ECMO: ECMO implantation immediately after ICU admission
Study summary
This trial is a prospective randomized multicenter trial that assigns patients to either a treatment for Acute Respiratory Distress Syndrome (ARDS) with an Extracorporal Membrane Oxygenation (ECMO) immediately after admission to the intensive care unit or conservative treatment. The later can undergo ECMO following failure of conservative therapy as a rescue therapy. Patients will be included within 24 hours of the onset of symptoms of ARDS and will be randomized according to standard procedure. Follow-up will be performed until day 90 after study inclusion.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* ARDS as defined according to the Berlin Definition1
* The term "acute onset" is defined as follow: the duration of the hypoxemia criterion and the chest radiograph criterion must be ≤ 7 days at the time of randomization.
* Patients must be enrolled within 96 hours of onset of ARDS and no later than 7 days from the initiation of mechanical ventilation.
Exclusion Criteria:
* Age less than 18 years
* More than 7 days since initiation of mechanical ventilation
* more than 96 hours since meeting inclusion criteria
* patient, surrogate or physician not committed to full intensive care support
* pregnancy
Primary outcome measure(s)
90 day all cause mortality — 90 days after study inclusion 90 day all cause mortality
Trial sites (1)
Facility
City
Region
Status
University hospital Tübingen
Tübingen
Germany
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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