Mapping Antenatal Maternal Stress

Condition(s) studied

Study summary

This study recruits women from early-mid pregnancy and later follows their children after birth, tracking both the mother and child until the child reaches at least 4 years of age. The study aims to examine the determinants of maternal mental health during pregnancy and how genetic factors could influence maternal mental health and child outcomes.

Eligibility

Primary outcome measure(s)

• Cumulative psychosocial risk index of maternal depression and anxiety — From pregnancy up to 2 years postnatal
  To create a cumulative risk index by collecting data using existing validated measures on known risk factors for maternal depression and anxiety, including 1) low socio-economic status, 2) poor marital relations, 3) low social support, 4) high levels of perceived stress, 5) high levels of neuroticism, 6) low self-esteem, 7) poor family function, and 8) childhood adversity in the form of maltreatment and/or poor parental relations.
• Polygenic risk score for differential susceptibility to environmental susceptibility — From pregnancy up to 2 years postnatal
  To identify genotypic variation associated with perinatal maternal mental health
• Determinants of maternal symptoms of depression and anxiety with those that predict positive maternal mental health — From pregnancy up to 2 years postnatal
  To compare the determinants of maternal symptoms of depression and anxiety with those that predict the level of positive mental health

Trial sites (1)

More Institute for Human Development and Potential (IHDP), Singapore trials in Singapore

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