Knee Arthritis, OsteoarthritisOsteo Arthritis of the Knee
Study summary
The purpose of this cross-sectional, observational study is to evaluate the relationship between quadriceps muscle quality-specifically muscle echogenicity and thickness change during isometric contraction-and clinical outcomes such as pain, physical function, quality of life, and Patient Global Assessment (PtGA) in female patients with knee osteoarthritis. Participants will undergo a non-invasive ultrasound evaluation of their thigh muscles and complete standard clinical questionnaires to help determine how muscle structural and functional properties impact the daily lives of patients with knee osteoarthritis.
Eligibility
Sex
FEMALE
Min age
40 Years
Max age
70 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Female sex
* Aged between 40 and 70 years
* Diagnosed with clinical and radiographic primary knee osteoarthritis (Kellgren-Lawrence Grade 2 or 3)
* Ability to perform isometric contraction at 90° of knee flexion
* Voluntary participation and provision of written informed consent
Exclusion Criteria:
* History of knee surgery within the last 6 months
* Intra-articular injection (e.g., corticosteroids, hyaluronic acid) within the last 3 months
* Presence of inflammatory rheumatic diseases (e.g., Rheumatoid Arthritis, Spondyloarthropathy)
* Known neuromuscular disorders affecting the lower extremities
* Severe cardiopulmonary comorbidities that prevent participation in clinical assessments
* Severe patellofemoral instability
Primary outcome measure(s)
Knee Injury and Osteoarthritis Outcome Score - Physical Function Short Form (KOOS-PS) — Baseline The primary outcome is physical function, reflecting the capacity to perform activities of daily living. KOOS-PS is a 7-item patient-reported measure assessing functional difficulties (e.g., getting in/out of bed, putting on socks, squatting). Scores for each item range from 0 to 4, and the total score is transformed to a 0-100 scale. A higher score indicates better physical function.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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