Exercise Therapy for Multiple Myeloma Patients

NCT07388147 · tracked via the Priya Life Science Germany tracker

Sponsor

University Hospital Heidelberg

Phase

Not applicable

Started

2026-03-01

Last updated

2026-02-04

Condition(s) studied

Multiple Myeloma Bone Lesions

Investigational drug(s) / intervention(s)

Orthopedic consultation and rehabilitation by excercise therapy

Orthopedic consultation and rehabilitation by excercise therapy: All patients will receive a continuous orthopaedic consultation on bone stability and recommendations for exercise therapy during the different phases of systemic myeloma therapy. Thereby, structural measures to improve rehabilitation in multiple myeloma will be established and evaluated with the intention of integrating them into routine clinical care.

Study summary

Physical exercise is an important supportive therapy for cancer patients, as it improves quality of life in general and might mitigate the side effects of drug treatment. For patients with multiple myeloma in particular, significantly less evidence on the effectiveness of exercise therapy is available due to the fact that this disease is associated with severe bone degradation which might affect bone stability. Advances in oncologic drug treatment have improved overall survival in multiple myeloma significantly. Therefore, there is an increased interest for recommendations on physical activity in this patient group. Due to uncertainties regarding safety and feasibility of exercise therapy in multiple myeloma, both patients and therapists often remain hesitant. Therefore, an orthopaedic outpatient clinic has been established at the Myeloma Center of Heidelberg University Hospital. Here, patients receive consultation on bone stability and individualized physical exercise plans. Based on the expertise gained at the orthopaedic outpatient clinic, the aim of this study is to establish and evaluate structural measures for improved rehabilitation in multiple myeloma and to integrate them into routine clinical care.

Eligibility

Sex

ALL

Min age

18 Years

Max age

75 Years

Healthy volunteers

Inclusion Criteria: * newly diagnosed multiple myeloma * Survival prognosis \> 6 months * ECOG status ≤ 3 * Age ≥18 years * Patients who state that they want to carry out the training program at least 2 x/week and participate in the planned follow-up visits * Ability to give informed consent * Written consent to participate in the study * Sufficient knowledge of written and spoken German Exclusion Criteria: * physical or mental limitation that would prevent participation in the training program or the planned follow-up visits

Primary outcome measure(s)

Change in physical function — From enrollment to the end of induction therapy after 18 weeks
Results of the EORTC QLQ-C30 questionnaire ("Physical functioning" scale)

Trial sites (1)

Facility	City	Region	Status
Heidelberg University Hospital - GMMG Study Group	Heidelberg	Germany

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07388147 on ClinicalTrials.gov ↗ ← All trials in Germany