MAP 55-65 mmHg: MAP will be maintained between 55-65 mmHg during anesthesia.
MAP 66-75 mmHg: MAP will be maintained between 66-75 mmHg during anesthesia.
Study summary
Controlled hypotension is currently used in spinal surgery to reduce bleeding at the surgical site, improve the surgeon's visibility, and decrease intraoperative blood loss. Although controlled hypotension is considered a beneficial method from a surgical perspective, it is important to be cautious about its side effects. One such side effect is cerebral perfusion insufficiency, which can be managed by monitoring cerebral circulation through regional cerebral oxygen saturation (rSO2).
The aim of this study is to compare the effects of controlled hypotension at specific MAP ranges on cerebral oxygen saturation.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Aged 18-65 years
* ASA I-III risk group
* BMI between 18-40
* Baseline blood pressure below 140/90 mmHg
* Scheduled to undergo spinal surgery (2-4 level instrumentation)
Exclusion Criteria:
* Below 18 or above 65 years old
* Advanced comorbidities
* ASA IV or higher
* Baseline blood pressure above 140/90 mmHg
* History of bleeding diathesis
* Use of anticoagulant medications
* BMI below 18 or above 40
* History of previous spinal surgery
Primary outcome measure(s)
Near infrared spectroscopy (NIRS) — 5 minutes before induction of anesthesia cerebral oxygen saturation
Near infrared spectroscopy (NIRS) — 5 minutes after intubation cerebral oxygen saturation
Near infrared spectroscopy (NIRS) — 5 minutes after positioning prone cerebral oxygen saturation
Near infrared spectroscopy (NIRS) — 1 minutes after first surgical incision is made cerebral oxygen saturation
Near infrared spectroscopy (NIRS) — the time after one minutes target MAP value cerebral oxygen saturation
Near infrared spectroscopy (NIRS) — the time after ten minutes target MAP value cerebral oxygen saturation
Near infrared spectroscopy (NIRS) — the time after 20 minutes target MAP value cerebral oxygen saturation
Near infrared spectroscopy (NIRS) — 5 minutes after extubation cerebral oxygen saturation
Near infrared spectroscopy (NIRS) — postextubation after 15 minutes cerebral oxygen saturation
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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