Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension

NCT07538388 · tracked via the Priya Life Science Germany tracker

Sponsor

Universitätsklinikum Hamburg-Eppendorf

Phase

Not applicable

Started

2026-05-07

Last updated

2026-06-29

Condition(s) studied

Postinduction Hypotension

Investigational drug(s) / intervention(s)

Continuous Norepinephrine Administration

Continuous Norepinephrine Administration: In patients assigned to continuous administration of norepinephrine, a syringe infusion pump will be prepared and connected to a peripheral or central venous catheter. The responsible anesthesiologist will start the norepinephrine infusion and adjust the infusion rate as necessary and may administer additional norepinephrine boluses via the syringe infusion pump if required.

Study summary

INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.

Eligibility

Sex

ALL

Min age

45 Years

Max age

—

Healthy volunteers

Inclusion Criteria: We will include consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia with planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter and with at least two of the following risk criteria for developing acute kidney injury: * Age ≥65 years * ASA physical status III or IV * Chronic arterial hypertension * Diabetes mellitus requiring medication * Intra-abdominal surgery * Preoperative renal insufficiency (serum creatinine ≥1.2 mg/dL) Exclusion Criteria: * Pregnancy * Cardiac arrhythmia * History of intracranial hemorrhage or intracranial aneurysm * Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure) * Patients who are unable to understand, read, and provide informed consent in German

Primary outcome measure(s)

Area under a mean arterial pressure (MAP) of 65 mmHg (mmHg x min) — First 15 minutes after starting induction of general anesthesia. The start of anesthetic induction is defined as the administration of propofol as hypnotic induction agent.

Trial sites (4)

Facility	City	Region	Status
Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin	Berlin	Germany	Not Yet Recruiting
Department of Anesthesiology, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf	Düsseldorf	Germany	Recruiting
Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf	Hamburg	Germany	Recruiting
Department of Anaesthesiology, University Hospital LMU Munich	München	Germany	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07538388 on ClinicalTrials.gov ↗ ← All trials in Germany