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Clinical Trials in Singapore / NCT03531658
Active, not recruiting Observational

Singapore PREconception Study of Long-Term Maternal and Child Outcomes

NCT03531658 · tracked via the Priya Life Science Singapore tracker
Phase
Observational
Started
2015-02-27
Last updated
2026-05-26

Condition(s) studied

Metabolic DiseaseNeurological and Mental Health ConditionsGenetics PredispositionSkin ConditionEnvironmental ExposureSocioeconomic FactorsPsychology, Social

Study summary

We aim to test the following primary hypothesis that nutrition, lifestyle, and maternal emotional health prior to pregnancy and/or during the first trimester alter the expression of metabolic or neurodevelopmental endophenotypes with accompanying effects on the epigenome/transcriptome of the offspring.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria of Mother Participants: 1. Women aged 18-35 years 2. Intention to reside in Singapore for the next 5 years 3. Chinese, Malay, Indian or any combinations of these 3 ethnic groups 4. Planning to conceive within 1 year 5. Able to provide written, informed consent Exclusion Criteria of Mother Participants: 1. Have been actively trying to conceive for more than 18 months 2. Currently pregnant 3. Assisted fertility, apart from those taking clomiphene alone in the past 1 month 4. Established pre-existing diabetes (type 1 or type 2) 5. Oral or implanted contraception, or with an IUCD in situ in the past 1 month 6. On systemic steroids in the past 1 month 7. On anticonvulsants in the past 1 month 8. On HIV or Hepatitis B or C medication in the past 1 month 9. Not becoming pregnant after more than 12 months from recruitment 10. Eventual multiple pregnancies 11. Pregnancy complications such as miscarriages, ectopic pregnancy, still birth The partners of the women will also be invited to participate in the study. Babies born from these mothers will be followed up until the child is 9 years of age.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
KK Women's and Children's Hospital Singapore Singapore

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT03531658 on ClinicalTrials.gov ↗ ← All trials in Singapore