, Florida, Georgia, Hawaii, Illinois, Indiana
2021-10-05
Active, closed
Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis
NCT04926818Multiple Sclerosis (MS)
Novartis Pharmaceuticals
Phase 3
129
Arkansas, California, District of Columbia, Florida, Pennsylvania, Wisconsin
2021-10-05
Recruiting
A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
NCT05020236Multiple Myeloma
Pfizer
Phase 3
893
California, Colorado, Florida, Louisiana, New Jersey, New York
2021-10-04
Active, closed
A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer
NCT04975308Breast Neoplasms, Neoplasm Metastasis
Eli Lilly and Company
Phase 3
874
Arizona, California, Colorado, Florida, Hawaii, Illinois, Indiana, Kentucky
2021-10-04
Recruiting
PSMA-PET to Guide Prostatectomy
NCT05381103Prostate Cancer
Five Eleven Pharma, Inc.
Phase 2/3
288
Indiana
2021-10-01
Active, closed
Prospera Test Evaluation in Cardiac Transplant (ProTECT)
NCT05205551Heart Transplant Rejection
Natera, Inc.
Observational
411
California
2021-10-01
Active, closed
BOLT-DVT: Study of the Indigo® Aspiration System When Used in Patients With Deep Vein Thrombosis
NCT05003843Deep Vein Thrombosis, DVT
Penumbra Inc.
Not applicable
229
California, Delaware, District of Columbia, Florida, Illinois, Indiana, Kentucky, Louisiana
2021-09-30
Recruiting
A Study of NX-1607 in Adults With Advanced Malignancies
NCT05107674Ovarian Cancer, Epithelial, Gastric Cancer, GastroEsophageal Junction (GEJ) Cancer, Head and Neck Squamous Cell Carcinoma
Nurix Therapeutics, Inc.
Phase 1
345
California, Colorado, Illinois, North Carolina, Oklahoma, Texas, Virginia, Washington
2021-09-29
Active, closed
Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing
NCT05059522Advanced Malignancies, NSCLC, Ovarian Cancer, Urothelial Cancer
Pfizer
Phase 3
77
Arkansas, California, Florida, New Jersey, New York, Pennsylvania, Texas, Washington
2021-09-29
Recruiting
Open-label Study of WVE-N531 in Patients With Duchenne Muscular Dystrophy (FORWARD-53)
NCT04906460Duchenne Muscular Dystrophy
Wave Life Sciences USA, Inc.
Phase 1/2
26
Arkansas, Georgia
2021-09-28
Active, closed
A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer
NCT04931654Carcinoma, Non-Small-Cell Lung, Gastric Cancer, Gastroesophageal Junction Cancer
AstraZeneca
Phase 1/2
136
Georgia, Indiana, New York, Tennessee
2021-09-28
Recruiting
First in Human, Dose Escalation Study of AN4005
NCT04999384Advanced Solid Tumor, Advanced Lymphoma
Adlai Nortye Biopharma Co., Ltd.
Phase 1
31
New Jersey, New York, South Carolina, Virginia
2021-09-27
Active, closed
Avenir Complete Post-Market Clinical Follow-Up Study
NCT04731077Osteoarthritis, Hip, Avascular Necrosis of Hip, Avascular Necrosis of the Femoral Head, Post-traumatic; Arthrosis
Zimmer Biomet
Not applicable
275
Mississippi, Missouri, Oregon
2021-09-27
Active, closed
SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer
NCT04977024COVID-19 Infection, Hematopoietic and Lymphoid System Neoplasm, Leukemia, Lymphoma
GeoVax, Inc.
Phase 2
63
California, Maryland, Massachusetts, New York, North Carolina, Washington
2021-09-27
Active, closed
A Phase 1/2/3 Study of UX701 Gene Therapy in Adults With Wilson Disease
NCT04884815Wilson Disease
Ultragenyx Pharmaceutical Inc
Phase 1/2
82
California, Illinois, Indiana, Massachusetts, Michigan, North Carolina, Ohio, Tennessee
2021-09-27
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Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site. Derived from ClinicalTrials.gov. Retrieved 22 September 2026. https://priyalifescience.com/clinical-trials-usa?page=75

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Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.