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Clinical Trials in Germany / NCT07036523
Active, not recruiting Phase 2

A Study to Find Out Whether BI 765423 Has an Effect on Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF) With or Without Standard Treatment

NCT07036523 · tracked via the Priya Life Science Germany tracker
Phase
Phase 2
Started
2025-11-13
Last updated
2026-09-25

Condition(s) studied

Idiopathic Pulmonary Fibrosis

Investigational drug(s) / intervention(s)

BI 765423Placebo

BI 765423: BI 765423

Placebo: Placebo to BI 765423

Study summary

This study is open to adults who are at least 40 years old and have idiopathic pulmonary fibrosis (IPF). People can participate in the study if they have a forced vital capacity (FVC) greater than or equal to 45% of the predicted value and fibrosis of 20% or more confirmed by a high-resolution computed tomography (HRCT) scan. The purpose of this study is to find out if a medicine called BI 765423 can improve lung function in people with IPF. The study will compare BI 765423 with a placebo to see if there is a difference in lung capacity after 3-6 months of treatment and will also look at changes in certain markers related to lung health.

Participants are put into two groups randomly, which means by chance. One group receives the study medicine, and the other group receives a placebo. Placebo looks like BI 765423 but does not contain any study medicine. The study medicine is given as an infusion into a vein every four weeks.

Participants are in the study for up to 11 months. During the study, participants may continue their regular treatment for IPF. During the study they visit the study site several times for screening, treatment, and follow-up. Doctors regularly test lung function by measuring FVC and take blood samples to measure study endpoints. The results are compared between the two groups to see whether the treatment works. The doctors also check participants' health and take note of any unwanted effects.

Eligibility

Sex
ALL
Min age
40 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria : 1. 40 years of age or older at the time of informed consent signature. 2. Signed and dated written informed consent in accordance with International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use - Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial. 3. Male or female patients. Male patients must not donate sperm while taking part in this study and for a specific period after the last dose of the IMP. Male patients with woman of childbearing potential (WOCBP) sexual partners must use contraception (male condom) to avoid exposure via seminal fluid during treatment and for a specific period after last drug intake. Women can only be included if they are of non-childbearing potential, defined as meeting at least one of the below conditions: * Permanently surgically sterilised (hysterectomy, bilateral salpingectomy and/or bilateral oophorectomy) * Postmenopausal, defined as no menses for 12 months without an alternative medical cause. In questionable cases wherein the menopausal status is uncertain and cannot be clearly determined, the following should be taken into consideration by the investigator: * Women not using sex hormone medication such as hormone replacement therapy may be included if a blood sample confirms levels of follicle stimulating hormone (FSH) \> 40 U/L and estradiol \< 30 ng/L" 4. Patients with a documented diagnosis of IPF prior to Visit 1, confirmed by the investigator as per the 2022 American Thoracic Society (ATS)/European Respiratory Society (ERS)/Japanese Respiratory Society (JRS)/Latin American Thoracic Association (ALAT) Guideline and, if available, surgical lung biopsy or transbronchial lung cryobiopsy histopathology report. 5. Patients with a high-resolution computed tomography (HRCT) taken within 12 months of Visit 1 (or during the screening period, if not available) confirming "UIP" or "probable UIP" HRCT pattern consistent with the clinical diagnosis of IPF by central review (prior to Visit 2). * Patients with an "indeterminate" HRCT finding are eligible if a clinical diagnosis of IPF can be confirmed based on an historical histopathology report of a surgical lung biopsy or cryobiopsy demonstrating a "UIP" or "Probable UIP" pattern or Multidisciplinary Discussion and Diagnosis as per ATS guidelines. * Patients with an "alternative diagnosis" HRCT finding are eligible if a clinical diagnosis of IPF can be confirmed based on an historical histopathology report of a surgical lung biopsy or cryobiopsy demonstrating a "UIP" pattern Multidisciplinary Discussion and Diagnosis as per ATS guidelines. 6. Patients with an extent of fibrosis ≥20% as per an HRCT of the chest performed within 12 months prior to Visit 1 or during the screening period (if not available) and confirmed by central review. 7. Patients with a Forced vital capacity (FVC) ≥45% predicted at Visit 1. Predicted normal values will be calculated according to Global Lung Initiative (GLI). 8. Patients with haemoglobin-corrected diffusing capacity of the lungs for carbon monoxide (DLCO) ≥20% predicted at Visit 1. Further inclusion criteria apply. Exclusion criteria: 1. Acute exacerbation of IPF within at least 12 weeks prior to Visit 1 and/or during the screening period (investigator-determined). 2. Relevant airways obstruction (pre-bronchodilator forced expiratory volume in 1 second (FEV1)/FVC \<0.7) at Visit 1. 3. Lower respiratory tract infection requiring treatment within 4 weeks prior to Visit 1 and/or during the screening period. 4. Significant PH defined by any of the following: * Previous clinical or echocardiographic evidence of significant right heart failure according to investigator's judgement * History of right heart catheterisation showing a cardiac index ≤2 L/min/m\^² * PH requiring parenteral therapy with prostanoids 5. On nintedanib or pirfenidone treatment for less than 12 weeks prior Visit 1, planning to start nintedanib or pirfenidone within the first 12 weeks of investigational medicinal product (IMP) treatment or on combined nintedanib plus pirfenidone treatment. Newly diagnosed patients considered in need of SoC treatment during the next 12 weeks by the treating physician, who would be withheld SoC treatment only for the sake of participation in the trial, should also be excluded. 6. Cardiovascular comorbidities including * Severe hypertension (uncontrolled under treatment≥160/100 mmHg at multiple occasions) within 3 months of Visit 1 * Myocardial infarction, stroke, or transient ischemic attack within 6 months of Visit 1 * Unstable cardiac angina within 6 months of Visit 1 7. Life expectancy for any concomitant disease other than IPF \<2.5 years (investigator assessment). Further exclusion criteria apply.

Primary outcome measure(s)

Trial sites (46)

FacilityCityRegionStatus
University of Alabama at Birmingham Birmingham Alabama
University of Florida Gainesville Florida
Renstar Medical Research Ocala Florida
University of Iowa Hospitals and Clinics Iowa City Iowa
University of Kansas Medical Center Kansas City Kansas
University of Minnesota Minneapolis Minnesota
The Lung Research Center, LLC Chesterfield Missouri
University of Missouri Health System Columbia Missouri
Columbia University Medical Center-New York Presbyterian Hospital New York New York
Weill Cornell Medical College New York New York
Duke University Medical Center Durham North Carolina
University of Cincinnati Medical Center Cincinnati Ohio
Temple University Philadelphia Pennsylvania
Clinical Trials Center of Middle Tennessee, LLC Franklin Tennessee
University of Virginia Health System Charlottesville Virginia
The Prince Charles Hospital Chermside Queensland
Monash Health Clayton Victoria
Institute for Respiratory Health Nedlands Western Australia
Cliniques Universitaires Saint-Luc Brussels Belgium
Yvoir - UNIV UCL de Mont-Godinne Yvoir Belgium
Synergy Respiratory Care Sherwood Park Alberta
Kelowna Respirology & Allergy Research Kelowna British Columbia
QEII Health Sciences Centre Halifax Nova Scotia
Centre Hospitalier de l'Universite de Montreal (CHUM) Montreal Quebec
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH Essen Germany
Medizinische Hochschule Hannover Hanover Germany
ASST Papa Giovanni XXIII Bergamo Italy
A. O. Universitaria Careggi Florence Italy
Azienda Ospedaliera dei Colli Naples Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS Roma Italy
Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino Torino Italy
Tosei General Hospital Aichi, Seto Japan
University of Fukui Hospital Fukui, Yoshida-gun Japan
National Hospital Organization Kyushu Medical Center Fukuoka, Fukuoka Japan
Kanagawa Cardiovascular and Respiratory Center Kanagawa, Yokohama Japan
National Hospital Organization Kinki-Chuo Chest Medical Center Osaka, Sakai Japan
Hamamatsu University Hospital Shizuoka, Hamamatsu Japan
Soon Chun Hyang University Hospital Bucheon Bucheon-si, Gyeonggi-do South Korea
Inje University Haeundae Paik Hospital Busan South Korea
Soonchunhyang University Hospital Seoul Seoul South Korea

+ 6 more sites — see the full list on the official registry below.

More Boehringer Ingelheim trials in Germany

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07036523 on ClinicalTrials.gov ↗ ← All trials in Germany