Terahertz (THz) scanning using THz Imaging system.
Terahertz (THz) scanning using THz Imaging system.: The Terahertz (THz) scanning system is non-invasive and non-contact. It is a prototype developed by Institute of Materials Research and Engineering (IMRE), A\*STAR, Singapore and is performed for the purpose of research. THz scanning will provide safety data in human and the measurement of cornea hydration status. Each THz scan will take approximately 1 second. Real-time data will be generated when participants are positioned in front of the device.
Study summary
This observational study aims to establish the safety profile of the use of Terahertz (THz) scanning system on corneal diseases. Participants with "non-seeing" eyes but normal corneas will undergo THz scanning. Eye examinations will be conducted at baseline, immediately after scanning, and at 1 day, 1 week, and 1 month post-scanning. These examinations will include measurements of visual acuity, eye structural, retinal health, corneal cell morphology, and corneal nerve status. The investigators hypothesize that the THz scanning system is safe for application to the human cornea.
Eligibility
Sex
ALL
Min age
21 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Be at least 21 years of age
* Regardless of gender (Male/Female)
* Regardless of race (Chinese/Malay/Indian/Eurasian/Others)
* Willingness and ability to follow all instructions and comply with study schedule for study visit
* Have at least 1 eye (Study eye) that is deemed functionally blind but contain healthy corneas
* Ability to hold face sufficiently stable to undergo necessary scans
* Best Spectacle Corrected Visual Acuity (BSCVA) in the study eye of hand motion or worse
Exclusion Criteria:
* Pregnant/Breast-feeding women
* Eyes with previous major surgery on the cornea such as corneal transplantation, refractive surgery, corneal cross-linking procedure
* Eyes with previous infectious keratitis
* Eyes with long-term use of glaucoma eye drops
* Eyes with known moderate or server meibomian gland dysfunction
* Eyes with active inflammation or infection, or chronic ocular surface inflammation
* Systemic diseases that affect the ocular surface, such as systemic autoimmune diseases
Primary outcome measure(s)
Level of visual acuity — 1 month Participants will undergo visual acuity assessment including uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) using Snellen chart at every visit. The last line on the chart that subjects are able to read correctly will be selected to calculate the visual acuity.
Trial sites (1)
Facility
City
Region
Status
Singapore National Eye Centre
Singapore
Singapore
Recruiting
More Singapore Eye Research Institute trials in Singapore
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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