Successive Doses of GnRH Agonist Versus Single Dose of GnRH Agonist to Trigger Ovulation in Hyper-responders

Condition(s) studied

Investigational drug(s) / intervention(s)

Successive doses GnRH agonist: GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup. Two additional doses of triptorelin ( 0.1 mg / S.C ) are administered subcutaneously 12 and 24 hours after the first dose of GnRH agonist.

Single dose GnRH agonist: GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup.

Study summary

The aim of this randomized controlled study is to compare the efficacy of three successive doses of a GnRH agonist ( administered 36 , 24 and 12 hours before oocyte retrieval ) with a single dose of a GnRH agonist ( administered 36 hours before oocyte retrieval ) in triggering ovulation in hyper-responders

Eligibility

Primary outcome measure(s)

• Metaphase-II oocytes rate — Ten to fifteen days after starting ovarian stimulation
  Number of MII oocyte/ number of cumulus oocyte complex

Trial sites (1)

More Bedaya Hospital trials in Egypt

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