The aim of this observational study is to investigate whether GDF-15 levels can predict clinical outcome in patients admitted to the intensive care unit with a diagnosis of septic shock.
The main question is:
* Can the level of GDF-15 levels during ICU admission predict the development of multiple organ failure in patients with septic shock? All patients will continue to receive routine treatment for sepsis and septic shock. The investigators will observe the development of multiple organ failure by the Sequential Organ Failure Assessment (SOFA) score increase
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients older thab 18 years of age
* Patients with septic shock
* Patients without end-stage renal failure (KDIGO G4,G5)
* Patients without chronic liver disease
* Patients with New York Heart Association (NYHA) stage 1-2
* Patients not diagnosed with active cancer
* Non-pregnant patients
* Patients without chronic immunodeficiency
* Patients without chronic inflammatory disease
Exclusion Criteria:
* Patients younger than 18 years age
* Patients not diagnosed with septic shock
* Patients with end-stage renal failure
* Patients with chronic liver disease
* Patients with New York Heart Association (NYHA) stage 3-4
* Patients diagnosed with active cancer
* Pregnant patients
* Patients with chronic immunodeficiency
* Patients with chronic inflammatory diseases
Primary outcome measure(s)
Predicting the progression to multiple organ failure in patients admitted to intensive care unit with septic shock by GDF-15 level — Time from intensive care unit admission to mortality at the 28th day. Sequential Organ Failure Assessment (SOFA) score is a computational score used to assess the status of organ systems. The SOFA is based on six different scores scored from 0 to 4 for each of the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems, with an increasing score reflecting worsening organ dysfunction. In the research, sepsis treatment and appropriate haemodynamic support treatment will be provided to patients and daily sofa score follow-up will be performed. Progression to multiple organ failure will be monitored with the sofa score.
Trial sites (1)
Facility
City
Region
Status
Ankara Bilkent City Hospital
Ankara
Turkey (Türkiye)
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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