Metabolic DiseaseNeurological and Mental Health ConditionsGenetics PredispositionSkin ConditionEnvironmental ExposureSocioeconomic FactorsPsychology, Social
Study summary
We aim to test the following primary hypothesis that nutrition, lifestyle, and maternal emotional health prior to pregnancy and/or during the first trimester alter the expression of metabolic or neurodevelopmental endophenotypes with accompanying effects on the epigenome/transcriptome of the offspring.
Eligibility
Sex
ALL
Min age
—
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria of Mother Participants:
1. Women aged 18-35 years
2. Intention to reside in Singapore for the next 5 years
3. Chinese, Malay, Indian or any combinations of these 3 ethnic groups
4. Planning to conceive within 1 year
5. Able to provide written, informed consent
Exclusion Criteria of Mother Participants:
1. Have been actively trying to conceive for more than 18 months
2. Currently pregnant
3. Assisted fertility, apart from those taking clomiphene alone in the past 1 month
4. Established pre-existing diabetes (type 1 or type 2)
5. Oral or implanted contraception, or with an IUCD in situ in the past 1 month
6. On systemic steroids in the past 1 month
7. On anticonvulsants in the past 1 month
8. On HIV or Hepatitis B or C medication in the past 1 month
9. Not becoming pregnant after more than 12 months from recruitment
10. Eventual multiple pregnancies
11. Pregnancy complications such as miscarriages, ectopic pregnancy, still birth
The partners of the women will also be invited to participate in the study. Babies born from these mothers will be followed up until the child is 9 years of age.
Primary outcome measure(s)
Offspring adiposity — From birth until 10 years of age Offspring adiposity (total and percentage fat mass) measured by skinfold calipers, air-displacement plethysmography, quantitative magnetic resonance (QMR), Bioelectrical Impedance Analysis (BIA), and Magnetic resonance imaging (MRI).
Offspring neurocognitive and behavioural development — From 3-12 months up till 10 years of age Offspring neurocognitive and behavioural development measured by questionnaires, behavioural tasks and brain MRI.
Trial sites (1)
Facility
City
Region
Status
KK Women's and Children's Hospital
Singapore
Singapore
More KK Women's and Children's Hospital trials in Singapore
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.