Urethral PeRfusion Index-Guided Hemodynamic ManagemenT in Patients Having Major Abdominal Surgery: the UPRIGHT Randomized Feasibility Trial

NCT06799832 · tracked via the Priya Life Science Germany tracker

Sponsor

Universitätsklinikum Hamburg-Eppendorf

Phase

Not applicable

Started

2025-01-21

Last updated

2025-02-21

Condition(s) studied

Urethral Perfusion IndexTissue PerfusionMicrocirculation

Investigational drug(s) / intervention(s)

urethal perfusion index monitoring

urethal perfusion index monitoring: The urethral perfusion index will be monitored using the IKORUS System (Vygon, Écouen, France)

Study summary

We will perform this single-center pilot trial to determine if the intraoperative urethral perfusion index is higher in patients assigned to maintaining postinduction baseline urethral perfusion index than in patients assigned to routine care (with blinded urethral perfusion index monitoring). As pre-planned substudies, we will also assess the agreement between a) urethral perfusion index-derived pulse rate and heart rate measured with an electrocardiogram and b) between the urethral perfusion index and the peripheral perfusion index.

Eligibility

Sex

ALL

Min age

45 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * at least 45 years old * scheduled for elective major abdominal surgery (involving visceral organs with an expected duration of at least 120 minutes) * indication for an arterial catheter * indication for an urinary catheter Exclusion Criteria: * Pregnancy * Planned surgery: nephrectomy, liver or kidney transplantation surgery * Patients who previously had surgery on the urethra or bladder * Patients without clinical indication for continuous blood pressure monitoring with an intraarterial catheter

Primary outcome measure(s)

average intraoperative urethral perfusion index — Start of surgery until end of surgery

Trial sites (2)

Facility	City	Region	Status
University Medical Center Hamburg-Eppendorf	Hamburg	Germany	Not Yet Recruiting
University Medical Center Hamburg-Eppendorf	Hamburg	Germany	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06799832 on ClinicalTrials.gov ↗ ← All trials in Germany