Preventing Muscle Loss After Bariatric Surgery: Protein-Collagen Supplementation and Resistance Exercise

Condition(s) studied

Investigational drug(s) / intervention(s)

Whey protein supplement: Oral whey protein supplement provided daily according to bariatric surgery nutrition protocol.

Hydrolyzed Collagen Supplement: Oral hydrolyzed collagen supplement provided daily in combination with whey protein.

Vitamin and Mineral Supplementation: Routine vitamin and mineral supplementation according to bariatric surgery follow-up protocol.

Resistance Exercise Program: Structured resistance exercise program initiated at postoperative week 4, supervised, 3 times per week.

Study summary

The aim of this clinical trial is to investigate the effectiveness of collagen, considered a new approach to prevent muscle mass loss after bariatric surgery, and to demonstrate the relationship between this effect and exercise. The key questions it aims to answer are:

Does whey protein supplementation with collagen combined with resistance exercise prevent muscle mass loss after bariatric surgery? Do whey protein supplementation with collagen combined with resistance exercise affect fat mass after bariatric surgery?

Researchers will compare collagen with whey protein.

The study groups and interventions to be implemented are summarized below:

Group 1: Control Group (CG; n: 10) Whey protein supplementation will be administered Vitamin and mineral supplementation will be administered No resistance exercise will be performed The participants will eat according to bariatric surgery nutrition guidelines and perform physical activities.

Group 2: Whey Protein + Collagen + Exercise Group (WPCEG; n: 10) Whey protein supplements with collagen will be given. Vitamin and mineral supplements will be given. Resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities.

They will begin a resistance exercise program 4 weeks after surgery.

Group 3: Whey Protein + Collagen + No Exercise Group (WPCG; n: 10) Whey protein supplements with collagen will be given. Vitamin and mineral supplements will be given. No resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities.

Group 4: Whey Protein + Exercise Group (WPEG; n: 10) Whey protein supplements will be given. Vitamin and mineral supplements will be given. Resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities.

A resistance exercise program will begin at 4 weeks post-operatively.

Eligibility

Primary outcome measure(s)

• Change in Skeletal Muscle Mass (kg) Measured by BIA — Baseline (preoperative), postoperative week 4 (day 29), and postoperative week 12 (day 85)
  Skeletal muscle mass (kg) will be measured using a multi-frequency bioelectrical impedance analysis (BIA) device. The outcome will be reported as the mean change from baseline at each time point in each study group.

Trial sites (1)

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