Triggering Oocyte Maturation in POSEIDON Group 3 and 4 Poor Responders Using Double Trigger or HCG Trigger

Condition(s) studied

Investigational drug(s) / intervention(s)

Double trigger: Triptorelin (0.2 mg/S.C ) and HCG (10000 IU/I.M) are administered 38 to 39 h and 35 to 36 h prior to ovum pick-up., respectively.

HCG trigger: HCG (10000 IU/I.M) is administered 35 to 36 h prior to ovum pick-up.

Study summary

The aim of this randomized controlled study is to compare the efficacy of double trigger protocol \[ the co-administration of GnRH agonist with HCG ( 38 - 39 and 35 - 36 h prior to ovum pick-up, respectively \] with HCG in triggering ovulation in patients with expected poor response to ovarian stimulation

Eligibility

Primary outcome measure(s)

• Metaphase-II oocytes rate — Ten to fifteen days after starting ovarian stimulation
  Number of MII oocyte/ number of cumulus oocyte complex

Trial sites (1)

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