Heart TransplantationDilated Cardiomyopathy (DCM)Hypertrophic Cardiomyopathy (HCM)Myocarditis, PericarditisAmyloidosis CardiacCardiomyopathiesSarcoidosis of the Heart
Study summary
The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial diseases and thereby contribute to improving diagnosis and therapy.
The main aim is:
-Identification of molecular profiles (e.g., proteome, lipidome, metabolome) and immune signalling profiles that are specifically associated with different myocardial diseases and the post-heart transplantation course.
Participants already receiving an endomyocardial biopsy as part of their regular medical care will be enrolled. An additional biopsy sample will be taken for the above mentioned research.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients aged \>18 years with a clinical indication for endomyocardial biopsy.
* Patients capable of providing informed consent who have signed the consent form for participation in the study.
Exclusion Criteria:
* Patients without a clinical indication for endomyocardial biopsy (EMB).
* Pregnant individuals.
* Patients incapable of providing informed consent.
* Women of childbearing potential who are not using adequate contraception.
Primary outcome measure(s)
Spatial molecular profiles and immune signalling in all included patients — Baseline, up to 1 year Identification of spatial molecular profiles (e.g., proteomic, lipidomic, and metabolomic signatures) and immune signalling pathways specifically associated with various myocardial diseases and post-heart transplantation outcomes.
Trial sites (1)
Facility
City
Region
Status
Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University Hospital Essen, Germany
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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