Morbid ObesityAnorectal DiseasesDrug-Related Side Effects and Adverse ReactionsConstipationDiarrhea
Investigational drug(s) / intervention(s)
GLP-1 receptor agonist therapy
GLP-1 receptor agonist therapy: Participants will receive GLP-1 receptor agonist treatment as part of routine clinical care. The study does not assign treatment but prospectively evaluates proctologic outcomes following treatment initiation.
Study summary
Prospective observational cohort study evaluating the early proctologic effects of GLP-1 receptor agonist therapy in morbidly obese patients. Participants will undergo baseline and 3-month anorectal symptom assessment and proctologic examination to evaluate newly developed proctologic diseases and changes in pre-existing symptoms.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age ≥18 years
* Morbid obesity (BMI ≥40 kg/m² or BMI ≥35 kg/m² with obesity-related comorbidities)
* Newly prescribed GLP-1 receptor agonist therapy
* Ability and willingness to provide written informed consent
* Ability to attend 3-month follow-up visit
Exclusion Criteria:
* Inflammatory bowel disease
* Perianal Crohn's disease
* History of anorectal malignancy
* Previous pelvic radiotherapy
* Anorectal surgery within the previous 3 months
* Pregnancy
* Neurogenic bowel dysfunction
* Inability to comply with follow-up visits
* Discontinuation of GLP-1 receptor agonist therapy before follow-up assessment
* Active anorectal infection or abscess
Primary outcome measure(s)
Incidence of newly developed proctologic disease — 3 months Patients developing newly diagnosed anorectal pathology after initiation of GLP-1 receptor agonist therapy, including hemorrhoidal disease, anal fissure, pruritus ani, perianal irritation, or other proctologic conditions identified during follow-up examination.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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