Reduction of Blood Recirculation in Veno-Venous ECMO

Condition(s) studied

Study summary

Blood which recirculates through the circuit of a veno-venous Extracorporeal Membrane Oxygenation (V-V ECMO) does not contribute to the systemic oxygenation of a patient on V-V ECMO and is called the recirculation fraction (Rf). Theoretically, the optimization of ECMO blood flow is possible using Rf measurements.

A prospective, observational study will be performed measuring the Rf of total ECMO blood flow in patients with acute respiratory distress syndrome (ARDS) on V-V ECMO with an ultrasound dilution technique.

ECMO blood flow will be optimized by reducing ECMO blood flow in accordance with the measured Rf as long as systemic oxygenation is not compromised.

Eligibility

Primary outcome measure(s)

• Successful ECMO blood flow reduction — Once within the first week after initiation of ECMO therapy
  Number of patients with a relevant recirculation fraction and successful ECMO blood flow reduction

Trial sites (1)

More Charite University, Berlin, Germany trials in Germany

Other trials for the same condition