Intrathecal Morphine: Patients will receive intrathecal morphine (0,3 mg) in 2 ml normal saline at the end of the operation through a 25G spinal needle through the lumbar intervertebral space (L3-L4 or L4-L5).
Intrathecal Dexmedetomidine: Patients will receive intrathecal 2 ml normal saline at the end of the operation through a 25G spinal needle through the lumbar intervertebral space (L3-L4 or L4-L5).
Normal Saline: Patients will receive intrathecal 2 ml normal saline at the end of the operation through a 25G spinal needle through the lumbar intervertebral space (L3-L4 or L4-L5).
Study summary
This study aims to compare the efficacy of intrathecal morphine and intrathecal dexmedetomidine in reducing pain following lumbar spine fixation surgeries.
Eligibility
Sex
ALL
Min age
21 Years
Max age
60 Years
Healthy volunteers
No
Inclusion Criteria:
* Aged between 21 and 60 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) Physical Status I or II.
* Scheduled for elective lumbar spine fixation surgery under general anesthesia.
Exclusion Criteria:
* Patients' refusal.
* Decompensated hepatic or renal or cardiac disease.
* Coagulation disorder.
* Pregnancy and lactation.
* Body mass index above 30 kg/m2.
* Severe pulmonary disorders.
* Patients on opioid, alcohol or allergy to any of the study drugs.
Primary outcome measure(s)
Time to the first rescue analgesia — 24 hours postoperatively Time to the first rescue analgesia will be recorded from the end of surgery till the first dose of pethidine adminstrated.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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