|
A Study of Efgartigimod PH20 SC in Children Between 2 and Less Than 18 Years of Age With Generalized Myasthenia Gravis
|
Phase 2/3 |
Recruiting |
2024-06 |
UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Czechia, Canada, Australia, Israel |
|
A Natural History Study in Participants With Congenital Myasthenic Syndromes (CMS) Due to Mutations in DOK7, MUSK, AGRN, or LRP4
|
Observational |
Recruiting |
2024-02 |
UK, USA, Germany, France, Spain, Italy, Belgium, Poland, Austria, Canada, Brazil, Japan |
ADAPT Forward 2 - ISA2 - a Study to Evaluate the Safety, Tolerability and Efficacy of Empasiprubart IV Monotherapy in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis
NCT07673627 · AChR-Ab Seropositive Generalized Myasthenia Gravis, Myasthenia Gravis (MG), MG - Myasthenia Gravis
|
Phase 2 |
Recruiting |
2026-07 |
USA |
A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia
NCT06544499 · ClinicalTrials.gov ↗ · Primary Immune Thrombocytopenia (ITP)
|
Phase 3 |
Recruiting |
2024-10 |
Ireland, UK, USA, China, Germany, France, Spain, Italy, Poland, Austria, Czechia, Portugal |
A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP
NCT06920004 · ClinicalTrials.gov ↗ · Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
|
Phase 3 |
Recruiting |
2025-08 |
UK, USA, Germany, France, Spain, Italy, Netherlands, Sweden, Poland, Switzerland, Austria, Czechia, Norway, Portugal, Turkey, Canada, Brazil, Japan, South Korea, Singapore, Australia, Israel |
A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP
NCT07091630 · ClinicalTrials.gov ↗ · Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
|
Phase 3 |
Recruiting |
2025-09 |
UK, USA, China, France, Italy, Netherlands, Denmark, Poland, Austria, Czechia, Brazil, Japan, South Korea, Singapore, Israel |
A Study of Efgartigimod IV in Participants From 12 Years to Less Than 18 Years of Age With Chronic Immune Thrombocytopenia (ITP)
NCT07194850 · ClinicalTrials.gov ↗ · Immune Thrombocytopenia (ITP), ITP - Immune Thrombocytopenia, ITP
|
Phase 2/3 |
Recruiting |
2025-10 |
UK, Germany, France, Spain, Italy, Poland, Japan |
Real-World Efgartigimod Effectiveness in CIDP: A Prospective Study
NCT07264426 · Chronic Inflammatory Demyelinating Polyradiculoneuropathy, CIDP, CIDP (Chronic Inflammatory Demyelinating Polyradiculoneuropathy)
|
Observational |
Recruiting |
2025-08 |
USA, Germany |
A Worldwide Pregnancy Safety Study to Assess Maternal, Fetal, and Infant Outcomes Following Exposure to Efgartigimod During Pregnancy and/or Breastfeeding.
NCT06299748 · Myasthenia Gravis, CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
|
Observational |
Recruiting |
2023-11 |
USA, Germany, Spain, Italy |
A Study to Evaluate the Impact of Efgartigimod on Overall Disease Experience of People Suffering From Generalized Myasthenia Gravis (gMG) in Italy
NCT07595653 · ClinicalTrials.gov ↗ · Generalized Myasthenia Gravis (gMG), gMG
|
Observational |
Recruiting |
2026-02 |
Italy |
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
NCT06655155 · ClinicalTrials.gov ↗ · Systemic Sclerosis (SSc)
|
Phase 2 |
Recruiting |
2024-11 |
UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Switzerland, Czechia, Portugal, Mexico |
Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis
NCT04833894 · ClinicalTrials.gov ↗ · Generalized Myasthenia Gravis
|
Phase 2/3 |
Recruiting |
2021-10 |
UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Austria, Canada |
A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy
NCT07287982 · ClinicalTrials.gov ↗ · Spinal Muscular Atrophy (SMA)
|
Phase 2 |
Recruiting |
2025-12 |
UK, USA |
|
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC PFS in Adult Participants With Graves' Disease.
|
Phase 3 |
Recruiting |
2026-06 |
Spain, Poland, Canada, Japan |
|
A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa
|
Observational |
Recruiting |
2024-11 |
USA, Germany, Spain, Italy, Belgium, Austria, Israel |
A Study to Assess the Bioequivalence of Efgartigimod PH20 SC Between Autoinjector and Prefilled Syringe in Healthy Adult Participants
NCT07782775 · ClinicalTrials.gov ↗ · Healthy Volunteer, Healthy Adult Participants
|
Phase 1 |
Recruiting |
2026-06 |
Canada |
ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis
NCT07294170 · ClinicalTrials.gov ↗ · Myasthenia Gravis, MG, gMG
|
Observational |
Recruiting |
2025-12 |
USA, Germany, Spain, Italy, Belgium, Poland, Japan |
ADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod
NCT07284420 · ClinicalTrials.gov ↗ · AChR-Ab Seropositive Generalized Myasthenia Gravis, Myasthenia Gravis, MG
|
Phase 2 |
Recruiting |
2025-12 |
USA, Germany, Spain, Italy, Belgium, Poland, Japan |
A Study to Assess the Safety of ARGX-124 in Healthy Volunteers
NCT07377396 · ClinicalTrials.gov ↗ · Healthy Volunteers
|
Phase 1 |
Recruiting |
2026-01 |
Canada |
A Study to Assess the Absolute Bioavailability of Empasiprubart SC Administered With an Autoinjector and the Pharmacokinetic Noninferiority of Empasiprubart SC Versus Intravenous (IV) in Healthy Adult Participants
NCT07612020 · ClinicalTrials.gov ↗ · Healthy Volunteers
|
Phase 1 |
Recruiting |
2026-03 |
Canada |
A Study to Evaluate the Clinical Outcomes of Efgartigimod PH20 SC in Adults With New-onset Generalized Myasthenia Gravis (gMG)
NCT06909214 · ClinicalTrials.gov ↗ · New Onset Generalized Myasthenia Gravis (gMG)
|
Phase 4 |
Recruiting |
2025-04 |
USA |
A Study to Assess the Absolute Bioavailability and How Adimanebart SC Moves Through the Body in Healthy Adult Participants
NCT07673601 · ClinicalTrials.gov ↗ · Healthy Volunteers (HV), Healthy Volunteer
|
Phase 1 |
Recruiting |
2026-06 |
Canada |
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC PFS in Adult Participants With Graves' Disease
NCT07570316 · ClinicalTrials.gov ↗ · Graves' Disease, Graves Disease
|
Phase 3 |
Recruiting |
2026-06 |
USA |
|
A Study to Learn About How Well the Medicine Efgartigimod Works to Treat Autoimmune Encephalitis In Children 12 Years or Older and Adults
|
Phase 2 |
Not yet open |
2027-04 |
USA |
A Study to Evaluate the Effect of ARGX-121 on the Change in Proteinuria in Adult Participants With IgAN
NCT07773727 · ClinicalTrials.gov ↗ · Immunoglobulin A Nephropathy (IgAN)
|
Phase 2 |
Not yet open |
2026-10 |
USA |
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
NCT05979441 · Myositis, Active Idiopathic Inflammatory Myopathy, Dermatomyositis
|
Phase 3 |
By invitation |
2023-09 |
Ireland, UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Portugal, Mexico, Japan, South Korea, Taiwan |
|
Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children With Generalized Myasthenia Gravis
|
Phase 2/3 |
By invitation |
2022-08 |
UK, USA, Germany, France, Spain, Netherlands, Belgium, Poland, Canada, Israel |
|
A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
|
Phase 3 |
Active, closed |
2021-11 |
Ireland, UK, USA, China, Italy, Poland, Norway, Portugal, Turkey, Mexico, Japan, South Korea, Australia |
|
A Clinical Trial to Investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults With Multifocal Motor Neuropathy
|
Phase 2 |
Active, closed |
2023-01 |
UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Austria, Canada |
A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis
NCT06298552 · Generalized Myasthenia Gravis, gMG, Myasthenia Gravis, Generalized
|
Phase 3 |
Active, closed |
2024-04 |
UK, USA, China, Germany, France, Spain, Netherlands, Belgium, Denmark, Poland, Czechia, Norway, Portugal, Canada |
ARGX-117 in Deceased Donor Kidney Transplant Recipients at Risk for Delayed Graft Function
NCT05907096 · ClinicalTrials.gov ↗ · Delayed Graft Function
|
Phase 2 |
Active, closed |
2024-02 |
USA, France, Spain, Italy, Belgium, Sweden, Austria, Portugal, Canada, Brazil, Australia |
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis
NCT06558279 · ClinicalTrials.gov ↗ · Myasthenia Gravis, Ocular
|
Phase 3 |
Active, closed |
2024-09 |
UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Portugal, Canada, Japan, South Korea, Australia |
A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome
NCT06684847 · ClinicalTrials.gov ↗ · Primary Sjogrens Disease
|
Phase 3 |
Active, closed |
2025-01 |
Ireland, UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Poland, Austria, Portugal, Turkey, Canada, Mexico, Japan, South Korea, Australia, Israel |
A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy
NCT06742190 · ClinicalTrials.gov ↗ · Multifocal Motor Neuropathy (MMN), MMN
|
Phase 3 |
Active, closed |
2024-12 |
UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Switzerland, Austria, Czechia, Norway, Portugal, Canada, Brazil, Japan, Australia |
A Phase 1b Study to Investigate Safety and Tolerability of ARGX-119 in Adult Participants With DOK7-Congenital Myasthenic Syndromes (CMS)
NCT06436742 · ClinicalTrials.gov ↗ · Congenital Myasthenic Syndrome, CMS
|
Phase 1 |
Active, closed |
2024-09 |
UK, USA, France, Spain, Italy, Canada |
A Prospective Longitudinal Study in Adults With Multifocal Motor Neuropathy
NCT05988073 · ClinicalTrials.gov ↗ · Multifocal Motor Neuropathy
|
Observational |
Active, closed |
2023-11 |
UK, USA, China, Germany, France, Spain, Italy, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Canada, Japan, Australia |
A Study to Evaluate the Safety and Tolerability of Efgartigimod PH20 SC Given by Prefilled Syringe in Kidney Transplant Recipients With Antibody-Mediated Rejection (AMR)
NCT06503731 · ClinicalTrials.gov ↗ · Antibody-mediated Rejection
|
Phase 2 |
Active, closed |
2024-08 |
USA, Germany, France, Spain, Belgium, Austria, Czechia, Canada |
A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis
NCT06284954 · ClinicalTrials.gov ↗ · Dermatomyositis, Myositis
|
Phase 2 |
Active, closed |
2024-08 |
USA, Spain, Italy, Poland |
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP, an Autoimmune Disorder That Affects the Peripheral Nerves)
NCT04280718 · ClinicalTrials.gov ↗ · Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
|
Phase 2 |
Active, closed |
2020-09 |
UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Austria, Czechia, Turkey, Japan, Taiwan, Israel |