Manual Mask Ventilation: Patients will receive manual mask ventilation with 100% oxygen using a reservoir bag. This procedure will be performed by an experienced anesthesiologist or anesthesia resident for 2 minutes following the administration of induction agents, allowing for adequate muscle relaxation prior to endotracheal intubation.
AutoFlow Mechanical Mask Ventilation: Patients will receive mask ventilation delivered mechanically by the anesthesia workstation. The device will provide 100% oxygen for 2 minutes following the administration of induction agents. The ventilator settings will be standardized to an AutoFlow mode with a tidal volume (VT) of 6 mL/kg (based on ideal body weight), a respiratory rate of 12 breaths/minute, a peak pressure limit of 30 cmH₂O, and a Positive End-Expiratory Pressure (PEEP) of 5 cmH₂O
Study summary
The objective of this study is to compare the effects of manual ventilation and AutoFlow ventilation, administered during the induction of general anesthesia, on cerebral (s-rSO₂) and peripheral (somatic) oxygenation (p-rSO₂) in geriatric patients.
Eligibility
Sex
ALL
Min age
65 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients aged 65 years and older.
* Patients scheduled to undergo elective surgery requiring endotracheal intubation under general anesthesia.
* Patients with an American Society of Anesthesiologists (ASA) physical status of I, II, or III.
* Volunteer patients who are willing to participate and provide written informed consent.
Exclusion Criteria:
* Patients with severe heart failure or severe pulmonary disease.
* Patients with a presence or history of brain tumors or cerebrovascular accidents (CVA/stroke).
* Patients with impaired cooperation or cognitive dysfunction (e.g., dementia, delirium, Alzheimer's disease).
* Patients with a known history or preoperative prediction of a difficult airway.
* Patients with a known allergy to the monitoring sensor materials.
Primary outcome measure(s)
Change in Cerebral Regional Oxygen Saturation (s-rSO2) — Baseline prior to pre-oxygenation (T1), immediately after pre-oxygenation (T2), post-induction/pre-intubation following 2 minutes of mask ventilation (T3), and immediately post-intubation (T4). Bilateral cerebral regional oxygen saturation will be continuously measured using a Near-Infrared Spectroscopy (NIRS) device (INVOS™ oximeter) with sensors placed on the right and left frontal regions. The changes in s-rSO2 values will be recorded to evaluate the impact of manual versus AutoFlow mask ventilation during the induction of general anesthesia.
Trial sites (1)
Facility
City
Region
Status
Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation
Ankara
Çankaya
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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