🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Contributor sign in
Latest
Clinical Trials in Germany / NCT07668388
Recruiting Phase 2

A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes

NCT07668388 · tracked via the Priya Life Science Germany tracker
Phase
Phase 2
Started
2026-06-22
Last updated
2026-09-11

Condition(s) studied

Diabetes Mellitus, Type 2

Investigational drug(s) / intervention(s)

UBT251 →UBT251 PlaceboSemaglutide →Semaglutide Placebo

UBT251: UBT251 will be administered subcutaneously once-weekly.

UBT251 Placebo: UBT251 placebo will be administered subcutaneously once-weekly.

Semaglutide: Semaglutide will be administered subcutaneously once-weekly.

Semaglutide Placebo: Semaglutide placebo will be administered subcutaneously once-weekly.

Study summary

The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Participants will either get UBT251, UBT251 placebo, semaglutide, or semaglutide placebo. Which treatment participants get is decided by chance. UBT251 is the treatment being tested and is not yet available for doctors to prescribe, while semaglutide is a medicine used to treat type 2 diabetes that doctors can already prescribe.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18-75 years (both inclusive) at the time of signing the informed consent. * Diagnosed with type 2 diabetes greater than or equal to (≥) 180 days before screening. * Stable daily dose(s) ≥ 90 days before screening of the following antidiabetic drug(s) or combination regimen(s) at effective or maximum tolerated dose as judged by the investigator: metformin with or without sodium-glucose cotransporter-2 (SGLT2) inhibitor. * HbA1c of 7.0-10.5 percent (%) (53-91 millimoles per mole (mmol/mol)) (both inclusive) as assessed by central laboratory at screening. * Body mass index between 25.0 kg/m\^2 and 50.0 kg/m\^2 (both inclusive) at screening. Exclusion Criteria: * Treatment with any medication (prescription or over-the counter) or alternative remedies for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed. * Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by an eye examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination. * Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire, question 8.

Primary outcome measure(s)

Trial sites (70)

FacilityCityRegionStatus
Flourish Research Birmingham Alabama Recruiting
Ark Clinical Research Fountain Valley California Recruiting
Ark Clinical Research Long Beach California Recruiting
Los Angeles Institute for Metabolic Research Los Angeles California Recruiting
Catalina Research Institute, LLC Montclair California Recruiting
Encore Medical Research LLC Hollywood Florida Recruiting
South Broward Research LLC Miramar Florida Recruiting
Encore Medical Research of Weston Weston Florida Recruiting
Midwest Inst For Clin Res Indianapolis Indiana Not Yet Recruiting
Cotton O'Neil Diabetes & Endocrinology Topeka Kansas Recruiting
MD Medical Research Oxon Hill Maryland Recruiting
PharmQuest Greensboro North Carolina Not Yet Recruiting
KDCILM, LLC & Accellacare US, Inc. Wilmington North Carolina Recruiting
Plains Clinical Research Center, LLC_Fargo Fargo North Dakota Not Yet Recruiting
Preferred Primary Care Physicians, Inc. Uniontown Pennsylvania Recruiting
Monroe Biomedical Research, LLC North Charleston South Carolina Recruiting
LifeDoc Health Memphis Tennessee Recruiting
IMA Clinical Research Austin Texas Recruiting
Private Practice - Dr. Laila A. Hassan Houston Texas Recruiting
Radiance Clinical Research Lampasas Texas Recruiting
Quality Research Inc San Antonio Texas Recruiting
Tekton Research Inc San Antonio Texas Recruiting
Consano Clin Res-Shavano Park Shavano Park Texas Recruiting
Chrysalis Clinical Research St. George Utah Recruiting
The Vancouver Clinic Vancouver Washington Not Yet Recruiting
Castle Hill Medical Centre Castle Hill New South Wales Recruiting
Novatrials Charlestown New South Wales Not Yet Recruiting
Hunter Medical Research Institute - Endocrinology and Diabetes New Lambton Heights New South Wales Not Yet Recruiting
Roger Chih Yu Chen Sydney New South Wales Recruiting
Royal Adelaide Hospital - Cardiology Department Adelaide South Australia Recruiting
Baker Heart and Diabetes Institute Melbourne Victoria Recruiting
Versdias - Diabetologikum Amberg Amberg Bavaria Recruiting
Herz- und Diabeteszentrum NRW - Bad Oeynhausen Bad Oeynhausen Germany Recruiting
Medizinisches Versorgungszentrum Am Bahnhof Spandau GbR Berlin Germany Recruiting
DSP Bochum, Diabetes- und Stoffwechselpraxis Bochum Germany Not Yet Recruiting
Studiengesellschaft Dres. Könemann/Steinmann GbR Bünde Germany Not Yet Recruiting
InnoDiab Forschung GmbH Essen Germany Recruiting
Mesut Durmaz, Hof Hof Germany Recruiting
CRS Clinical Research Services Mannheim GmbH (hVIVO Mannheim) Mannheim Germany Recruiting
Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ Szeged Csongrád-Csanád Recruiting

+ 30 more sites — see the full list on the official registry below.

On this site

📄 Ozempic (semaglutide) drug profile →

More Novo Nordisk A/S trials in Germany

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07668388 on ClinicalTrials.gov ↗ ← All trials in Germany