Breast NeoplasmsBody CompositionSarcopeniaFat RedistributionLymphedema
Study summary
This observational cohort study aims to track longitudinal changes in body composition, including skeletal muscle mass and fat distribution, in patients diagnosed with breast cancer. Following primary surgery and adjuvant therapy, participants will be monitored over a 2-year period.
The primary objective is to evaluate the natural progression of skeletal muscle mass index (SMI) and metabolic changes in this population. By conducting serial measurements, this study seeks to characterize the longitudinal trends in muscle loss and body composition shifts post-treatment, providing data to better understand the physiological impact of the cancer recovery process.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* \>18 years of age
* Diagnosed with stage I-III non-metastatic breast cancer within 12 months of diagnosis
* Scheduled for surgery, chemotherapy, with or without radiotherapy or targeted therapy.
Exclusion Criteria:
* Women diagnosed with metastatic (stage IV) breast cancer
* Women planning to move away from the area or be away for more than 6 months during the study period
* Women planning to become pregnant during the study period
* Implantable devices (e.g., pacemaker, nerve stimulator) or surgical implants (e.g., total hip or knee replacements)
Primary outcome measure(s)
Change in Skeletal Muscle Mass Index (SMI) — Baseline, within 2 weeks after final chemotherapy cycle, within 2 weeks after final radiotherapy session, and 6 months following surgery. Skeletal Muscle Mass Index (SMI) is the primary metric for assessing muscle mass. It is a composite value calculated by dividing total skeletal muscle mass (kg), as measured by multifrequency bioelectrical impedance analysis (ACCUNIQ BC720; SELVAS Healthcare), by the square of the participant's height (m2). Weight and height are measured at each time point to calculate this single aggregated value (kg/m2). Higher scores indicate greater muscle mass relative to height (better outcome).Unit of Measure: kg/m2
Trial sites (1)
Facility
City
Region
Status
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
New Taipei City
Xindian Dist
Recruiting
More Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation trials in Taiwan
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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