Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger

Condition(s) studied

Investigational drug(s) / intervention(s)

Modified dual trigger: HCG (10000 IU /IM) and triptorelin (0.2 mg/S.C) are administered 36 hours before ovum pickup . Moreover, 0.1mg of triptorelin is administered 24 h prior to ovum pick-up.

HCG: HCG (10000 IU/IM ) is administered 36 hours before ovum pickup.

Study summary

The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol \[a single bolos of HCG combined with two successive doses of a GnRH agonist \] with HCG \[a single bolos administered 36 hours before oocyte retrieval \] in triggering ovulation in normo-responders undergoing ovarian stimulation using the antagonist protocol.

Eligibility

Primary outcome measure(s)

• Metaphase-II oocytes rate — Ten to fifteen days after starting ovarian stimulation
  Number of MII oocyte/ number of cumulus oocyte complex

Trial sites (1)

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