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Sponsor · clinical trials

argenx clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine and the EU Clinical Trials Information System (CTIS) — current trials in our USA, Spain, Italy, Poland, Germany, UK, France, Canada, Belgium, Austria, Japan, Netherlands, Czechia, China, Portugal, Australia, Denmark, Israel, South Korea, Sweden, Brazil, Ireland, Norway, Turkey, Mexico, Switzerland, Taiwan, Singapore and EU (CTIS) registers with argenx as lead sponsor. Synced 27 Sep 2026
44Current trials
23Recruiting now
6Drugs in these trials
29Trial registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov and CTIS registry records · Last verified · Editorial standards
At a glance

argenx is the lead sponsor of 44 current clinical trials in our USA, Spain, Italy, Poland, Germany, UK, France, Canada, Belgium, Austria, Japan, Netherlands, Czechia, China, Portugal, Australia, Denmark, Israel, South Korea, Sweden, Brazil, Ireland, Norway, Turkey, Mexico, Switzerland, Taiwan, Singapore and EU (CTIS) registers. 23 are recruiting patients now. The most common phase is Phase 3. The drugs named most often in its trials are Empasiprubart, Efgartigimod PH20 and Efgartigimod. The most-studied condition is gMG.

Company profile on this site (news, sites, medicines, approvals): Argenx (BE) →

ClinicalTrials.gov trials by status

  • Recruiting2359%
  • Not yet open25%
  • Active, closed1231%
  • By invitation25%

Trials by phase

  • Phase 31128%
  • Phase 21128%
  • Observational718%
  • Phase 1513%
  • Phase 2/3410%
  • Phase 413%
01

Clinical trials sponsored by argenx

39 on ClinicalTrials.gov
StudyPhaseStatusStartRegisters
A Study of Efgartigimod PH20 SC in Children Between 2 and Less Than 18 Years of Age With Generalized Myasthenia Gravis
NCT06392386 · Generalized Myasthenia Gravis
Phase 2/3 Recruiting 2024-06 UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Czechia, Canada, Australia, Israel
A Natural History Study in Participants With Congenital Myasthenic Syndromes (CMS) Due to Mutations in DOK7, MUSK, AGRN, or LRP4
NCT06078553 · Congenital Myasthenic Syndrome
Observational Recruiting 2024-02 UK, USA, Germany, France, Spain, Italy, Belgium, Poland, Austria, Canada, Brazil, Japan
ADAPT Forward 2 - ISA2 - a Study to Evaluate the Safety, Tolerability and Efficacy of Empasiprubart IV Monotherapy in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis
NCT07673627 · AChR-Ab Seropositive Generalized Myasthenia Gravis, Myasthenia Gravis (MG), MG - Myasthenia Gravis
Phase 2 Recruiting 2026-07 USA
A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia
NCT06544499 · ClinicalTrials.gov ↗ · Primary Immune Thrombocytopenia (ITP)
Phase 3 Recruiting 2024-10 Ireland, UK, USA, China, Germany, France, Spain, Italy, Poland, Austria, Czechia, Portugal
A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP
NCT06920004 · ClinicalTrials.gov ↗ · Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
Phase 3 Recruiting 2025-08 UK, USA, Germany, France, Spain, Italy, Netherlands, Sweden, Poland, Switzerland, Austria, Czechia, Norway, Portugal, Turkey, Canada, Brazil, Japan, South Korea, Singapore, Australia, Israel
A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP
NCT07091630 · ClinicalTrials.gov ↗ · Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Phase 3 Recruiting 2025-09 UK, USA, China, France, Italy, Netherlands, Denmark, Poland, Austria, Czechia, Brazil, Japan, South Korea, Singapore, Israel
A Study of Efgartigimod IV in Participants From 12 Years to Less Than 18 Years of Age With Chronic Immune Thrombocytopenia (ITP)
NCT07194850 · ClinicalTrials.gov ↗ · Immune Thrombocytopenia (ITP), ITP - Immune Thrombocytopenia, ITP
Phase 2/3 Recruiting 2025-10 UK, Germany, France, Spain, Italy, Poland, Japan
Real-World Efgartigimod Effectiveness in CIDP: A Prospective Study
NCT07264426 · Chronic Inflammatory Demyelinating Polyradiculoneuropathy, CIDP, CIDP (Chronic Inflammatory Demyelinating Polyradiculoneuropathy)
Observational Recruiting 2025-08 USA, Germany
A Worldwide Pregnancy Safety Study to Assess Maternal, Fetal, and Infant Outcomes Following Exposure to Efgartigimod During Pregnancy and/or Breastfeeding.
NCT06299748 · Myasthenia Gravis, CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
Observational Recruiting 2023-11 USA, Germany, Spain, Italy
A Study to Evaluate the Impact of Efgartigimod on Overall Disease Experience of People Suffering From Generalized Myasthenia Gravis (gMG) in Italy
NCT07595653 · ClinicalTrials.gov ↗ · Generalized Myasthenia Gravis (gMG), gMG
Observational Recruiting 2026-02 Italy
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
NCT06655155 · ClinicalTrials.gov ↗ · Systemic Sclerosis (SSc)
Phase 2 Recruiting 2024-11 UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Switzerland, Czechia, Portugal, Mexico
Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis
NCT04833894 · ClinicalTrials.gov ↗ · Generalized Myasthenia Gravis
Phase 2/3 Recruiting 2021-10 UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Austria, Canada
A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy
NCT07287982 · ClinicalTrials.gov ↗ · Spinal Muscular Atrophy (SMA)
Drug: ARGX-119
Phase 2 Recruiting 2025-12 UK, USA
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC PFS in Adult Participants With Graves' Disease.
NCT07596849 · ClinicalTrials.gov ↗ · Graves Disease
Phase 3 Recruiting 2026-06 Spain, Poland, Canada, Japan
A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa
NCT06298565 · ClinicalTrials.gov ↗ · Myasthenia Gravis
Observational Recruiting 2024-11 USA, Germany, Spain, Italy, Belgium, Austria, Israel
A Study to Assess the Bioequivalence of Efgartigimod PH20 SC Between Autoinjector and Prefilled Syringe in Healthy Adult Participants
NCT07782775 · ClinicalTrials.gov ↗ · Healthy Volunteer, Healthy Adult Participants
Phase 1 Recruiting 2026-06 Canada
ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis
NCT07294170 · ClinicalTrials.gov ↗ · Myasthenia Gravis, MG, gMG
Observational Recruiting 2025-12 USA, Germany, Spain, Italy, Belgium, Poland, Japan
ADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod
NCT07284420 · ClinicalTrials.gov ↗ · AChR-Ab Seropositive Generalized Myasthenia Gravis, Myasthenia Gravis, MG
Phase 2 Recruiting 2025-12 USA, Germany, Spain, Italy, Belgium, Poland, Japan
A Study to Assess the Safety of ARGX-124 in Healthy Volunteers
NCT07377396 · ClinicalTrials.gov ↗ · Healthy Volunteers
Phase 1 Recruiting 2026-01 Canada
A Study to Assess the Absolute Bioavailability of Empasiprubart SC Administered With an Autoinjector and the Pharmacokinetic Noninferiority of Empasiprubart SC Versus Intravenous (IV) in Healthy Adult Participants
NCT07612020 · ClinicalTrials.gov ↗ · Healthy Volunteers
Phase 1 Recruiting 2026-03 Canada
A Study to Evaluate the Clinical Outcomes of Efgartigimod PH20 SC in Adults With New-onset Generalized Myasthenia Gravis (gMG)
NCT06909214 · ClinicalTrials.gov ↗ · New Onset Generalized Myasthenia Gravis (gMG)
Phase 4 Recruiting 2025-04 USA
A Study to Assess the Absolute Bioavailability and How Adimanebart SC Moves Through the Body in Healthy Adult Participants
NCT07673601 · ClinicalTrials.gov ↗ · Healthy Volunteers (HV), Healthy Volunteer
Phase 1 Recruiting 2026-06 Canada
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC PFS in Adult Participants With Graves' Disease
NCT07570316 · ClinicalTrials.gov ↗ · Graves' Disease, Graves Disease
Phase 3 Recruiting 2026-06 USA
A Study to Learn About How Well the Medicine Efgartigimod Works to Treat Autoimmune Encephalitis In Children 12 Years or Older and Adults
NCT07583641 · Autoimmune Encephalitis (AE)
Phase 2 Not yet open 2027-04 USA
A Study to Evaluate the Effect of ARGX-121 on the Change in Proteinuria in Adult Participants With IgAN
NCT07773727 · ClinicalTrials.gov ↗ · Immunoglobulin A Nephropathy (IgAN)
Phase 2 Not yet open 2026-10 USA
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
NCT05979441 · Myositis, Active Idiopathic Inflammatory Myopathy, Dermatomyositis
Phase 3 By invitation 2023-09 Ireland, UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Portugal, Mexico, Japan, South Korea, Taiwan
Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children With Generalized Myasthenia Gravis
NCT05374590 · Generalized Myasthenia Gravis, gMG
Phase 2/3 By invitation 2022-08 UK, USA, Germany, France, Spain, Netherlands, Belgium, Poland, Canada, Israel
A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
NCT04812925 · Primary Immune Thrombocytopenia
Phase 3 Active, closed 2021-11 Ireland, UK, USA, China, Italy, Poland, Norway, Portugal, Turkey, Mexico, Japan, South Korea, Australia
A Clinical Trial to Investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults With Multifocal Motor Neuropathy
NCT05405361 · Multifocal Motor Neuropathy (MMN)
Phase 2 Active, closed 2023-01 UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Austria, Canada
A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis
NCT06298552 · Generalized Myasthenia Gravis, gMG, Myasthenia Gravis, Generalized
Phase 3 Active, closed 2024-04 UK, USA, China, Germany, France, Spain, Netherlands, Belgium, Denmark, Poland, Czechia, Norway, Portugal, Canada
ARGX-117 in Deceased Donor Kidney Transplant Recipients at Risk for Delayed Graft Function
NCT05907096 · ClinicalTrials.gov ↗ · Delayed Graft Function
Phase 2 Active, closed 2024-02 USA, France, Spain, Italy, Belgium, Sweden, Austria, Portugal, Canada, Brazil, Australia
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis
NCT06558279 · ClinicalTrials.gov ↗ · Myasthenia Gravis, Ocular
Phase 3 Active, closed 2024-09 UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Portugal, Canada, Japan, South Korea, Australia
A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome
NCT06684847 · ClinicalTrials.gov ↗ · Primary Sjogrens Disease
Phase 3 Active, closed 2025-01 Ireland, UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Poland, Austria, Portugal, Turkey, Canada, Mexico, Japan, South Korea, Australia, Israel
A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy
NCT06742190 · ClinicalTrials.gov ↗ · Multifocal Motor Neuropathy (MMN), MMN
Phase 3 Active, closed 2024-12 UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Switzerland, Austria, Czechia, Norway, Portugal, Canada, Brazil, Japan, Australia
A Phase 1b Study to Investigate Safety and Tolerability of ARGX-119 in Adult Participants With DOK7-Congenital Myasthenic Syndromes (CMS)
NCT06436742 · ClinicalTrials.gov ↗ · Congenital Myasthenic Syndrome, CMS
Drug: ARGX-119
Phase 1 Active, closed 2024-09 UK, USA, France, Spain, Italy, Canada
A Prospective Longitudinal Study in Adults With Multifocal Motor Neuropathy
NCT05988073 · ClinicalTrials.gov ↗ · Multifocal Motor Neuropathy
Observational Active, closed 2023-11 UK, USA, China, Germany, France, Spain, Italy, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Canada, Japan, Australia
A Study to Evaluate the Safety and Tolerability of Efgartigimod PH20 SC Given by Prefilled Syringe in Kidney Transplant Recipients With Antibody-Mediated Rejection (AMR)
NCT06503731 · ClinicalTrials.gov ↗ · Antibody-mediated Rejection
Phase 2 Active, closed 2024-08 USA, Germany, France, Spain, Belgium, Austria, Czechia, Canada
A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis
NCT06284954 · ClinicalTrials.gov ↗ · Dermatomyositis, Myositis
Phase 2 Active, closed 2024-08 USA, Spain, Italy, Poland
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP, an Autoimmune Disorder That Affects the Peripheral Nerves)
NCT04280718 · ClinicalTrials.gov ↗ · Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Phase 2 Active, closed 2020-09 UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Austria, Czechia, Turkey, Japan, Taiwan, Israel

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

02

argenx in the EU trials register (CTIS)

5 trials

Authorised or ongoing trials in the EU Clinical Trials Information System with argenx as sponsor. Some are the same study as a ClinicalTrials.gov record above; the two registries share no common ID. Trials with a site in Ireland are listed first.

StudyPhaseStatusCountries
A Phase 2, Randomized, Double-Blinded, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Efgartigimod PH20 Subcutaneous Administered by Prefilled Syringe in Adult Participants with Sjogren’s Disease-Associated Sensorimotor or Sensory Polyneuropathy
2026-526218-10-00 · Immune System Diseases
Phase 2 Authorised Germany, Estonia, Lithuania + 10 more
Master Protocol Full Title- A Master Protocol for an Exploratory, Phase 2a, Proof-of-Concept Platform Study to Evaluate the Safety, Tolerability, and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis. ISA 2 to Master Protocol ARGX-999-2-MG-2000 – an Exploratory, Phase 2a, Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Empasiprubart IV Monotherapy in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis
2025-522939-33-00 · Immune System Diseases
Phase 2 Ongoing Greece, Italy, Germany + 4 more
A Phase 3, Randomized, Double-Blinded, Placebo-Controlled Study Evaluating the Efficacy and Safety of Empasiprubart IV in Adults With Chronic Inflammatory Demyelinating Polyneuropathy
2025-520805-10-00 · CTIS ↗ · Nervous System Diseases
Phase 3 Ongoing Czechia, Denmark, Poland + 12 more
A Phase 3, Randomized, Double-Blinded, Double-Dummy Study Evaluating the Efficacy and Safety of Intravenous Empasiprubart Versus Intravenous Immunoglobulin in Adults With Chronic Inflammatory Demyelinating Polyneuropathy
2024-520097-36-00 · CTIS ↗ · Nervous System Diseases
Phase 3 Ongoing Czechia, Bulgaria, Netherlands + 16 more
ARGX-113-2409: A Multicenter, Randomized, Double-blinded, Parallel-Arm, Placebo- Controlled, Pharmacokinetic and Pharmacodynamic Study Followed by an Open-Label Arm to Evaluate Efgartigimod IV in Pediatric Participants from 12 Years to Less Than 18 Years of Age with Chronic ITP
2025-521055-23-00 · CTIS ↗ · Immune System Diseases
Phase 3 Ongoing Lithuania, Romania, Hungary + 5 more
03

Drugs in argenx trials

6 compounds

Drugs and biologicals named as interventions in these trials, with the number of this sponsor's trials that name each one. Placebos and generic comparators are excluded.

04

Conditions in argenx trials

45 conditions
gMG6Generalized Myasthenia Gravis5Myasthenia Gravis5CIDP3Myositis2Dermatomyositis2Congenital Myasthenic Syndrome2Multifocal Motor Neuropathy (MMN)2Chronic Inflammatory Demyelinating Polyneuropathy2CIDP - Chronic Inflammatory Demyelinating Polyneuropathy2Chronic Inflammatory Demyelinating Polyradiculoneuropathy2AChR-Ab Seropositive Generalized Myasthenia Gravis2MG2Graves Disease2Healthy Volunteer2Healthy Volunteers2Primary Immune Thrombocytopenia1Active Idiopathic Inflammatory Myopathy1Polymyositis1Primary Immune Thrombocytopenia (ITP)1Primary Sjogrens Disease1Myasthenia Gravis, Generalized1CMS1Immune Thrombocytopenia (ITP)1
05

By trial register

RegisterTrialsRecruiting
Clinical trials in USA3216
Clinical trials in Spain2512
Clinical trials in Italy2413
Clinical trials in Poland2211
Clinical trials in Germany2212
Clinical trials in UK209
Clinical trials in France208
Clinical trials in Canada199
Clinical trials in Belgium187
Clinical trials in Austria156
Clinical trials in Japan147
Clinical trials in Netherlands135
Clinical trials in Czechia125
Clinical trials in China102
Clinical trials in Portugal103
Clinical trials in Australia82
Clinical trials in Denmark82
Clinical trials in Israel74
Clinical trials in South Korea62
Clinical trials in Sweden61
Clinical trials in Brazil53
Clinical trials in Ireland41
Clinical trials in Norway41
Clinical trials in Turkey41
Clinical trials in Mexico41
Clinical trials in Switzerland43
Clinical trials in Taiwan20
Clinical trials in Singapore22
EU register (CTIS)5—

A trial with sites in more than one country appears in each of those registers.

06

Questions about argenx trials

How many clinical trials does argenx sponsor?

argenx is the lead sponsor of 39 current trials on ClinicalTrials.gov in our USA, Spain, Italy, Poland, Germany, UK, France, Canada, Belgium, Austria, Japan, Netherlands, Czechia, China, Portugal, Australia, Denmark, Israel, South Korea, Sweden, Brazil, Ireland, Norway, Turkey, Mexico, Switzerland, Taiwan and Singapore registers, and 5 authorised or ongoing trials in the EU register (CTIS), as of the registry sync on 27 September 2026. Completed and withdrawn studies are not counted.

Are argenx trials recruiting?

Yes. 23 of its 39 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Which drugs is argenx testing?

Its current trials name 6 drugs and biologicals as interventions. The most frequent are Empasiprubart (13), Efgartigimod PH20 (10), Efgartigimod (9), ARGX-119 (2) and IVIG (2). The number in brackets is how many of its trials name each drug.

Does argenx have clinical trials in Ireland?

Yes. 4 trials in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

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How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 27 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.