20 Hz rTMS: 20 Hz repetitive transcranial magnetic stimulation
Study summary
Laboratory studies have shown that prolonged continuous theta burst stimulation (pcTBS) provides better pain relief than 10 Hz repetitive transcranial magnetic stimulation (rTMS), with a shorter stimulation time, making it more practical for clinical use. Chemotherapy-induced peripheral neuropathy often causes neuropathic pain in cancer patients. The aims of this study are:
1. To compare the effects of pcTBS and 20 Hz rTMS on chemotherapy-induced peripheral neuropathy;
2. To compare the effects of pcTBS applied to the primary motor cortex versus the dorsolateral prefrontal cortex on neuropathic pain as well as depression and anxiety.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* breast cancer patients aged between 18- and 80-years-old with CIPN
* history of receiving chemotherapy including taxane-based neurotoxic agents
* with neuropathic pain, score≥3 in a 0-10 VAS pain scale.
* with fair cognition and can cooperate to evaluate pain severity.
* neither at end-stage cancer nor at the estimated survival time less than 6 months.
Exclusion Criteria:
* brain tumor or history of epilepsy
* intracranial metallic devices, artificial cochleae, pacemakers, or any other metal device
* recent myocardial ischemia or unstable angina
* severe cognitive dysfunction or pregnancy
* injuries or fractures in the part of neuropathic pain
Primary outcome measure(s)
visual analogue pain scale (VAS pain scale) — baseline, pre-intervention and immediately after completion the intervention and at 4 weeks follow-up visual analogue pain scale (VAS) range from 0-100, with a higher score inducating more pain
Trial sites (1)
Facility
City
Region
Status
Taipei Tzu Chi Hospital
New Taipei City
Taiwan
More Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation trials in Taiwan
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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