This cross-sectional study aims to investigate the associations between dietary intake, cardiometabolic health markers, and gut microbiota composition in Singapore adults.
Eligibility
Sex
ALL
Min age
21 Years
Max age
80 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. Able to give informed consent
2. Adults 21-80 years old
3. English-literate
4. Have venous access sufficient to allow for blood sampling as per the protocol
5. No drastic change of diet for the past 1 year
6. If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 5 years prior to starting the study.
Exclusion Criteria:
1. Taking dietary supplements and fermented foods, which may impact the gut microbiota (e.g. antibiotics, prebiotics, probiotics, yogurt, kimchi) 2 months before starting the 1st study visit only.
2. Taking dietary supplements or medications, which may impact sleep outcomes (e.g. Nutritional Shakes (e.g. Ensure), tryptophan, 5-hydroxytryptophan or melatonin supplementations) 1 month before starting the study.
3. Taking dietary supplements which may impact the eye outcomes (e.g. Vitamin A, vitamin A-containing multivitamin) 2 months before starting the study.
Primary outcome measure(s)
Dietary intake — Day 7 Use a 3-day food record to document dietary intake
Blood pressure — Day 1 Systolic and diastolic blood pressure (in mmHg) will be measured by a blood pressure monitor.
Blood lipid lipoprotein profile — Day 1 Total cholesterol, LDL, HDL, and triglyceride concentration in the blood will be measured
Fasting blood glucose — Day 1 Glucose concentration in the blood will be measured
Endothelial Progenitor Cell Count — Day 1 Endothelial functions are determined by the percentage of endothelial progenitor cells (CD34+/KDR+) expression in peripheral blood mononuclear cells
Fecal short chain fatty acid (SCFA) concentration — Day 1 SCFA concentration in the blood will be measured
Trimethylamine N-oxide (TMAO) — Day 1 Trimethylamine N-oxide (TMAO) concentration in the blood will be measured
Fecal bile acids — Day 1 Bile acids concentration will be determined from fecal samples of the subjects
Fecal zonulin — Day 1 Zonulin concentration will be determined from fecal samples of the subjects
Fecal calprotectin — Day 1 Calprotectin concentration will be determined from fecal samples of the subjects
Estimated Glomerular Filtration Rate (eGFR) — Day 1 The estimated Glomerular Filtration Rate (eGFR) of the subjects will be measured from the blood
Trial sites (1)
Facility
City
Region
Status
National University of Singapore
Singapore
Singapore
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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