Symptom Distribution and Pain Sensitization in Carpal Tunnel Syndrome

Condition(s) studied

Investigational drug(s) / intervention(s)

Nerve ultrasound: Ultrasonographic evaluation of the median nerve at the carpal tunnel and adjacent levels

Nerve conduction studies: Upper extremity nerve conduction studies including median-ulnar sensory and motor responses

Pressure pain threshold: Pain pressure threshold is used to measure deep muscular tissue pain sensitivity.

Study summary

This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms. Extra median sensory spread, observed in some CTS patients beyond the anatomical boundaries of the median nerve, may reflect central sensitization mechanisms. Using the Central Sensitization Inventory and pressure pain threshold measurements, this study will assess whether extra median symptom patterns are associated with increased central sensitization.

Eligibility

Primary outcome measure(s)

• Pressure pain threshold — 3 months
  Pain pressure threshold (PPT) is used to measure deep muscular tissue sensitivity. Algometer is used in the measurement and low values are interpreted in favor of increased sensitivity.
• Katz hand diagram — 3 months
  The Katz Hand Diagram is a self-reported symptom map used to support the diagnosis of Carpal Tunnel Syndrome (CTS). Patients are asked to mark areas on a standardized hand diagram where they experience pain, numbness, or tingling. This tool helps clinicians assess whether symptoms follow a median nerve distribution and is commonly used in both clinical and research settings due to its simplicity and diagnostic value.

Trial sites (1)

More Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey trials in Turkey

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