One-Year Outcomes After Conversion Bariatric Surgery

Condition(s) studied

Study summary

Obesity is a growing global public health problem, and bariatric surgery is currently the most effective treatment for achieving sustained weight loss and improving obesity-related comorbidities. However, a subset of patients experience inadequate weight loss or weight regain following primary bariatric surgery, which may lead to the recurrence of metabolic complications and reduced quality of life. In such cases, conversion bariatric surgery, defined as the surgical conversion from one bariatric procedure to another, is considered an important therapeutic option. Despite the increasing number of conversion procedures, comprehensive longitudinal data evaluating anthropometric, biochemical, and nutritional outcomes after conversion bariatric surgery remain limited.

This study aims to prospectively evaluate individuals undergoing conversion bariatric surgery due to weight regain following primary bariatric surgery. Anthropometric measurements, biochemical parameters, and nutritional status will be assessed preoperatively and at 1 year after surgery. By evaluating weight loss outcomes together with metabolic and nutritional changes, this study seeks to provide clinically relevant evidence to guide postoperative follow-up strategies, optimize nutritional management, and support multidisciplinary care in patients undergoing conversion bariatric surgery.

Eligibility

Primary outcome measure(s)

• Change in Body Composition Parameters — Preoperative baseline and postoperative 1 year
  Body composition parameters including fat mass, fat percentage, fat-free mass, fat-free mass percentage, skeletal muscle mass, muscle percentage, and extracellular water to total body water ratio assessed using multi-frequency bioelectrical impedance analysis (BIA).
• Change in Body Weight — Preoperative baseline and postoperative 1 year
  Change in body weight (kg) measured using a digital scale with participants wearing light clothing and no shoes.
• Change in Body Mass Index (BMI) — Preoperative baseline and postoperative 1 year
  Change in body mass index (kg/m²) calculated from measured body weight and height.
• Percentage of Total Weight Loss — postoperative 1 year
  Percentage of total weight loss calculated as \[(preoperative weight - postoperative weight) / preoperative weight\] × 100.
• Percentage of Excess Weight Loss — postoperative 1 year
  Percentage of excess weight loss calculated as \[(preoperative weight - postoperative weight) / (preoperative weight - ideal body weight)\] × 100, with ideal body weight defined as a BMI of 25 kg/m².
• Change in Waist Circumference — Preoperative baseline and postoperative 1 year
  Waist circumference (cm) measured in the standing position using a non-elastic measuring tape at the midpoint between the lowest rib and the iliac crest.
• Change in Hip Circumference — Preoperative baseline and postoperative 1 year
  Hip circumference (cm) measured in the standing position at the point of maximum protrusion of the gluteal muscles using a non-elastic measuring tape.
• Change in Body Fat Percentage (%) — Preoperative baseline and postoperative 1 year
  Body fat percentage measured using multi-frequency bioelectrical impedance analysis (BIA).
• Change in Fat-Free Mass (kg) — Preoperative baseline and postoperative 1 year
  Fat-free mass measured using multi-frequency bioelectrical impedance analysis (BIA).
• Change in Skeletal Muscle Mass (kg) — Preoperative baseline and postoperative 1 year
  Skeletal muscle mass measured using multi-frequency bioelectrical impedance analysis (BIA).

Trial sites (1)

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