Feasibility, Safety and Effectivity of an Exercise Intervention for Newly Diagnosed Multiple Myeloma Patients During Induction Therapy

NCT07026799 · tracked via the Priya Life Science Germany tracker

Sponsor

University Hospital Heidelberg

Phase

Not applicable

Started

2023-04-14

Last updated

2025-06-18

Condition(s) studied

Multiple Myeloma Bone Lesions

Investigational drug(s) / intervention(s)

ExerciseControl group

Exercise: Orthopedic consultation and home-based, individualized, structured resistance training during induction therapy.

Control group: Orthopedic consultation and stretching exercises/walking. No resistance training.

Study summary

Physical exercise is an important supportive therapy for cancer patients, which improves quality of life and can effectively counteract the side effects of drug therapy. There is very little experience whether physical activity can also be performed safely by patients with malignant diseases that affect bone stability. This applies in particular to patients with multiple myeloma, a disease characterized by a monoclonal proliferation of plasma cells in the bone marrow and often accompanied by severe bony destruction. Aim of this exploratory randomized controlled trial is to evaluate feasibility, safety and effectivity of an orthopaedic-guided exercise intervention during induction therapy in newly diagnosed multiple myeloma patients.

Eligibility

Sex

ALL

Min age

18 Years

Max age

70 Years

Healthy volunteers

Inclusion Criteria: * newly diagnosed multiple myeloma * Survival prognosis \> 6 months * ECOG status ≤ 3 * Age ≥18 years * Patients who state that they want to carry out the training program at least 2 x/week and participate in the planned follow-up visits * Ability to give informed consent * Written consent to participate in the study * Sufficient knowledge of written and spoken German Exclusion Criteria: * physical or mental limitation that would prevent participation in the training program or the planned follow-up visits. * Carrying out a regular, intensive training program (min. 1h, 2x/week)

Primary outcome measure(s)

Fatigue (MFI, Multidimensional Fatigue Inventory) — From enrollment to the end of stem cell transplantation (approximately one year)

Trial sites (1)

Facility	City	Region	Status
Heidelberg University Hospital - GMMG Study Group	Heidelberg	Germany

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07026799 on ClinicalTrials.gov ↗ ← All trials in Germany