Low to Moderate Load Power Training for Men With Metastatic Prostate Cancer.

Condition(s) studied

Investigational drug(s) / intervention(s)

Power training group: The intervention consists of a supervised power-oriented resistance training program for older men with prostate cancer undergoing androgen deprivation therapy (ADT). Participants will complete 2 sessions per week over 24 weeks. Training focuses on improving muscle power through exercises performed at moderate intensity (40-50% 1RM), emphasizing a fast concentric phase and controlled eccentric phase. Multi-joint functional exercises targeting major muscle groups are included to enhance strength, balance, and daily functional performance. Training volume is low-to-moderate, and participants do not train to muscular failure, allowing maintenance of movement velocity and reducing fatigue. Adequate rest periods are provided between sets. The program is adapted to the clinical characteristics of the population, minimizing mechanical stress while promoting neuromuscular improvements. It is designed to be safe, feasible, and well-tolerated, with the aim of improving functional capacity.

Study summary

The goal of this clinical trial is to learn if a low to moderate load power training program is feasible and effective for improving fitness and quality of life of people with prostate cancer under androgen suppression therapy and bone or lymph node metastasis. The main questions it aims to answer are:

* Does a low to moderate load power training program improve quality of life in people with metastatic prostate cancer under androgen deprivation therapy?
* Does a low to moderate load power training program improve power, strength, endurance, and balance in people with metastatic prostate cancer under androgen deprivation therapy?

Researchers will compare the exercise program with routine care to see if power training works to improve common physical side effects of androgen suppression therapy in patients with metastatic prostate cancer.

Participants will:

* Participate in a supervised exercise program twice a week for 6 months or maintain routine care.
* Perform fitness tests and questionnaires about quality of life and mental health.
* Those who take part in the exercise program will also perform semi-structured in-depth interviews after the end of the program.

Eligibility

Primary outcome measure(s)

• Health-related quality of life — From enrollment to the end of the exercise program at 6 months.
  Quality of life will be assessed using the Functional Assessment of Cancer Therapy-Prostate (FACT-P) questionnaire. This instrument includes the Functional Assessment of Cancer Therapy-General (FACT-G) and a prostate cancer-specific subscale, providing a multidimensional assessment of physical, social/family, emotional, and functional well-being, as well as prostate cancer-related symptoms and concerns. The total score will be used for analysis, with higher scores indicating better quality of life. Results will be expressed in points, with a score range of 0 to 156. In addition, quality of life will be complemented by a final semi-structured interview exploring participants' perceptions and experiences after the intervention.

Trial sites (1)

More University of Alicante trials in Spain

Other trials for the same condition