Target-Controlled Infusion (TCI) Effectiveness in Hysteroscopy

Condition(s) studied

Investigational drug(s) / intervention(s)

Schnider+ Mİnto: Patients assigned to the Standart TCI model Group would have Schnider + Minto models throughout the surgery. The patients would be monitorized with anesthesia depth, analgesia monitoring, NIRS, and recovery parameters.

Eleveld: Patients assigned to the Eleveld TCI model Group would have Eleveld+Eleveld models throughout the surgery. The patients would be monitorized with anesthesia depth, analgesia monitoring, NIRS, and recovery parameters.

Study summary

This prospective, randomized, observational study aims to evaluate the perioperative anesthetic efficacy of different Target-Controlled Infusion (TCI) models-specifically Minto, Schnider, and Eleveld pharmacokinetic models-in patients undergoing hysteroscopy under general anesthesia. 90 female patients will be randomized into two groups, each receiving different TCI model combinations for propofol and remifentanil. Primary outcomes include intraoperative consciousness (BIS/SEF), analgesia (ANI), tissue oxygenation (NIRS), and recovery parameters. The study seeks to identify model-specific benefits regarding patient and surgeon satisfaction, recovery time, and complication rates.

Eligibility

Primary outcome measure(s)

• Incidence of Intraoperative Complications — perioperative period: from beginning of anesthesia induction to discharge from recovery room
  Number of patients experiencing at least one predefined complication during anesthesia, including hypotension (MAP \<65 mmHg \>1 min), bradycardia (HR \<50 bpm), or oxygen desaturation (SpO₂ \<92%)
• Total Recovery Time Until Discharge Readiness — Up to 2 hours post-anesthesia
  Time elapsed from cessation of anesthetic agents to achieving an Aldrete score ≥9

Trial sites (1)

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